Occurrence of venlafaxine, other antidepressants and selected metabolites in the Rhine catchment in the face of climate change

Schlüsener, Michael P.; Hardenbicker, Paulin; Nilson, Enno; Schulz, Manoj; Viergutz, Carsten; Ternes, Thomas A.

doi:10.1016/j.envpol.2014.09.019

Cited by 105 publications

(52 citation statements)

References 40 publications

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“…VFX and their two metabolites also showed negative removals in both campaigns, with higher concentrations after MBR treatment. These results are in accordance with previous studies in which negative elimination rates were obtained after CAS treatment [31,32]. The limited sorption to the biomass of these compounds (low solid-water distribution coefficient (K d )) and their resilience to biodegradation could explain partly this poor removal.…”

Section: Removal Of Phacs By Mbrsupporting

confidence: 92%

Fate of pharmaceuticals and their transformation products in integrated membrane systems for wastewater reclamation

Mamo

García-Galán

Stefani

et al. 2018

Chemical Engineering Journal

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The removal of pharmaceuticals (PhACs) present in urban wastewater by membrane bioreactors (MBRs) followed by reverse osmosis (RO) or nanofiltration (NF) membranes has been frequently addressed in the literature. However, data regarding the removal of their main human metabolites and transformation products (TPs) is still scarce. In this study, the presence of 13 PhACs and 20 of their metabolites and TPs was monitored during 2 consecutive years in the different treatment steps of urban raw wastewater (sewer, primary treatment, MBR and RO/NF). Rejection of the selected contaminants when using low pressure NF membranes (NF-90) or RO membranes (ESPA 2) after the MBR step was also investigated. The analgesic acetaminophen, which was found at the highest concentrations in the sewer and influent samples (18–74 µg L-1) over the two experimental periods, was fully eliminated during MBR treatment. Those PhACs that were only partially removed after the MBR, were almost completely removed (>99%) by the RO membrane working under different process conditions. At a similar average permeate fluxes (18 L m-2 h-1), the NF membrane showed high removal efficiencies (>90%) for all of the PhACs and their metabolites, though lower than those achieved by the RO membrane. When the flux of the NF90 membrane was increased to 30 L m-2 h-1 (while still operating at a feed pressure lower than the RO membrane at 18 L m-2 h-1) the performance of the membrane increased, achieving 98% rejection of PhACs.Peer ReviewedPostprint (author's final draft

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Section: Removal Of Phacs By Mbrsupporting

confidence: 92%

Fate of pharmaceuticals and their transformation products in integrated membrane systems for wastewater reclamation

Mamo

García-Galán

Stefani

et al. 2018

Chemical Engineering Journal

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“…These values were mostly similar to the values previously reported for pharmaceuticals in river and sewage samples [48,51]. The vales of limit of detection (LOD) and limit of quantification (LOQ), which are important for estimating the sensitivity of the methods, were calculated based on the concentrations at signal-to-noise ratios of 3 and 10 [52,53]. The estimated LOD and LOQ values for liquid samples were in ranges of 0.1-0.4 and 0.3-1.4 ng/L, respectively, but the corresponding values for solid samples appeared in larger ranges of 2.4-13 and 8.2-42 ng/kg, respectively.…”

Section: Selection Of Anticancer Drugs and Their Quantificationsupporting

confidence: 81%

Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan

Azuma

2018

Applied Sciences

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This article reviews the pollution status of anticancer drugs present in the Yodo River basin located in the Kansai district of Japan, covering both the soluble and insoluble (adsorbed on the river sediments and suspended solids) levels. Procedures ranging from sampling in the field and instrumental analytical methods to the data processing for mass balance estimation of the target basin are also described. All anticancer drugs concerned with this article were detected in sewage and river waters, where the presence of bicalutamide (BLT) was identified at considerably high concentrations (maximum 254 ng/L in the main stream, 151 ng/L in tributaries, and 1032 ng/L in sewage treatment plant (STP) effluents). In addition, sorption distribution coefficient (logKd) values showed a tendency to become higher in the silty sediments at Suita Bridge than in the sandy sediments at Hirakata Bridge; these trends were supported by the results of the laboratory-scale sorption experiment. STPs were concluded to be the main sources of the anticancer drug load in the river, and a mass flux evaluation revealed that the effect of attenuation in the river environment was small. The effectiveness of ozonation in the sewage treatment process for removal of these anticancer drugs was further confirmed. The present article should be of value for facilitating the environmental risk assessment of a wide range of drugs in a broader geographical area.

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“…More typical loads are in the 10–150 ng/l range while the predicted concentration needed in surrounding water to reach human therapeutic levels in fish is 141 ng/l for citalopram (Fick et al 2010 ). Since there are several SSRIs in active use however, the total SSRI concentration may be much higher than the concentration of a single drug will show (Schlüsener et al 2015 ; Schultz et al 2010 ; Vasskog et al 2008 ). In addition, some of the SSRI metabolites retain some SSRI effect (Hiemke and Härtter 2000 ; Pawlowski et al 1985 ), adding to the total SSRI concentration.…”

Section: Introductionmentioning

confidence: 99%

Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus)

et al. 2017

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Selective Serotonin re-uptake inhibitors (SSRIs) are a class of psychotropic drugs used to treat depression in both adolescents and pregnant or breast-feeding mothers as well as in the general population. Recent research on rodents points to long-lasting behavioural effects of pre- and perinatal exposure to SSRIs which last into adulthood. In fish however, studies on effects of developmental exposure to SSRIs appears to be non-existent. In order to study effects of developmental SSRI exposure in fish, three-spine sticklebacks were exposed to 1.5 µg/l of the SSRI citalopram in the ambient water for 30 days, starting two days post-fertilisation. After approximately 100 days of remediation in clean water the fish were put through an extensive battery of behavioural tests. Feeding behaviour was tested as the number of bites against a piece of food and found to be increased in the exposed fish. Aggression levels were measured as the number of bites against a mirror image during 10 min and was also found to be significantly increased in the exposed fish. Novel tank behaviour and locomotor activity was tested in an aquarium that had a horizontal line drawn half-way between the bottom and the surface. Neither the latency to the first transition to the upper half, nor the number of transitions or the total time spent in the upper half was affected by treatment. Locomotor activity was significantly reduced in the exposed fish. The light/dark preference was tested in an aquarium where the bottom and walls were black on one side and white on the other. The number of transitions to the white side was significantly reduced in the exposed fish but there was no effect on the latency to the first transition or the total time spent in the white half. The results in the current study indicate that developmental SSRI exposure causes long-lasting behavioural effects in fish and contribute to the existing knowledge about SSRIs as environmental pollutants.

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Occurrence of venlafaxine, other antidepressants and selected metabolites in the Rhine catchment in the face of climate change

Cited by 105 publications

References 40 publications

Fate of pharmaceuticals and their transformation products in integrated membrane systems for wastewater reclamation

Fate of pharmaceuticals and their transformation products in integrated membrane systems for wastewater reclamation

Distribution of Anticancer Drugs in River Waters and Sediments of the Yodo River Basin, Japan

Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus)

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