Occurrence, sources and environmental risk assessment of pharmaceuticals in the Sea of Marmara, Turkey

Korkmaz, Nagihan E.; Savun-Hekimoğlu, Başak; Aksu, Abdullah; Burak, Selmin; Caglar, Nuray Balkis

doi:10.1016/j.scitotenv.2022.152996

Cited by 24 publications

(5 citation statements)

References 101 publications

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“…Among the PHACs are ofloxacin, norfloxacin, sulfamethoxazole, erythromycin, carbamazepine, roxithromycin, diclofenac, ciprofloxacin, caffeine, ibuprofen, metoprolol, bezafibrate, salicylic acid, and naproxen, while the EDCs include estrone and bisphenol A. The high ecological risks of these ECs have also been extensively documented in other studies (e.g., ofloxacin [26][27][28][29], norfloxacin [26,28,30,31], sulfamethoxazole [32][33][34], erythromycin [35][36][37], carbamazepine [32,[38][39][40][41], roxithromycin [42][43][44][45], diclofenac [46][47][48], ciprofloxacin [49,50], caffeine [51][52][53][54], ibuprofen [38,[55][56][57], metoprolol [58,59], bezafibrate [60,61], salicylic acid [62], naproxen [63][64][65], estrone [66][67]…”

Section: Riskmentioning

confidence: 99%

Emerging Contaminants in the Effluent of Wastewater Should Be Regulated: Which and to What Extent?

Yang,

Bu,

Shi

et al. 2024

Toxics

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Effluent discharged from urban wastewater treatment plants (WWTPs) is a major source of emerging contaminants (ECs) requiring effective regulation. To this end, we collected discharge datasets of pharmaceuticals (PHACs) and endocrine-disrupting chemicals (EDCs), representing two primary categories of ECs, from Chinese WWTP effluent from 2012 to 2022 to establish an exposure database. Moreover, high-risk ECs’ long-term water quality criteria (LWQC) were derived using the species sensitivity distribution (SSD) method. A total of 140 ECs (124 PHACs and 16 EDCs) were identified, with concentrations ranging from N.D. (not detected) to 706 μg/L. Most data were concentrated in coastal regions and Gansu, with high ecological risk observed in Gansu, Hebei, Shandong, Guangdong, and Hong Kong. Using the assessment factor (AF) method, 18 high-risk ECs requiring regulation were identified. However, only three of them, namely carbamazepine, ibuprofen, and bisphenol-A, met the derivation requirements of the SSD method. The LWQC for these three ECs were determined as 96.4, 1010, and 288 ng/L, respectively. Exposure data for carbamazepine and bisphenol-A surpassed their derived LWQC, indicating a need for heightened attention to these contaminants. This study elucidates the occurrence and risks of ECs in Chinese WWTPs and provides theoretical and data foundations for EC management in urban sewage facilities.

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Section: Riskmentioning

confidence: 99%

Emerging Contaminants in the Effluent of Wastewater Should Be Regulated: Which and to What Extent?

Yang,

Bu,

Shi

et al. 2024

Toxics

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“…51 In North America, concentrations of up to 2300 ng L À1 were found in the USA, 42 and in the Asian continent, 1840 ng L À1 in Turkey. 52 This compound is a dibenzodiazepine used as an anticonvulsant and its presence in environmental matrices has been related to incomplete metabolism in the body, excessive use by people and its persistence in the environment (half life time of up to 120 days), in addition to the fact that it is one of the drugs with a low degradation efficiency at WWTPs (<10%). Non-Steroidal Anti-Inammatory Drugs -NSAIDs (diclofenac, ibuprofen, acetaminophen, naproxen and ketoprofen) were the most found pharmaceutical group in surface water.…”

Section: Surface Watermentioning

confidence: 99%

Updated knowledge, partitioning and ecological risk of pharmaceuticals and personal care products in global aquatic environments

Chaves

Külzer

Lima

et al. 2022

Environ. Sci.: Processes Impacts

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“…ABXs, once consumed, become part of human and animal excretion, which constitute the main source of antibiotic release into the environment (approximately 80-90% of the total). These ABX residues can be directed to wastewater treatment plants (WWTPs) but, due their physicochemical properties, they cannot be partially or fully degraded via conventional treatments [3], allowing them to enter water bodies when wastewater is discharged into the environment [4][5][6][7]. Consequently, the amount and variety of ABXs, their metabolites, and degradation products that end up in various aquatic environmental compartments increase at a disturbing pace every year.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Ecotoxicity of Eight Widely Used Antibiotics on River Microbial Communities

Pino-Otín,

Lorca,

Langa

et al. 2023

IJMS

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Global prevalence of antibiotic residues (ABX) in rivers requires ecotoxicological impact assessment. River microbial communities serve as effective bioindicators for this purpose. We quantified the effects of eight commonly used ABXs on a freshwater river microbial community using Biolog EcoPlates™, enabling the assessment of growth and physiological profile changes. Microbial community characterization involved 16S rRNA gene sequencing. The river community structure was representative of aquatic ecosystems, with the prevalence of Cyanobacteria, Proteobacteria, Actinobacteria, and Bacteroidetes. Our findings reveal that all ABXs at 100 µg/mL reduced microbial community growth and metabolic capacity, particularly for polymers, carbohydrates, carboxylic, and ketonic acids. Chloramphenicol, erythromycin, and gentamicin exhibited the highest toxicity, with chloramphenicol notably impairing the metabolism of all studied metabolite groups. At lower concentrations (1 µg/mL), some ABXs slightly enhanced growth and the capacity to metabolize substrates, such as carbohydrates, carboxylic, and ketonic acids, and amines, except for amoxicillin, which decreased the metabolic capacity across all metabolites. We explored potential correlations between physicochemical parameters and drug mechanisms to understand drug bioavailability. Acute toxicity effects at the river-detected low concentrations (ng/L) are unlikely. However, they may disrupt microbial communities in aquatic ecosystems. The utilization of a wide array of genetically characterized microbial communities, as opposed to a single species, enables a better understanding of the impact of ABXs on complex river ecosystems.

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Occurrence, sources and environmental risk assessment of pharmaceuticals in the Sea of Marmara, Turkey

Cited by 24 publications

References 101 publications

Emerging Contaminants in the Effluent of Wastewater Should Be Regulated: Which and to What Extent?

Emerging Contaminants in the Effluent of Wastewater Should Be Regulated: Which and to What Extent?

Updated knowledge, partitioning and ecological risk of pharmaceuticals and personal care products in global aquatic environments

Assessing the Ecotoxicity of Eight Widely Used Antibiotics on River Microbial Communities

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