Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin – Modulation by Nrf2

Ramyaa, Periasamy; Padma, Viswanadha Vijaya

doi:10.1016/j.fct.2013.08.048

Cited by 72 publications

(55 citation statements)

References 61 publications

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“…The current study showed that luteolin is able to partly reverse the effects of TNF-α on the level of GSH and activity of SOD in HUVECs. These enzymes are involved in ROS scavenging 29) and associated with the important transcription factor Nrf-2, which binds to the antioxidant response element in the promoter region of many genes 26) ; therefore, this may be another mechanism underlying the decrease in intracellular ROS production mediated by luteolin.…”

Section: Discussionmentioning

confidence: 99%

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Luteolin Protects HUVECs from TNF-α-induced Oxidative Stress and Inflammation via its Effects on the Nox4/ROS-NF-κB and MAPK Pathways

Xia

Wang

Jin

et al. 2014

JAT

128

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Aim: Inflammation and oxidative stress are now recognized to be two important contributing factors to the development of atherosclerosis (AS). NADPH oxidase-4 (Nox4)-derived reactive oxygen species (ROS), NF-κB and MAPK play crucial roles in these processes. Luteolin, a flavone rich in many plants, can interrupt the molecular expression and inhibit the progression of inflammation and oxidative stress. The present study was designed to test whether luteolin inhibits TNF-α-induced inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs) and identify some of the mechanisms underlying these effects.

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Section: Discussionmentioning

confidence: 99%

“…ROS are the main products of oxidative stress and participate in apoptosis and inflammation 26) . Low to moderate levels of ROS have been shown to contribute to important functions, such as cell differentiation, migration, adhesion, senescence, growth and apoptosis.…”

Section: Effects Of the Signaling Mechanism(s) Of Tnf-α On The Icam-1mentioning

confidence: 99%

Luteolin Protects HUVECs from TNF-α-induced Oxidative Stress and Inflammation via its Effects on the Nox4/ROS-NF-κB and MAPK Pathways

Xia

Wang

Jin

et al. 2014

JAT

128

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“…Different doses of OTA (BioPure Technology, UK) (0, 5, 10, 50, 75, 100 and 125 g/mL) were tested. The selection of OTA doses was supported by other in vitro studies in Vero cells (Ramyaa and Padma, 2013). The polyphenols luteolin (≥98%), chlorogenic acid (≥95%) or caffeic acid (≥ 98%) (all fom Sigma St. Louis, USA) were also tested in different doses (0, 10, 25, 50, 100 and 200 g/mL).…”

Section: Cytotoxicity On Vero Cellsmentioning

confidence: 99%

Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A

Cariddi

Sabini

Escobar

et al. 2015

Environmental Toxicology and Pharmacology

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“…catechin, quercetin or luteolin) [48][49][50]. It is also supported by the study of Ramyaa and Padma [51] where OTA-induced oxidative stress was substantially alleviated by quercetin. However, none of the other tested flavonoids caused significant elevation of ATP levels in OTA-exposed cells (data not shown).…”

Section: Diosmetin Versus Atp Depleting Effect Of Ochratoxin Amentioning

confidence: 75%

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

Poór

Veres

Jakus

et al. 2014

Journal of Photochemistry and Photobiology B: Biology

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a b s t r a c tDiosmetin (DIOS) is a flavone aglycone commonly occurring in citrus species and olive leaves, in addition it is one of the active ingredients of some medications. Based on both in vitro and in vivo studies several beneficial effects are attributed to DIOS but the biochemical background of its action seems to be complex and it has not been completely explored yet. Previous investigations suggest that most of the flavonoid aglycones have negative effect on ATP synthesis in a dose dependent manner. In our study 17 flavonoids were tested and interestingly DIOS caused a significant elevation of intracellular ATP levels after 6-and 12-h incubation in MDCK kidney cells. In order to understand the mechanism of action, intracellular ATP and protein levels, ATP/ADP ratio, cell viability and ROS levels were determined after DIOS treatment. In addition, impacts of different enzyme inhibitors and effect of DIOS on isolated rat liver mitochondria were also tested. Finally, the influence of DIOS on the ATP depleting effect of the mycotoxin, ochratoxin A was also investigated. Our major conclusions are the followings: DIOS increases intracellular ATP levels both in kidney and in liver cells. Inhibition of glycolysis or citric acid cycle does not decrease the observed effect. DIOS-induced elevation of ATP levels is completely abolished by the inhibition of ATP synthase. DIOS is able to completely reverse the ATP-depleting effect of the mycotoxin, ochratoxin A. Most probably the DIOS-induced impact on ATP system does not originate from the antioxidant property of DIOS. Based on our findings DIOS may be promising agent to positively influence ATP depletion caused by some metabolic poisons.

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Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin – Modulation by Nrf2

Cited by 72 publications

References 61 publications

Luteolin Protects HUVECs from TNF-α-induced Oxidative Stress and Inflammation via its Effects on the Nox4/ROS-NF-κB and MAPK Pathways

Luteolin Protects HUVECs from TNF-α-induced Oxidative Stress and Inflammation via its Effects on the Nox4/ROS-NF-κB and MAPK Pathways

Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A

Flavonoid diosmetin increases ATP levels in kidney cells and relieves ATP depleting effect of ochratoxin A

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