Ocitocina em cesarianas. O que há de novo?

Abstract

Oxytocin is the uterotonic agent of choice in the prevention and treatment of postpartum uterine atony. Nevertheless, there is no consensus on the optimal dose and rate for use in cesarean sections. The use of high bolus doses (e.g., 10 IU of oxytocin) can determine deleterious cardiovascular changes for the patient, especially in situations of hypovolemia or low cardiac reserve. Furthermore, high doses of oxytocin for prolonged periods may lead to desensitization of oxytocin receptors in myometrium, resulting in clinical inefficiency.

Low-dose oxytocin - a safe strategy in postpartum hemorrhage

“…Yamaguchi et al . [5] observed that higher doses of oxytocin can cause receptor desensitization resulting ineffective action on uterine myometrium. In this study, the duration of the administration of oxytocin drip in the high-dose group was 8–12 h. Receptors became insensitive resulting the higher incidence of uterine atony in the high dose group with the longer duration of infusion the receptors became insensitive that will cause the uterine to be atony.…”