OCT guidance during stent implantation in primary PCI: A randomized multicenter study with nine months of optical coherence tomography follow-up

Kala, Petr; Červinka, Pavel; Jakl, Martin; Kaňovský, Jan; Kupec, Andrej; Špaček, Radim; Kvašňák, Martin; Poloczek, Martin; Červinková, Michaela; Bezerra, Hiram G.; Valenta, Zdeněk; Attizzani, Guilherme F.; Schnell, Audrey H.; Lu, Hong; Costa, Marco A.

doi:10.1016/j.ijcard.2017.10.059

Cited by 43 publications

(34 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were 5 [10,14,16–18] studies reference to random sequence generation used web-based system or random table, while 1 study [11] was just reported as randomized trials and without randomization description; 5 studies [12,13,15,19,20] of random grouping method were assessed as a high risk of bias. 4 trials [10,11,14,17] described allocate patients by sealed opaque envelopes. Because the nature of interventions, it was not possible to blind the operator, investigator, or patient for the allocated implantation technique in all trails, but the operator was blinded to the postprocedure OCT images in 1 trail.…”

Section: Resultsmentioning

confidence: 99%

“…[12,13] None of the included studies had a selective report nor incomplete report. In all, 3 studies [10,11,14] were with high methodological quality, 3 studies with moderate quality [16–18] and the rest 5 studies with low quality. [12,13,15,19,20] Figure 2 and Figure 3 presented a summary of the quality assessment process.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies [10,13,14,17,19] reported all-cause death, cardiovascular death, included a total of 1949 patients (988 in OCT-guided PCI group and 961 in angiography-guided PCI group). Six studies [11,15,16,18–20] reported cardiovascular death, included a total of 2604 patients (1176 in OCT-guided PCI group and 1428 in angiography-guided PCI group).…”

Section: Outcomes and Synthesis Of Resultsmentioning

confidence: 99%

“…By omitting 1 study at a time, the sensitivity analysis was conducted (Table 2). With regarding to MACE, the pooled results altered obviously when omitting the study of Ali et al [10] or Kala et al [14] Notably, significantly improved result was found after omitting these 2 studies. On the other hand, for stent thrombosis, the pooled result altered remarkably in the absence of the study of Sheth et al, [20] significantly improved result was found after omitting this study.…”

Section: Outcomes and Synthesis Of Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of clinical outcomes between intravascular optical coherence tomography-guided and angiography-guided stent implantation

Gong

et al. 2019

Medicine

View full text Add to dashboard Cite

Objective: This systematic review was designed to evaluate the overall efficacy of optical coherence tomography (OCT)-guided implantation versus angiography-guided for percutaneous coronary intervention. Methods: The following electronic databases, such as CENTRAL, PubMed, Cochrane, and EMBASE were searched for systematic reviews to investigate OCT-guided and angiography-guided implantation. We measured the following 7 parameters in each patient: stent thrombosis, cardiovascular death, myocardial infarction, major adverse cardiac events (MACE), target lesion revascularization (TLR), target vessel revascularization (TVR), all-cause death. Results: In all, 11 studies (6 RCTs and 5 observational studies) involving 4026 subjects were included, with 1903 receiving intravascular ultrasound-guided drug-eluting stent (DES) implantation and 2123 using angiography-guided DES implantation. With regard to MACE, MT, TLR, TVR, stent thrombosis and all-cause death, the group of OCT-guided implantation had no significant statistical association with remarkably improved clinical outcomes. However, its effect on cardiovascular death has a significant statistical difference in angiography-guided implantation group. Conclusion: In the present pool analysis, OCT-guided DES implantation showed a tendency toward improved clinical outcomes compared to angiography-guided implantation. More eligible randomized clinical trials are warranted to verify the findings and to determine the beneficial effect of OCT-guidance for patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Outcomes and Synthesis Of Resultsmentioning

confidence: 99%

Section: Outcomes and Synthesis Of Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of clinical outcomes between intravascular optical coherence tomography-guided and angiography-guided stent implantation

Gong

et al. 2019

Medicine

View full text Add to dashboard Cite

show abstract

“…This difference of enrolled patients might induce the proportion of uncovered struts between our study and other two studies. In one OCT study, a number of uncovered struts was observed in 12.8% of OCT-guided and 16.8% of image-guided primary PCI patients with STEMI at 9 months [24].…”

