Occurrence of the Uric Acid Stone in Newborn Piglets

Kakino, Jun; Kodaka, T; Sato, Ryo; Naito, Yoshihisa

doi:10.12935/jvma1951.50.69

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“…It was shown that uric acid urolithiasis was frequently detected in newborn piglets with low body weight during the two weeks after the birth [9]. It was postulated that newborn piglets with low body weights have non-nutrition and unusual activities of enzymes factors.…”

Section: Discussionmentioning

confidence: 99%

“…It was suspected that the plasma uric acid levels (0.8 ± 0.20 mg/dl) [9] in newborn piglets with a uricase is considerably lower than those (5.5 ± 2.2 mg/dl) [12] in human neonates without a uricase. Allopurinol is an inhibitor of xanthine oxidase.…”

Section: Discussionmentioning

confidence: 99%

“…Although these studies have suggested, as predisposing factors for this disease, viral infection [6], a low level of uricase activity in the liver [7,11], colds [7], starvation [11] and an excess of purine metabolism [8], the determinable etiology has not been demonstrated. We previously investigated the incidence of the uric acid stones in the kidneys of the newborn piglets at necropsy [9], and found that 108 of 1,338 piglets died within 18 days of age and uric acid stones were present in 13.0% of the dead piglets mostly with low body weight.…”

mentioning

confidence: 99%

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Purine Metabolism of Uric Acid Urolithiasis Induced in Newborn Piglets.

Kakino

Sato

Naito

1998

The Journal of Veterinary Medical Science

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ABSTRACT. To clarify the relationship between uric acid urolithiasis and purine catabolites in newborn piglets, the incidence of uric acid urolithiasis and the plasma concentrations of xanthine, hypoxanthine, uric acid and allantoin were examined in 32 piglets. The newborn piglets were divided into two groups: normal (over 1.2 kg, n=18, group N) and low body weight (below 0.9 kg, n=14, group L). The animals in both groups were given water (non-nutrition, n=11, treatment W), artificial milk (normal nutrition, n=12, treatment M), or a combination of water and allopurinol (prophylactic treatment for the urolithiasis, n=9, treatment A), during the first 60-hr of birth. At necropsy, the incidence of urolithiasis was higher in the piglets that received treatment W than those in the treatment M or A in both the N and L groups. In group L, the plasma xanthine, hypoxanthine and uric acid concentrations were markedly increased in the piglets that underwent treatment W compared with the treatment M. In both the N and L groups, the plasma allantoin concentration was higher in the treatment W piglets as compared with the treatment M piglets. These results suggested that the occurrence of uric acid urolithiasis in the newborn piglets is attributable to increased purine catabolites due to a starvational condition after birth. -KEY WORDS: purine catabolite, swine (newborn), uric acid urolithiasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%