Ocotea pulchellaas an alternative against schistosomiasis: chemical analysis, development of nanoemulsion and biological control activity

Passos, Bruno Goulart; Rangel, Leonardo da Silva; Albuquerque, Ricardo Diego Duarte Galhardo de; Caldas, Gabriel Rocha; Santos, Marcelo Guerra; Esteves, Ricardo dos Santos; Milton, Flora Aparecida; Neves, Francisco de Assis Rocha; Ruppelt, Bettina Monika; Santos, José Augusto Albuquerque dos; Faria, Robson Xavier; Rocha, Leandro

doi:10.37360/blacpma.20.19.5.35

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…In this context, nanoemulsions present themselves as a potential research field to enable these actives in an aqueous medium, especially essential oils. A few authors described similar nanotechnological approaches with nanoemulsions from Xylopia ochrantha (Annonaceae) essential oil (24 h/LC50 = 50.9 µg/mL), Ocotea pulchella (Lauraceae) essential oil (24 h/LC50 = 45.8 µg/mL), and Sideroxylon obtusifolium (Sapotaceae) extract (24 h/LC50 = 75.2 µg/mL) against B. glabrata mollusks, thus corroborating the LC50 values found in our study [13,15,44].…”

Section: Resultsmentioning

confidence: 99%

Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion

et al. 2023

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Schistosomiasis is a tropical disease transmitted in an aqueous environment by cercariae from the Schistosoma genus. This disease affects 200 million people living in risk areas around the world. The control of schistosomiasis is realized by chemotherapy, wastewater sanitation, health education, and mollusk control using molluscicidal agents. This work evaluates the effects of a nanoemulsion containing essential oil from Myrciaria floribunda leaves as a molluscicidal and cercaricidal agent against Biomphalaria glabrata mollusks and Schistosoma mansoni cercariae. The Myrciaria floribunda essential oil from leaves showed nerolidol, β-selinene, 1,8 cineol, and zonarene as major constituents. The formulation study suggested the F3 formulation as the most promising nanoemulsion with polysorbate 20 and sorbitan monooleate 80 (4:1) with 5% (w/w) essential oil as it showed a smaller droplet size of approximately 100 nm with a PDI lower than 0.3 and prominent bluish reflection. Furthermore, this nanoemulsion showed stability after 200 days under refrigeration. The Myrciaria floribunda nanoemulsion showed LC50 values of 48.11 µg/mL, 29.66 µg/mL, and 47.02 µg/mL in Biomphalaria glabrata embryos, juveniles, and adult mollusks, respectively, after 48 h and 83.88 µg/mL for Schistosoma mansoni cercariae after 2 h. In addition, a survival of 80% was observed in Danio rerio, and the in silico toxicity assay showed lower overall human toxicity potential to the major compounds in the essential oil compared to the reference molluscicide niclosamide. These results suggest that the nanoemulsion of Myrciaria floribunda leaves may be a promising alternative for schistosomiasis control.

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Section: Resultsmentioning

confidence: 99%

Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion

et al. 2023

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“…In addition, the roots of fern (Nephrolepis exaltata) and swamp cinnamon (Ocotea pulchella) have also been reported to treat oral infections in this study. However, no reports of these plants for use in oral diseases have been reported in the literature; only cinnamon-do-brejo has been reported for schistosomiasis, a parasite that can affect humans 25 . Table 3 shows the findings of this study, grouping the different herbal medicines according to the indications reported by indigenous people.…”

Section: Discussionmentioning

confidence: 99%

Phytotherapy used in the Treatment of Oral Diseases: a Cross-Sectional Study in Indigenous Population

Silva¹,

Calcia

Daroit³

2023

Arch Health Invest

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Phytotherapy studies the pharmacological effects of plants with the therapeutic purpose of preventing, curing, or minimizing disease symptoms. The use of plants by indigenous people to treat health conditions has been documented since ancient times. This study aimed to report an indigenous community's herbal medicines for oral diseases. An online questionnaire was administered, in which the participant indicated the type of plant and the part used, the preparation form, the administration route, and the dental condition. Subsequently, a descriptive analysis was performed. Most study participants were women (n=72, 62.1%). Peppermint tea (21.5%) was the most used substance for mouthwash and halitosis (42.2%). The bark of Açoita (34.5%) and Aroeira (31.9%) were the most frequently used to treat dental pain. Regarding gingival diseases, most responded that they used Guamirim (64.5%). Only mallow tea was reported to treat canker sores (81%). However, for herpetic lesions, participants reported the application of clay in a wasp nest (Polistes canada), an insect present at the site (55.2%). Oral inflammation had the lowest reported use of herbal medicine, with Marcela tea being the most frequently used (10.3%). Finally, fern roots were the most frequently used for infections (32 %). In conclusion, indigenous people widely use phytotherapeutics to treat oral diseases. Learning about the use of herbal medicines in indigenous communities may increase the clinical applicability of these plants in the dental field and, in the future, serve as a basis for developing new drugs.

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“…[40] Nanoemulsions containing the EO from Ocotea pulchella also display molluscicidal (LC 50 = 45.78 ppm, LC 90 = 64.14 ppm after 24 h) and anticercarial (LC 90 = 86.69 ppm after 4 h) activities. At concentrations ranging from 40 to 100 ppm, these nanoemulsions also kill 100 % of the eggs after 24 h. [41] Recently, Augusto and co-workers investigated the effects of the EO from Eryngium triquetrum on S. mansoni and its intermediate snail host B. glabarata. The LC 90 and LC 50 values against adult B. glabrata snails of 1.02 and 0.61 ppm, respectively, are significantly lower than those of most of the well-characterized EOs.…”

Section: Introductionmentioning

confidence: 99%

Antischistosomal Activity of Essential Oils: An Updated Review

Crotti

Pagotti

Magalhães

et al. 2022

Chemistry & Biodiversity

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This review article covers literature on the antischistosomal activity of essential oils (EOs) between 2011 and 2021. Criteria for classifying results from in vitro schistosomicidal assays are proposed for the first time. Parameters to evaluate the in vitro antischistosomal potential of EOs other than their ability to cause the death of Schistosoma mansoni adult worms (e. g., couple separation, egg laying, and egg development inhibition) are also addressed and discussed.

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Ocotea pulchellaas an alternative against schistosomiasis: chemical analysis, development of nanoemulsion and biological control activity

Abstract: Ocotea pulchella as an alternative against schistosomiasis: chemical analysis, development of nanoemulsion and biological control activity [Ocotea pulchella como una alternativa ante esquistosomiasis: análisis químico, desarrollo de una nanoemulsión y actividad en control biológico]

Cited by 5 publications

References 25 publications

Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion

Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion

Phytotherapy used in the Treatment of Oral Diseases: a Cross-Sectional Study in Indigenous Population

Antischistosomal Activity of Essential Oils: An Updated Review

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