Section: Discussionmentioning

confidence: 99%

Impact of Combination Therapy with Ezetimibe/Simvastatin Treatment on the Neointimal Response to Biodegradable Polymer Biolimus-Eluting Stent Implantation in Patients with Acute Myocardial Infarction: Serial Assessment with Optical Coherence Tomography

et al. 2018

View full text Add to dashboard Cite

The aim of this study was to compare the neointimal response at 12-month follow-up between ezetimibe/simvastatin (Vytorin, manufactured by Merck) 10/10 mg and Vytorin 10/40 mg after biodegradable polymer Biolimus-eluting stent (BP-BES) implantation in patients with acute myocardial infarction (AMI). A total of 20 patients requiring revascularization were randomly assigned to receive either Vytorin 10/10 mg (n = 9) or Vytorin 10/40 mg (n = 11). Baseline optical coherence tomography (OCT) was performed after stent implantation, and follow-up OCT was scheduled at 12 months. We performed follow-up OCT in 18 patients (Vytorin 10/10 mg (n = 9) or Vytorin 10/40 mg (n = 9)). A total of 842 frames and 8552 struts were analyzed at initial and follow-up OCT. At follow-up, the percentage of uncovered struts was not significantly different between both groups (6.61 ± 10.29% vs. 7.57 ± 6.45%, p = 0.815). The percentage of malapposed struts was also similar between both groups (0.69 ± 1.58% vs. 1.55 ± 2.72%, respectively, p = 0.422). Mean percent neointimal hyperplasia area was not significantly different between both groups (6.53 ± 3.26% vs. 6.37 ± 8.96%, p = 0.961). This OCT study showed that both high- and moderate-intensity dosing of Vytorin was associated with relatively lower percentages of uncovered struts and malapposed struts after Biolimus A9-eluting stent implantation in patients with AMI.

show abstract

Optical coherence tomography versus angiography and intravascular ultrasound to guide coronary stent implantation: A systematic review and meta‐analysis

Siddiqi

Khan

Galougahi

et al. 2022

Cathet Cardio Intervent

View full text Add to dashboard Cite

Background: Optical coherence tomography (OCT) is an adjunct to angiographyguided coronary stent placement. However, in the absence of dedicated, appropriately powered randomized controlled trials, the impact of OCT on clinical outcomes is unclear.Objective: To conduct a systematic review and meta-analysis of all available studies comparing OCT-guided versus angiography-guided and intravascular ultrasound (IVUS)-guided coronary stent implantation.Methods: MEDLINE and Cochrane Central were queried from their inception through July 2022 for all studies that sought to compare OCT-guided percutaneous coronary intervention (PCI) to angiography-guided and IVUS-guided PCI. The primary endpoint was minimal stent area (MSA) compared between modalities.Clinical endpoints of interest were all-cause and cardiovascular mortality, major adverse cardiovascular events (MACE), myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), and stent thrombosis (ST). Risk ratios (RRs) and mean differences (MDs) with their corresponding 95% confidence intervals (CIs) were pooled using a random-effects model.Results: Thirteen studies (8 randomized control trials and 5 observational studies) enrolling 6312 participants were included. OCT was associated with a strong trend toward increased MSA compared to angiography (MD = 0.36, p = 0.06). OCT-guided PCI was also associated with a reduction in the incidence of all-cause mortality [RR = 0.59, 95% CI (0.35, 0.97), p = 0.04] and cardiovascular mortality [RR = 0.41, 95% CI (0.21, 0.80), p = 0.009] compared with angiography-guided PCI. Point estimates favored OCT relative to angiography in MACE [RR = 0.75, 95% CI (0.47, 1.20), p = 0.22] and MI [RR = 0.75, 95% CI (0.53, 1.07), p = 0.12]. No differences were detected in ST [RR = 0.71, 95% CI (0.21, 2.44), p = 0.58], TLR [RR = 0.71, 95% CI (0.17, 3.05), p = 0.65], or TVR rates [RR = 0.89, 95% CI (0.46, 1.73), p = 0.73].

show abstract

OCT guidance during stent implantation in primary PCI: A randomized multicenter study with nine months of optical coherence tomography follow-up

Cited by 43 publications

References 23 publications

Comparison of clinical outcomes between intravascular optical coherence tomography-guided and angiography-guided stent implantation

Comparison of clinical outcomes between intravascular optical coherence tomography-guided and angiography-guided stent implantation

Impact of Combination Therapy with Ezetimibe/Simvastatin Treatment on the Neointimal Response to Biodegradable Polymer Biolimus-Eluting Stent Implantation in Patients with Acute Myocardial Infarction: Serial Assessment with Optical Coherence Tomography

Optical coherence tomography versus angiography and intravascular ultrasound to guide coronary stent implantation: A systematic review and meta‐analysis

Contact Info

Product

Resources

About