OCT-based arterial elastography: robust estimation exploiting tissue biomechanics

Chan, Raymond C. K.; Chau, Alexandra H.; Karl, W.C.; Nadkarni, Seemantini K.; Khalil, Ahmad S.; Iftimia, Nicusor; Shishkov, Milen; Tearney, Guillermo J.; Kaazempur-Mofrad, Mohammad R.; Bouma, Brett E.

doi:10.1364/opex.12.004558

Cited by 93 publications

(84 citation statements)

References 16 publications

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“…3). OCT contrast enhancement (prerequisite 3) has been accomplished by introducing polarization-sensitive OCT, [24][25][26][27][28] phasesensitive OCT, [29][30][31][32][33] optical coherence elastography, [34][35][36][37][38][39] spectroscopic low coherence interferometry, [40][41][42][43] elastic scattering spectroscopy, 31,[44][45][46] and nonlinear interferometric vibrational imaging (NIVI), as well as employing endogenous or exogenous contrast. [47][48][49][50][51][52] In this paper, a recently developed contrast improvement for OCT, named label-free optical angiography, is reviewed (cf.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

View full text Add to dashboard Cite

show abstract

“…The term optical coherence elastography was first coined in a 2004 paper with Brett Bouma as last author [10] motivated by the then-emerging area of assessment of atherosclerotic plaque, which is now a major application of OCT [11]. Earlier that year, Rogowska et al [12] had reported, in essence, a repeat of the Schmitt experiments, but now on in vitro aorta samples, successively loaded with weights, instead of using an actuator.…”

Section: Optical Coherence Elastography Prehistorymentioning

confidence: 99%

“…2(b), did not show any recognizable structures, however, which did not suggest much promise. Later that year, Bouma and colleagues also began to explore the mechanical characterization of atherosclerotic plaque in vivo [10], an optical version of the then-emerging elastography based on intravascular ultrasound (IVUS) [13]. (We note in passing that the subsequent take-up of IVUS elastography has been slow [14]).…”

Section: Optical Coherence Elastography Prehistorymentioning

confidence: 99%

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Larin

Sampson

2017

Biomed. Opt. Express

356

258

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Abstract:Optical coherence elastography (OCE), as the use of OCT to perform elastography has come to be known, began in 1998, around ten years after the rest of the field of elastography -the use of imaging to deduce mechanical properties of tissues. After a slow start, the maturation of OCT technology in the early to mid 2000s has underpinned a recent acceleration in the field. With more than 20 papers published in 2015, and more than 25 in 2016, OCE is growing fast, but still small compared to the companion fields of cell mechanics research methods, and medical elastography. In this review, we describe the early developments in OCE, and the factors that led to the current acceleration. Much of our attention is on the key recent advances, with a strong emphasis on future prospects, which are exceptionally bright.

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“…There are several approaches commonly referred to as OCT elastography or optical coherence elastography (OCE). The early work is based on tracking the local displacement in the speckle pattern when constant stress is applied [100][101][102], which reveals spatial changes in elastic modulus of the sample. This method is computationally intensive and limited to displacements small enough to keep the two speckle patterns sufficiently correlated.…”

Section: Oct Elastographymentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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OCT-based arterial elastography: robust estimation exploiting tissue biomechanics

Cited by 93 publications

References 16 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence elastography – OCT at work in tissue biomechanics [Invited]

Optical coherence tomography—current technology and applications in clinical and biomedical research

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