Ochratoxicosis in poultry: occurrence, environmental factors, pathological alterations and amelioration strategies

Tahir, Muhammad Ali; Abbas, Amjad; Muneeb, Muhammad; Bilal, Rana Muhammad; Hussain, Kashif; Abdel-Moneim, Abdel-Moneim Eid; Farag, Mayada R.; Dhama, Kuldeep; Elnesr, Shaaban S.; Alagawany, Mahmoud

doi:10.1080/00439339.2022.2090887

Cited by 11 publications

(9 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These toxins can be found in various climates, including warmer regions like A. ochraceous and colder regions like P. verrucosum [ 126 ]. Unlike aflatoxins, ochratoxins have been found to cause more toxicity in broilers and layers [ 127 ]. The toxicological profile of Ochratoxins classifies them as carcinogenic, nephrotoxic, teratogenic, immunotoxic, and mutagenic.…”

Section: Major Types Of Mycotoxins and Their Masked Forms In Chickensmentioning

confidence: 99%

“…The undesirable effects of ochratoxins on poultry feed are twofold: they adversely affect the growth and quality of eggs and meat, and they also lead to economic losses by impacting the bird’s productive performance. Furthermore, these toxins cause histopathological changes in the organs of birds, which further deteriorates their overall health [ 127 ].…”

Section: Major Types Of Mycotoxins and Their Masked Forms In Chickensmentioning

confidence: 99%

See 1 more Smart Citation

Hidden Hazards Revealed: Mycotoxins and Their Masked Forms in Poultry

Okasha,

Song,

Song

2024

Toxins

View full text Add to dashboard Cite

The presence of mycotoxins and their masked forms in chicken feed poses a significant threat to both productivity and health. This review examines the multifaceted impacts of mycotoxins on various aspects of chicken well-being, encompassing feed efficiency, growth, immunity, antioxidants, blood biochemistry, and internal organs. Mycotoxins, toxic substances produced by fungi, can exert detrimental effects even at low levels of contamination. The hidden or masked forms of mycotoxins further complicate the situation, as they are not easily detected by conventional methods but can be converted into their toxic forms during digestion. Consequently, chickens are exposed to mycotoxin-related risks despite apparently low mycotoxin levels. The consequences of mycotoxin exposure in chickens include reduced feed efficiency, compromised growth rates, impaired immune function, altered antioxidant levels, disturbances in blood biochemical parameters, and adverse effects on internal organs. To mitigate these impacts, effective management strategies are essential, such as routine monitoring of feed ingredients and finished feeds, adherence to proper storage practices, and the implementation of feed detoxification methods and mycotoxin binders. Raising awareness of these hidden hazards is crucial for safeguarding chicken productivity and health.

show abstract

Section: Major Types Of Mycotoxins and Their Masked Forms In Chickensmentioning

confidence: 99%

Section: Major Types Of Mycotoxins and Their Masked Forms In Chickensmentioning

confidence: 99%

Hidden Hazards Revealed: Mycotoxins and Their Masked Forms in Poultry

Okasha,

Song,

Song

2024

Toxins

View full text Add to dashboard Cite

show abstract

“…Mycotoxins are fungi’s corrosive and cytotoxic metabolites and are considered widespread pollutants in the feed materials [ 1 , 2 ]. According to statistics, one-fourth of the feed components produced globally contain mycotoxins [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits

Hassan

Abo-Elmaaty

Zaglool

et al. 2023

Toxins

Self Cite

View full text Add to dashboard Cite

The current study was performed to investigate the toxic effects of aflatoxin B1 (AFB1) through the evaluation of kidney function tests and histopathological examination of renal tissues, targeting the therapeutic role of Marjoram (Origanum vulgare essential oil-OEO) in improving health status. Forty-eight New Zealand Whites growing rabbits (four weeks old) weighing on average 660.5 ± 2.33 g were randomly and equally distributed into four groups, each of which had four replicas of three animals as the following: Control group (only basal diet), AFB1 group (0.3 mg AFB1/kg diet), OEO group (1 g OEO/kg diet) and co-exposed group (1 g OEO/kg + 0.3 mg AF/kg diet). Our study lasted eight weeks and was completed at 12 weeks of age. The results revealed that OEO decreased the toxic effects of AFB1 in rabbit kidneys by substantially reducing the cystatin C levels in the AFB1 group. Additionally, OEO decreased oxidative stress and lipid peroxidation levels in the co-exposed group. Moreover, OEO reduced DNA damage and inflammatory response in addition to the down-regulation of stress and inflammatory cytokines-encoding genes. Besides, OEO preserved the cytoarchitecture of rabbits’ kidneys treated with AFB1. In conclusion, O. vulgare essential oil supplementation ameliorated the deleterious effects of AFB1 on the rabbits’ kidneys by raising antioxidant levels, decreasing inflammation, and reversing oxidative DNA damage.

show abstract

“…Ochratoxin A (OTA) is a mycotoxin produced mainly by Aspergillus and Penicillium molds. OTA is a common contaminant in cereals, mainly oats and barley, as well as in animal feed derived from these grains [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…OTA acts as a competitive inhibitor of carrier proteins on the inner mitochondrial membrane, inhibiting mitochondrial respiration. Although OTA is considered a potent teratogenic agent for chickens, it does not have the same effect on other domestic animals [ 8 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Silica–Calcite Sedimentary Rock (Opoka) Enhances the Immunological Status and Improves the Growth Rate in Broilers Exposed to Ochratoxin A in Feed

Makarski,

Piotrowska,

Żbikowski

et al. 2023

Animals

View full text Add to dashboard Cite

Mycotoxins, such as Ochratoxin A (OTA), originating from fungi like Aspergillus and Penicillium, represent serious health hazards to poultry. The use of mycotoxin-adsorbing feed additives can reduce these risks. Opoka, a porous transitional rock, shows promise as one of these additives. This study is the first to examine the effect of Opoka administered with OTA on zootechnical parameters and the immune response of chickens. A 42-day investigation examined the impact of 1% of Opoka supplementation in feed on OTA-challenged broiler chickens. Seventy-two chickens were allocated into three groups of twenty-four individuals each: a control group, an OTA-exposed (2 mg/kg feed) group, and an OTA (2 mg/kg feed) plus 1% of Opoka group. Growth and blood parameters were monitored at predetermined intervals, and comprehensive biochemical, hematological, and cytometric analyses were conducted. The study showed that OTA exposure had a negative impact on chicken weight gain. However, adding Opoka to the diet improved weight gain, indicating its potential as a protective agent. Chickens fed with Opoka also had an increased white blood cell count, which suggests an improved immune response and elevated glucose and cholesterol concentrations. These findings indicate that Opoka may be useful in mitigating health complications caused by OTA exposure in broilers.

show abstract

Ochratoxicosis in poultry: occurrence, environmental factors, pathological alterations and amelioration strategies

Cited by 11 publications

References 101 publications

Hidden Hazards Revealed: Mycotoxins and Their Masked Forms in Poultry

Hidden Hazards Revealed: Mycotoxins and Their Masked Forms in Poultry

Origanum vulgare Essential Oil Modulates the AFB1-Induced Oxidative Damages, Nephropathy, and Altered Inflammatory Responses in Growing Rabbits

Silica–Calcite Sedimentary Rock (Opoka) Enhances the Immunological Status and Improves the Growth Rate in Broilers Exposed to Ochratoxin A in Feed

Contact Info

Product

Resources

About