Ochrobactrum anthropi Infection of the Hand

Abstract

Ochrobactrum anthropi is an opportunistic, low-virulence pathogen occasionally associated with human infections and found largely in immunocompromised patients and those with intravascular devices. We report the case of a healthy 70-year-old man who presented with an infection of the hand, who had no history of trauma but had been gardening for 4 months. Despite surgical debridement and empirical antibiotics, the infection could not be controlled. Cultures revealed O anthropi. Antibiotic treatment was adapted to intravenous cefepime for 15 days and the infection was finally controlled after a second surgery. Oral cotrimoxazole was continued for another 2 weeks. Ochrobactrum anthropi infection of the hand must be considered not only in immunosuppressed patients but also in healthy patients without intravascular devices. Local debridement and empiric antibiotic may be insufficient. Antibiotic therapy should follow susceptibility testing, but usually includes a broad-spectrum intravenous beta-lactam such as imipenemecilastatin or cefepime, or oral cotrimoxazole or ciprofloxacin.

Ochrobactrum anthropi sepsis in a 15‐month‐old child: A case report

“… 24 It is usually an opportunistic, low‐virulence pathogen occasionally associated with human infections and reported commonly with immunocompromised patients or patients with intravascular devices. 25 Cases associated with indwelling vascular catheters, Gullain–Barre syndrome, neonatal sepsis with prematurity, meningitis from nosocomial infections and pneumonia have been described. 2 , 23 , 26 , 27 , 28 Antibiotic susceptibility varies, but it is generally susceptible to co‐trimoxazole, quinolones, and aminoglycosides, particularly gentamicin.…”

“…It may also be part of the normal gastrointestinal tract flora 24 . It is usually an opportunistic, low‐virulence pathogen occasionally associated with human infections and reported commonly with immunocompromised patients or patients with intravascular devices 25 . Cases associated with indwelling vascular catheters, Gullain–Barre syndrome, neonatal sepsis with prematurity, meningitis from nosocomial infections and pneumonia have been described 2,23,26–28 .…”

Analysis of changes in bacterial diversity in healthy and bacterial wilt mulberry samples using metagenomic sequencing and culture-dependent approaches

“…In addition, the culture-dependent method revealed that the abundance of many opportunistic pathogens and drug-resistant bacteria was significantly higher in the xylem of the diseased samples compared to their healthy counterparts. Infections in humans have been reported mostly with opportunistic pathogens, including Achromobacter ( Menetrey et al., 2021 ), Acinetobacter ( Amorim and Nascimento, 2017 ) , Brucella ( Roop et al., 2021 ), Delftia ( Deb et al., 2020 ), Escherichia ( Bhatt et al., 2019 ), Herbaspirillum ( Bloise et al., 2021 ), Klebsiella ( Rodríguez–Medina et al., 2019 ), Ochrobactrum ( Bratschi et al., 2020 ), Pantoea ( Cobo et al., 2021 ), Ralstonia ( Ryan and Adley, 2014 ) and Stenotrophomonas ( Menetrey et al., 2021 ). Moreover, Acinetobacter ( Shin et al., 2020 ), Escherichia ( Tang et al., 2022 ), Klebsiella ( Dong et al., 2022 ), Pantoea ( Yoshimura et al., 2022 ) and Stenotrophomonas ( Ferreira et al., 2020 ) have been shown to have multidrug resistance.…”