Ocena wpływu dawki i mocy promieniowania jonizującego na komórki raka piersi. The assessment  of the effect of ionizing radiation dose and dose rate for breast cancer cells

Musielak, Marika

doi:10.21641/los.15.4.82

Cited by 3 publications

(2 citation statements)

References 40 publications

(35 reference statements)

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“…A clonogenic assay was performed as described elsewhere [ 24 , 25 ]. Briefly, after irradiation, the cells were counted using a Luna II automated cell counter (Logos Biosystems) plated on 6-well plates and incubated for 10–14 days.…”

Section: Methodsmentioning

confidence: 99%

Verification of electron beam parameters in an intraoperative linear accelerator using dosimetric and radiobiological response methods

Dróżdż

Waluś

Zieliński

et al. 2021

Rep Pract Oncol Radiother.

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Background The availability of linear accelerators (linac) for research purposes is often limited and therefore alternative radiation sources are needed to conduct radiobiological research. The National Centre for Radiation Research in Poland recently developed an intraoperative mobile linac that enables electron irradiation at energies ranging from 4 to 12 MeV and dose rates of 5 or 10 Gy/min. The present study was conducted to evaluate the electron beam parameters of this intraoperative linac and to verify the set-up to evaluate out-of-field doses in a water phantom, which were determined through dosimetric and biological response measurements. Materials and methods The distribution of radiation doses along and across the radiation beam were measured in a water phantom using a semiconductor detector and absolute doses using an ionisation chamber. Two luminal breast cancer cell lines (T-47D and HER2 positive SK-BR-3) were placed in the phantom to study radiation response at doses ranging from 2 to 10 Gy. Cell response was measured by clonogenic assays. Results and Conclusion The electron beam properties, including depth doses and profiles, were within expected range for the stated energies. These results confirm the viability of this device and set-up as a source of megavoltage electrons to evaluate the radiobiological response of tumour cells.

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Section: Methodsmentioning

confidence: 99%

Verification of electron beam parameters in an intraoperative linear accelerator using dosimetric and radiobiological response methods

Dróżdż

Waluś

Zieliński

et al. 2021

Rep Pract Oncol Radiother.

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“…Conventional treatment of cancer includes surgery, chemotherapy, and radiation therapy. Many different factors are used to sensitize cancer cells to ionizing radiation while protecting the percentage of normal cells in the field of the therapeutic beam [39]. Metallic nanoparticles are usually used as agents sensitizing cancer cells to ionizing radiation during radiotherapy [40].…”

Section: Treatmentmentioning

confidence: 99%

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Musielak

Potoczny

Boś-Liedke

et al. 2021

IJMS

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Nanotechnology has introduced a new quality and has definitely developed the possibilities of treating and diagnosing various diseases. One of the scientists’ interests is liposomes and metallic nanoparticles (LipoMNPs)—the combination of which has introduced new properties and applications. However, the field of creating hybrid nanostructures consisting of liposomes and metallic nanoparticles is relatively little understood. The purpose of this review was to compile the latest reports in the field of treatment and medical imaging using of LipoMNPs. The authors focused on presenting this issue in the direction of improving the used conventional treatment and imaging methods. Most of all, the nature of bio-interactions between nanostructures and cells is not sufficiently taken into account. As a result, overcoming the existing limitations in the implementation of such solutions in the clinic is difficult. We concluded that hybrid nanostructures are used in a very wide range, especially in the treatment of cancer and magnetic resonance imaging. There were also solutions that combine treatments with simultaneous imaging, creating a theragnostic approach. In the future, researchers should focus on the description of the biological interactions and the long-term effects of the nanostructures to use LipoMNPs in the treatment of patients.

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Historia zastosowania promieniowania protonowego w radioterapii

Musielak¹

2022

LOS

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Historia terapii protonowej rozpoczęła się w 1946 roku kiedy Robert Wilson opublikował artykuł, w którym zaproponował wykorzystanie akceleratorów formujących wiązkę protonową do leczenia głęboko zlokalizowanych guzów. W konwencjonalnej radioterapii wykorzystywane jest promieniowanie fotonowe. Opisując przewagę promieniowania protonowego nad fotonowym należy zwrócić uwagę na jego aspekty fizyczne m.in. rozkład głębokościowy dawki. Rozkład dawki w ośrodku maleje wykładniczo dla fotonów, natomiast dla protonów rozkład głębokości dawki ma charakterystyczny kształt, zwany pikiem Bragga. Celem pracy jest przedstawienie historii terapii protonowej rozpoczynając od odkrycia protonu, a kończąc na współczesnej radioterapii klinicznej. W 1990 rozpoczęła się nowoczesna era terapii wykorzystujących cząstki, kiedy został otwarty pierwszy specjalistyczny szpital leczący terapią protonową w Centrum Medycznym Uniwersytetu Loma Linda w Kalifornii. Od tamtej pory leczenie protonowe było przeprowadzane w placówkach szpitalnych używając technologii i technik, które były porównywalne z nowoczesną radioterapią fotonową. Dane kliniczne jednoznacznie potwierdzały, że terapia protonowa jest przodującą i lepszą metodą leczenia od konwencjonalnej radioterapii. W tym okresie pacjenci byli leczeni w kilku ośrodkach na świecie, gdzie metody i techniki napromieniania były różne, a nowe technologie były stale implementowane. Finalnie, dane kliniczne uzyskane w naukowych placówkach wykazały dobrą powtarzalność i wydajność terapii protonowej.

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Ocena wpływu dawki i mocy promieniowania jonizującego na komórki raka piersi. The assessment of the effect of ionizing radiation dose and dose rate for breast cancer cells

Cited by 3 publications

References 40 publications

Verification of electron beam parameters in an intraoperative linear accelerator using dosimetric and radiobiological response methods

Verification of electron beam parameters in an intraoperative linear accelerator using dosimetric and radiobiological response methods

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Historia zastosowania promieniowania protonowego w radioterapii

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