Ochronotic Arthropathy

Laskar, F. H.; Sargison, K. D.

doi:10.1302/0301-620x.52b4.653

Cited by 57 publications

(22 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extra-articular involvement is in the form of ocular symptoms, skin pigmentation, cardiac involvement, and genitourinary system involvement. [ 1 2 3 4 5 6 ] In the urine, HGA is oxidized by the oxygen in the air into benzoquinone acetate (BQA). Urine is normal in color when freshly passed, but on exposure to air BQA rapidly darkens urine to assume brownish-black color.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exogenous Ochronosis

Bhattar

Zawar²,

Godse

et al. 2015

Indian J Dermatol

View full text Add to dashboard Cite

Exogenous ochronosis (EO) is a cutaneous disorder characterized by blue-black pigmentation resulting as a complication of long-term application of skin-lightening creams containing hydroquinone but may also occur due to topical contact with phenol or resorcinol in dark-skinned individuals. It can also occur following the use of systemic antimalarials such as quinine. EO is clinically and histologically similar to its endogenous counterpart viz., alkaptonuria, which, however, exhibits systemic effects and is an inherited disorder. Dermoscopy and in vivo skin reflectance confocal microscopy are noninvasive in vivo diagnostic tools. It is very difficult to treat EO, a cosmetically disfiguring and troubling disorder with disappointing treatment options.

show abstract

Section: Introductionmentioning

confidence: 99%

“…It reduces cupric oxide and also silver nitrate solution. [ 1 2 3 4 5 6 ] This forms the basis of an important bedside screening test which will differentiate alkaptonuria from EO. [ 7 ]…”

Section: Introductionmentioning

confidence: 99%

Exogenous Ochronosis

Bhattar

Zawar²,

Godse

et al. 2015

Indian J Dermatol

View full text Add to dashboard Cite

show abstract

“…Calcification in the disc spaces is a prominent feature of the condition; earliest and most marked changes generally occur in the lumbar spine, later spreading to thoracic and cervical segments (Schumacher, 1989;Emel et al, 2000;Şahin et al, 2001;Farzannia et al, 2003). The process begins with sclerosis of the end-plates, and culminates in ankylosis (O'Brien et al, 1963;Laskar & Sargison, 1970;Borman et al, 2002;Farzannia et al, 2003;Cetinus et al, 2005). Calcified depositis in intervertebral discs are generally hydroxyapatite (Bywaters et al, 1970 Lagier & Sitaj, 1974), although calcium pyrophosphate dihydrate has also been reported (McClure et al, 1983).…”

Section: Discussionmentioning

confidence: 99%

“…The small joints of the hands and feet are characteristically spared (O'Brien et al, 1963;Borman et al, 2002). There may be calcified prostatic concretions, and calcification of the costal and upper respiratory tract cartilages (O'Brien et al, 1963;Laskar & Sargison, 1970;McClure et al, 1983). Calcified bodies may form in peri-articular soft tissue and may be several centimetres across (Cetinus et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Intervertebral chondrocalcinosis: an exercise in differential diagnosis in palaeopathology

Mays

Dungworth

2008

Intl J of Osteoarchaeology

View full text Add to dashboard Cite

Intervertebral chondrocalcinosis (calcification of intervertebral discs and associated structures) may arise from a variety of causes. This work presents a discussion of intervertebral chondrocalcinosis and the identification of its most probable cause in skeletal remains, using as a case study a skeleton of an elderly male from medieval Ipswich, UK. The skeleton is examined using gross observation and radiography, and the intervertebral calcifications are subject to chemical analysis. In addition to intervertebral chondrocalcinosis (which has resulted in ankylosis of lumbo-sacral segments), lesions identified include chondrocalcinosis at some synovial joints, various soft tissue calcified bodies, and severe osteoarthritis particularly at the gleno-humeral joints. Interpretation of the results of the chemical analysis of the calcified deposits is complicated by diagenesis, but they are most consistent with apatite and/ or whitlockite. Arriving at a most probable cause of the lesions in this case is difficult, but it is tentatively suggested that ochronosis may be the best diagnostic option.

show abstract

“…Kleinschmidt (1922), Garrod (1923), Hertz.blu;g (1945), Lichtenst.einand l<aphm (1954), Cooper andMQran. (1957), O'Brien et al (1963), McCollum and Odom (1965), Laskar and Sargison (1970) informed about arthrotic changes and fragmentation of joint cartilage in ochronosis. Surprisingly few studies exist on the electron microscopic level.…”

Section: Manochronosis Joint Cartilage Synovial Membrane Ochronotmentioning

confidence: 99%

Submicroscopic Structure of the Human Joint Cartilage and Synovial Membrane in Ochronosis

Horký¹

1981

Acta Vet. Brno

View full text Add to dashboard Cite

Horky D.: Submicroscopic Structure of the Human Joint Cartilage and SynovialMembrane in Ochronosis. Acta vet. Bmo,.50, 1981: 131-156.Using a transmission electron .lInd Sc8nning electron microscope the joint cartilage and synovial membrane were studied in 5 persons of the age from 30 to 55 years.In its majority the superficial cartilage layer is absent due to arthritic changes caused by the deposition of granules of ochronotic pigment in the intercellular substance of the cartilage. In regiOns with It well-preserved cartilage distinct sings of arthrosis are evident on its surface. In the cytoplasm of chondrocytes of the middle layer vesicleS appear filled with ochronotic pigment in variOus stages of polymerization. The aperiodic fibres which penetrate into· the proximity of the chondrocytes multiply so that the pericellular matrix disappears. A small amount of· granules ofthe ochronotic pigment is deposited in this area; whereas in the intercellular matrix they appear in a large amount both in the form of granules and in layers deposited between thick collagen fibres. In the deep . layer there are signs of degeneration of chondrocytes. In the cytoplasm autophagic vacuoles occur formed by pigment granules, secondary lysosomes, lipid droplets and cOncentrically layered membranes of the granular endoplasmic reticulum. In the scanning electron microscope deep defects are distinctly evident on the sUrface and empty chondrocyte capsules with mound-like contoured edges. Both oil the bottom of these capsules and on the surface of the cartilage deposited are crystals of ochronotic pigment, cell debris and solitary cells. Short sections of the synovial membrane are covered with a confluent layer of cells of a transient type. No pigment occurs in the thus arranged synovial membrane. The major part of the synovial membrane surface is pigment with a layer of intercellular substance in which granules of oChronotic covered are deposited. Nearer to the surface the synovialocytes resemble fibrocytes and small amounts. of granules of pigment occur in' their cytoplasm. Synovialocytes situated deeper are of intennediary type and in their cytoplasm pigmen!; is deposited in the form of large deposits of. as much as 2 pm in size. Man,ochronosis, joint cartilage, synovial membrane, ochrOnotic pigment.

show abstract

Ochronotic Arthropathy

Cited by 57 publications

References 30 publications

Exogenous Ochronosis

Exogenous Ochronosis

Intervertebral chondrocalcinosis: an exercise in differential diagnosis in palaeopathology

Submicroscopic Structure of the Human Joint Cartilage and Synovial Membrane in Ochronosis

Contact Info

Product

Resources

About