Ochratoxin A production by Penicillium thymicola

Nguyen, Hai D. T.; McMullin, David; Пономарева, Екатерина; Riley, Robert; Pomraning, Kyle R.; Baker, Scott E.; Seifert, Keith A.

doi:10.1016/j.funbio.2016.04.002

Cited by 22 publications

(13 citation statements)

References 54 publications

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“…No study has been conducted where each gene in an identified OTA gene cluster was knocked out. It is not yet clear which genes, or protein domains, found within an OTA biosynthetic gene cluster are essential for its production 13 .…”

Section: Introductionmentioning

confidence: 99%

Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius

Castellá

Bragulat

Puig

et al. 2018

Sci Rep

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Ochratoxin A (OTA) is a mycotoxin with nephrotoxic effects on animals and humans. Aspergillus carbonarius is the main responsible for OTA contamination of grapes and derived products. We present the genome resequencing of four A. carbonarius strains, one OTA producer and three atypical and unique non-OTA producing strains. These strains were sequenced using Illumina technology and compared with a reference genome of this species. We performed some specific bioinformatics analyses in genes involved in OTA biosynthesis. Data obtained in this study revealed the high genomic diversity within A. carbonarius strains. Although some gaps of more than 1,000 bp were identified in non-ochratoxigenic strains, no large deletions in functional genes related with OTA production were found. Moreover, the expression of five genes of the putative OTA biosynthetic cluster was down regulated under OTA-inducing conditions in the non-ochratoxigenic strains. Knowledge of the regulatory mechanisms involved in OTA biosynthesis will provide a deeper understanding of these non-ochratoxigenic strains.

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Section: Introductionmentioning

confidence: 99%

Genomic diversity in ochratoxigenic and non ochratoxigenic strains of Aspergillus carbonarius

Castellá

Bragulat

Puig

et al. 2018

Sci Rep

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“…likely to be a stable contributor to high OTA level in liquorice. However, none of these species are considered OTA producers [47,59]. This should be confirmed using proper chromatographic detection of OTA and accurate identification of the fungi.…”

Section: Ota Producing Species In the Black Aspergillimentioning

confidence: 98%

Black aspergilli and ochratoxin A-producing species in foods

Cabañes

Bragulat

2018

Current Opinion in Food Science

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Ochratoxin A (OTA) is a potent nephrotoxin and carcinogen which is found in a wide variety of common foods and beverages. The black aspergilli are distributed worldwide and are regarded as common food spoilage fungi. These fungi are one of the more difficult groups concerning classification and identification. New molecular approaches have shown that there is a high biodiversity, but that species are occasionally difficult to recognize based solely on their phenotypic characters. Only few species have been confirmed to be OTA producers in this group and fewer are known to contaminate foods with this mycotoxin as a natural occurring contaminant. In this paper, the OTA-producing species included in the Aspergillus section Nigri and the foods that they are able to contaminate are reviewed in depth.

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“…Both P. verrucosum and P. viridicatum are able to produce the mycotoxin citrinin, but P. verrucosum is also a producer of the mycotoxin ochratoxin ( 3 , 4 ). Nowadays, P. verrucosum belongs to the series Verrucosa within the section Fasciculata together with Penicillium nordicum and Penicillium thymicola ( 5 , 6 ). P. verrucosum is psychrotolerant and occurs mainly in moderate-temperature regions, such as Northern Europe, North America, Canada, and parts of South America.…”

Section: Announcementmentioning

confidence: 99%