OCT Imaging for the Management of Pulmonary Hypertension

Dai, Zhehao; Fukumoto, Yoshihiro; Tatebe, Shunsuke; Sugimura, Koichiro; Miura, Yutaka; Nochioka, Kotaro; Aoki, Tatsuo; Miyamichi-Yamamoto, Saori; Yaoita, Nobuhiro; Satoh, Kimio; Shimokawa, Hiroaki

doi:10.1016/j.jcmg.2014.01.020

Cited by 28 publications

(24 citation statements)

References 2 publications

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“…1- 3 We have recently shown that OCT is useful in the management of pulmonary hypertension, not only for diagnosis but also for evaluation of treatment. 4 Here, we show that OCT is also useful to document regression of pulmonary arterial remodeling in response to medical treatment.…”

Section: Images In Cardiovascular Medicine Dai Z Et Almentioning

confidence: 74%

“…4 These 3 structural parameters of the pulmonary arteries were progressively improved along with improvement of pulmonary hemodynamics during medical treatment (Figure 2). The lesion detected on OCT was similar to OCT findings of intimal fibrosis confirmed on histopathology in PAH in a previous report, 9 but there is not sufficient evidence to completely deny other types of lesion in the present case, and further studies regarding comparison between OCT findings and histopathology are required.…”

mentioning

confidence: 96%

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Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension

Dai

Sugimura

Tatebe

et al. 2014

Circ J

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Section: Images In Cardiovascular Medicine Dai Z Et Almentioning

confidence: 74%

mentioning

confidence: 96%

Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension

Dai

Sugimura

Tatebe

et al. 2014

Circ J

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“…1). Two articles included OCT follow-up data [18,19]. The independent quality assessments were in agreement in all 14 cases (3 moderate and 11 weak).…”

Section: Study Selectionmentioning

confidence: 90%

“…Four studies from three different groups of investigators reported the methodology used to perform measurements of the pulmonary arterial wall thickness [18,19,21,24].…”

Section: Oct Image Interpretation and Measurementsmentioning

confidence: 99%

Optical coherence tomography of the pulmonary arteries: A systematic review

Jorge

Baptista

Calisto

et al. 2016

Journal of Cardiology

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Optical coherence tomography (OCT) is an imaging technique extensively used for visualizing the coronary circulation, where it assists clinical decision-making. Along with the new interventional procedures being introduced for pulmonary vascular disease, there is an increasing need for intravascular imaging of the pulmonary arteries. Additionally, measurements of the wall thickness of the pulmonary arteries of patients with various types of pulmonary hypertension (PH) may provide relevant diagnostic and prognostic information. The aim of this review is to summarize all the available evidence on the use of OCT for imaging the pulmonary bed and to describe a simple protocol for OCT image acquisition. We conducted a systematic review of the literature using electronic reference databases through February 2015 (MEDLINE, Cochrane Library, Web of Knowledge, and references cited in other studies) and the search terms "optical coherence tomography," "pulmonary hypertension," and "pulmonary arteries." Studies in which OCT was used to image the pulmonary vessels were considered for inclusion. We identified 14 studies reporting OCT imaging data from the pulmonary arteries. OCT was able to identify intravascular thrombi in patients with chronic thromboembolic PH (CTEPH), and an increase in vessel wall thickness was found in most patients with PH, compared with the controls. OCT has also been reported to be useful for the selection of balloon size in the setting of balloon pulmonary angioplasty for CTEPH. The main limitations include lack of standardization, little data on outcomes, cost, and the technical limitations involved in visualizing small-diameter (<1mm) pulmonary vessels. OCT has become a potential tool for the in vivo study of vascular changes in the pulmonary arteries, and may provide additional information in the assessment of patients with PH. Prospective high-quality studies assessing the safety, validity, and clinical impact of OCT imaging for pulmonary vessels are warranted.

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“…30 In addition to CyPA and Bsg, several novel pathogenic proteins that are potentially useful biomarkers for PAH have been found. 59-61 imaging techniques to evaluate pulmonary arterial remodeling in patients with PAH have been developed, 62, 63 and, in addition, it has been found that pravastatin and metformin ameliorate hypoxia-induced PH in mice. 25, 46 Recently, microarray analyses using PAHPASMCs to identify further common pathogenic proteins showed significant changes in 1,858 genes in PAH-PASMCs compared with control PASMCs.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research

Satoh

2017

Circ J

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Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells, inflammatory cells, activated platelets, and cardiac fibroblasts in response to oxidative stress. Excessive and continuous activation of the RhoA/Rho-kinase system promotes the secretion of CyPA, resulting in the development of multiple cardiovascular diseases. Basigin (Bsg), a transmembrane glycoprotein that activates matrix metalloproteinases, is an extracellular receptor for CyPA that promotes cell proliferation and inflammation. Thus, the CyPA/Bsg system is potentially a novel therapeutic target for cardiovascular diseases. Importantly, plasma CyPA levels are increased in patients with coronary artery disease, abdominal aortic aneurysms, pulmonary hypertension, and heart failure. Moreover, plasma CyPA levels can predict all-cause death in patients with coronary artery disease and pulmonary hypertension. Additionally, plasma soluble Bsg levels are increased and predict all-cause death in patients with heart failure, suggesting that CyPA and Bsg are novel biomarkers for cardiovascular diseases. To discover further novel molecules targeting the CyPA/Bsg system, high-throughput screening of compounds found molecules that ameliorate the development of cardiovascular diseases. In addition to CyPA and Bsg, novel therapeutic targets and their inhibitors for patients with pulmonary arterial hypertension have been recently screened and identified. Ultimately, the final goal is to develop novel biomarkers and medications that will be useful for improving the prognosis and quality of life in patients with cardiovascular diseases.

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OCT Imaging for the Management of Pulmonary Hypertension

Cited by 28 publications

References 2 publications

Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension

Visualization of Complete Regression of Pulmonary Arterial Remodeling on Optical Coherence Tomography in a Patient With Pulmonary Arterial Hypertension

Optical coherence tomography of the pulmonary arteries: A systematic review

Development of Novel Therapies for Cardiovascular Diseases by Clinical Application of Basic Research

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