Ocorrência de hemoglobina S no estado de Mato Grosso do Sul, Brasil

Holsbach, Denise Rodrigues; Ivo, Maria Lúcia; Honer, Michael Robin; Rigo, L; Botelho, Carlos

doi:10.1590/s1676-24442008000400007

Cited by 10 publications

(10 citation statements)

References 11 publications

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“…Among those with altered genotypes, 2,602 (99.16%) newborns had sickle cell trait, and 16 (0.61%) had the genotype Hb SS [11].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy complications and perinatal outcomes of women with hemoglobinopathies

Salazar¹,

Ivo²,

Freitas³

et al. 2016

Int Arch Med

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Objective: To estimate the prevalence of gestational complications and perinatal outcomes in women with and without hemoglobinopathies.Method: This is a cross-sectional study with a quantitative approach, performed from 110 medical records of pregnant women who underwent prenatal, childbirth, postpartum and perinatal care in a gynecology and obstetrics service of the University Hospital at the Federal University of Mato Grosso do Sul, Brazil, between 2010 and2011. Results: Gestational complications in women with and without hemoglobinopathies in the variables: obstetric (preterm labor, preeclampsia, ruptured membranes for more than six hours (17.06 times; 12.19 times; 4.27 times respectively); clinical: urinary tract infection, heart failure, severe anemia (2.97 times; 12.6 times; 9.75 times, respectively), and perinatal: cesarean delivery, neonatal infection; the newborn in the neonatal intensive care unit; fetal death, stillbirth (1.57 times; 39.00 times; 12.19 times; 12.9 times; 9.75 times; respectively) were higher in the presence of hemoglobinopathies. Conclusion:The pregnancy outcomes of women with hemoglobinopathies, perinatal and their newborns showed a higher prevalence of complications than women without this change. Pregnancy Complications and Perinatal Outcomes of Women with Hemoglobinopathies ORIGINAL

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“…Among those with altered genotypes, 2,602 (99.16%) newborns had sickle cell trait, and 16 (0.61%) had the genotype Hb SS [11].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy complications and perinatal outcomes of women with hemoglobinopathies

Salazar¹,

Ivo²,

Freitas³

et al. 2016

Int Arch Med

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“…The presence of hemoglobin S (Hb S), prevailing in sickle cell disease, consists in a change that characterizes it as a structural hemoglobinopathy, whereas thalassemia is a synthesis hemoglobinopathy. Individuals with Hb S have predominated in the screenings performed in the state of Mato Grosso do Sul (MS) 2., 3.. In order to explain these findings, further research is needed.…”

Section: Introductionmentioning

confidence: 99%

“…Under the responsibility of the Instituto de Pesquisas, Ensino e Diagnóstico da Associação de Pais e Amigos dos Excepcionais (IPED-APAE), the program is in its Step II in the State of Mato Grosso do Sul. Coverage has been increasing in the State; in 2002, the program already screened 92.06% of newborns 2 . Since then, there have been no records of coverage of less than 87.41% 2 …”

Section: Introductionmentioning

confidence: 99%

Scope and efficiency of the newborn screening program in identifying hemoglobin S

Ivo

Araújo

Barbieri

et al. 2014

Revista Brasileira de Hematologia e Hemoterapia

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BackgroundIn 2001, the Brazilian Ministry of Health added hemoglobinopathies to the National Neonatal Screening Program to be implemented in three steps. In order to meet the proposed goals, it is crucial to establish periodic assessments of this program with the aim of monitoring its implementation.ObjectiveTo assess the scope and the efficiency of the stages of the National Newborn Screening Program in identifying hemoglobin S.MethodsA cross-sectional study was developed with the results of the heel prick test using the high performance liquid chromatography method for babies born in Mato Grosso do Sul from 2006 to 2010. The following variables were investigated: year, number of live births, total screening, coverage ratio, prevalence, time between the child birth and the blood collection; age at diagnosis; age at the time of the first consultation; and time between the diagnosis and the first appointment.ResultsOver the five years of the study, the mean coverage rate was 91.77%. The prevalences of hemoglobin FAS and hemoglobin FS were 1.65% and 0.011%, respectively. Blood samples from 43.48% of children were collected from the second to the seventh day. The age at diagnosis was within the first 28 days in 87.80% of the screened children. The lowest mean indices for the first consultation and the time between the diagnosis and the first appointment (58.8 and 46.4 days, respectively) occurred in 2010.ConclusionsThe scope of the National Neonatal Screening Program for hemoglobinopathies is good, with a large number of individuals being tested. Efficiency is a suitable indicator to assess the program steps. Three points are recommended: the training of the individuals involved, studies to assess the assistance provided to the affected child, and genetic counseling to the mothers.© 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. All rights reserved.

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“…However, genetic changes in hemoglobin also cause anemia, namely hemoglobinopathies. These are among the most common genetic mutations in the general population (2,4) . Nevertheless, they are not extensively studied as a cause of anemia in patients with kidney disease, despite the fact that there are studies that correlate the presence of sickle hemoglobin with kidney damage.…”

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confidence: 99%