Ocfentanil in France: Seven case reports (2016–2018)

Allibe, Nathalie; Billault, Francis; Moreau, Cécile; Marchard, Amandine; Gaillard, Yvan; Hoizey, Guillaume; Eysseric-Guerin, Hélène; Milan, Nathalie

doi:10.1016/j.toxac.2018.12.003

Cited by 6 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cited reference with the highest burst strengths in this cluster focuses on fentanyl and other novel synthetic opioids [34, 146, 147], supporting this notion. Many citing articles were concerned with opioid-related deaths [39, 148, 149, 150] and a significant number of articles pointed towards the rapidly surging numbers globally and its implications on public health [151, 152, 153].…”

Section: Discussionmentioning

confidence: 99%

The Novel Psychoactive Substances Epidemic: a Scientometric Perspective

Neoh

Carollo

Lim

et al. 2022

Preprint

View full text Add to dashboard Cite

The unprecedented proliferation of novel psychoactive substances (NPS) in the illicit drug market has been a public health concern since their emergence in the 2000s. Their consumption can pose a severe health risks as their mechanism of action is poorly understood and their level of toxicity is high mainly due to the diffusion of very potent synthetic cannabinoids and synthetic opioids. This study systemically analyses the evolution of the scientific literature on NPS to gain a better understanding of the areas of major research interests and how they interlink. Findings indicate that the published evidence covers clusters focused on classes of NPS that have received widespread media attention, such as mephedrone and fentanyl, and have largely been concerned with the pharmacological and the toxicological profiles of these substances. This scientometric perspective also provides greater insight into the knowledge gaps within this new and rapidly growing field of study and highlights the need for an interdisciplinary approach in tackling the NPS epidemic.

show abstract

Section: Discussionmentioning

confidence: 99%

The Novel Psychoactive Substances Epidemic: a Scientometric Perspective

Neoh

Carollo

Lim

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Even though cases of death due to OCF were reported [ 9 , 22 , 32 , 46 - 48 ], deaths were non-witnessed and cannot provide a picture of the symptoms. The low number of non-fatal intoxications does not speak in favor of low toxicity of the compound, and, given the described sudden loss of consciousness reported after snorting OCF [ 41 ], the possibility of fatal collapses while driving has to be considered.…”

Section: Psychomotor Performances In Humans - Literature Reviewmentioning

confidence: 99%

Sensorimotor Alterations Induced by Novel Fentanyl Analogs in Mice: Possible Impact on Human Driving Performances

Marti

Bilel

Giorgetti

et al. 2023

View full text Add to dashboard Cite

Operating a vehicle is a complex task that requires multiple cognitive functions and psychomotor skills to cooperate. Driving might be impaired by licit or illicit drugs, including novel psychoactive substances (NPS) and novel synthetic opioids (NSO), the effects of which are still yet to be elucidated in humans. In the present work, a revision of the literature regarding the psychomotor impairing effects of Fentanyl (FENT) and three analogues (Acrylfentanyl, Ocfentanyl and Furanylfentanyl) is presented, as emerged by experimental studies on humans, driving under the influence of a drug (DUID) and intoxication cases. An experimental study on a mouse model evaluated the sensorimotor alterations induced by FENT and the three fentalogs. Acute systemic administration of the four opioids (0.01-15 mg/kg i.p.) dose-dependently decreased the visual object and placing tests, the acoustic and the tactile responses of mice. The preclinical data are in accordance with the data that emerged from the revision of the literature regarding experimental data on humans, driving under the influence of drugs and intoxication cases, suggesting that novel synthetic opioids might affect the psychomotor performances on daily human tasks with a particular focus on driving.

show abstract

“…Ocfentanil was reported to be an adulterant in heroin [ 230 ]. Several fatal cases associated with ocfentanil were reported in recent years [ 229 , [231] , [232] , [233] , [234] ]. Misailidi et al.…”

Section: Challenges – Selected Topic Of Forensic Interestsmentioning

confidence: 99%