Occurrence ofCandida strains in cases of paronychia

Dorko, Erik; Jautová, J; Pilipčinec, E.; Tkáčiková, Ľudmila

doi:10.1007/bf02931539

Cited by 8 publications

(5 citation statements)

References 16 publications

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“…For example, biofilm production by Candida in wound healing promotes a chronic state of inflammation by creating a physical barrier and providing the wound with low oxygen and low pH, in turn delaying the wound-healing process ( 61 ). Candida can also lead to localized long-term inflammatory processes, such as vaginitis ( 62 ), stomatitis ( 63 ), and paronychia ( 64 ). Of particular relevance is that the yeast often colonizes and infects immunocompromised individuals.…”

Section: Discussionmentioning

confidence: 99%

Thrombin-Derived C-Terminal Peptide Reduces Candida -Induced Inflammation and Infection In Vitro and In Vivo

Dahlman

Puthia

Petrlová

et al. 2021

Antimicrob Agents Chemother

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Infections due to the opportunistic fungus Candida have been on the rise in the last decades, especially in immunocompromised individuals and hospital settings. Unfortunately, the treatments available today are limited. Thrombin-derived C-terminal peptide (TCP-25) is an antimicrobial peptide (AMP) with antibacterial and immunomodulatory effects. In this work, we, for the first time, demonstrate TCP-25’s ability to counteract Candida in vitro and in vivo . Using a combination of viable count assay, radial diffusion assay, fluorescence and transmission electron microscopy analyses, TCP-25 was found to exert a direct fungicidal activity. An inhibitory activity of TCP-25 on NF-κB activation induced by both zymosan alone and heat-killed C. albicans was demonstrated in vitro using THP-1 cells, and in vivo using NF-κB reporter mice. Moreover, the immunomodulatory property of TCP-25 was further substantiated in vitro by analyzing cytokine responses in human blood stimulated with zymosan, and in vivo employing a zymosan-induced peritonitis model in C57BL/6 mice. The therapeutic potential of TCP-25 was demonstrated in mice infected with luminescent C. albicans . Finally, the binding between TCP-25 and zymosan was investigated using circular dichroism spectroscopy and intrinsic fluorescence analysis. Taken together, our results show that TCP-25 has a dual function by inhibiting Candida as well as the associated zymosan-induced inflammation. The latter function is accompanied by a change in secondary structure upon binding to zymosan. TCP-25, therefore, shows promise as a novel drug candidate against Candida infections.

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Section: Discussionmentioning

confidence: 99%

Thrombin-Derived C-Terminal Peptide Reduces Candida -Induced Inflammation and Infection In Vitro and In Vivo

Dahlman

Puthia

Petrlová

et al. 2021

Antimicrob Agents Chemother

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“…Gram negative bacteria in patients with diabetes was also reported by several groups. These included E. coli 0.72-4.2% (19,25,26), Proteus (Proteus vulgaris in 4.2%) (12,19,25,26), Pseudomonas aeruginosa at rates of 1.3-7.2% (12,14,18,26,27), Klebsiella at rates of 3.5-7% (9,12,19,25,26,27), Enterobacter in 1.9-5.6% (9,12,19,28), and Aerobacter aerogens in 0.72% (14). Klebsiella was the most common Gram negative organism along with staphylococcus species in mixed infection by Jalil et al (20) (10).…”

Section: Discussionmentioning

confidence: 99%

“…Connor et al(28) reported the presence of Gram-negative organisms in 31% including Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, and species of Klebsiella, Serratia, Haemophilus, Enterobacter, Eikenella, Pasteurella, and Neiserria. Dorko et al(27) reported the presence Neisseria spp. Most authors report the role predominantly of S. aureus in hand infection but with different percentage(14,19,22,26,28).…”

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confidence: 99%

Clinical and microbiological characteristics of hand infection in female patients with Diabetes Attending University in Qassim, Saudi Arabia

Yacoubi

Al‐Shobaili

2014

Ibnosina Journal of Medicine and Biomedical Sciences

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Background: Hand infection in diabetics is a well-known problem which results in high morbidity and occasional mortality. Patients and methods: 182 cases of hand infection were collected from the Qassim University over the past two years. 114 diabetic female patients, of any type (1, 2), were included in this study. Clinical examination and culture were done. Different media were used for the isolation of aerobic, anaerobic and yeast. Results: E. coli was the most prevalent organism in diabetic patients. The isolates that were observed in decreasing order of frequency, in diabetic patients, were E. coli, S. aureus, Streptococcus beta hemolytic, Pseudomonas aeruginosa, Proteus sp., Streptococcus viridans, Enterobacter, anaerobes and yeast (Candida). In the control cases we found S.aureus in high percentage followed by Coagulase negative Staphylococcus, Enterococcus and E.coli, Streptococcus beta hemolytic, P. aeruginosa, anaerobes and in low percentage K. pneumonia and Enterobacter. Conclusions: This study demonstrates bacterial composition of diabetic's hand flora predominated by Gram negative organisms. The presence of anaerobes, and fungi is noted.

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“…Connor et al [11] reported Gram-bacteria in 31% including Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, Klebsiella, Serratia, Haemophilus, Enterobacter, Eichenella, Pasteurella and Neisseria. Dorko et al [12] reported Neisseria spp., Staphylococcus Coagulase negative between 5.7% and 12.6% (8); Streptococcus spp in 5.6-16% [2]. Staphylococcus β-haemolyticus were mostly S. pyogenes between 3.6 and 12.5% [2].…”

Section: Review Of the Literaturementioning

confidence: 99%

“…Staphylococcus β-haemolyticus were mostly S. pyogenes between 3.6 and 12.5% [2]. Dorko et al [12] reported streptococcus α-haemolyticus in 22.4%. Not-β-haemolyticus S.Viridians were found in 1.3% [7], 2.16% [7].…”

Section: Review Of the Literaturementioning

confidence: 99%

The Ischemic/Septic Diabetic Hand: Review of Literature and a Case Report

Crisci¹

2018

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The term "diabetic hand" was born to describe the complications of the diabetes mellitus on the hand resulting in a rigid hand with a poor mobility. The traumatic wounds with soft tissue involvement increase the risk of infection. Staphylococcus aureus methicillin-resistant (MRSA) is the most common bacterium isolated in the hand infections. The case report of a type 2 diabetic patient, dialysed with chronic obstructive peripheral artery disease and Monckeberg sclerosis of the vessels of the hands, ischemic necrosis of the right hand fingers is reported by the authors. In the diabetic patient the hands can be infected in the same way that feet could be infected too. Several amputation interventions have been performed with the intent of saving part of the hand. The diabetic hand syndrome (DHS) is an important pathology that requires strong antibiotics and surgery to avoid severe disability as rigidity, contracture and amputation. Apparently, in the last years good results are reported using antibiotic, surgical and hyperbaric treatment. In conclusion it would be wrong to ignore or underestimate this disease and any doctor should practice a scrupulous visit of the hands in the diabetic patient.

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Occurrence ofCandida strains in cases of paronychia

Cited by 8 publications

References 16 publications

Thrombin-Derived C-Terminal Peptide Reduces Candida -Induced Inflammation and Infection In Vitro and In Vivo

Thrombin-Derived C-Terminal Peptide Reduces Candida -Induced Inflammation and Infection In Vitro and In Vivo

Clinical and microbiological characteristics of hand infection in female patients with Diabetes Attending University in Qassim, Saudi Arabia

The Ischemic/Septic Diabetic Hand: Review of Literature and a Case Report

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