OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives

Abstract

The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD.

Special Issue: “Neurodegenerative Diseases: Recent Advances and Future Perspectives”

“…In this Special Issue, we have compiled innovative research covering various aspects related to neurodegenerative diseases: advances in monitoring the progression of Huntington's disease and multiple sclerosis [4], therapies aimed at improving executive function in mild cognitive impairment (MCI), as well as ocular imaging techniques for diagnosis and monitoring, and risk factor analysis [5]. Literature reviews have also been included to update the materials used in peripheral nervous system therapies, neuroprotective compounds, as well as the most advanced techniques in animal model research [6].…”