Occurrence of the parathyroid cyst in golden hamsters

Chen, Huayue; Hayakawa, Daisuke; Emura, S.; Ozawa, Yuki; Taguchi, Hirotaka; Yano, Ryuichiro; Shoumura, Shízuko

doi:10.1016/s0940-9602(00)80087-4

Cited by 5 publications

(3 citation statements)

References 15 publications

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“…Mitosis is seldom found in normal adult animals. Recently we found there were some mitoses and apoptosis in the walls of chief cell cyst in fiveday-old hamster parathyroid gland, indicating the rapid proliferation of the chief cells at this age (Chen et aL, 2000). In the present study, chief cells undergoing mitotic division were regularly present in the rats fed with the low calcium diet.…”

Section: Discussionsupporting

confidence: 66%

Effect of Low Calcium Diet on the Ultrastructure of the Rat Parathyroid Gland

Chen

Hayakawa

Emura

et al. 2001

Okajimas Folia Anatomica Japonica

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Summary: Young female rats were fed with normal (1.18%) or low (0.05%) calcium diet for 3, 7, 15 or 30 days. The morphology of the parathyroid glands was studied together with serum calcium, parathyroid hormone (PTH), calcitonin and bone mineral density (BMD). As compared to the animals fed with the normal calcium diet, BMD of whole body of the rats fed with the low calcium diet was significantly decreased, whereas the serum PTH level was increased. The parathyroid glands in the rats fed with the low calcium diet were markedly enlarged. In the parathyroid chief cells of the rats fed with the low calcium diet, the Golgi complexes and the cisternae of the granular endoplasmic reticulum were well developed, while the large granules and large vacuolar bodies decreased. Some secretory granules located near the plasma membrane. A proportionally larger increase of the cytoplasm was estimated in the rats fed with the low calcium diet for three and seven days. Enlargement of the cytoplasm and rather frequent mitoses of the chief cells were observed in the rats fed with the low calcium diet for 15 and 30 days. These findings suggest that the rapid bone loss in young rats induced by the low calcium diet is essentially due to stimulated activity of the parathyroid gland. The stimulated gland may be a result of hypertrophy at the early stage and a combination of hypertrophy and hyperplasia at the later stage of calcium deficiency.

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Section: Discussionsupporting

confidence: 66%

Effect of Low Calcium Diet on the Ultrastructure of the Rat Parathyroid Gland

Chen

Hayakawa

Emura

et al. 2001

Okajimas Folia Anatomica Japonica

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“…Some ciliated cysts are observed in young hamsters [18]. The frequency of parathyroid cysts decreases with aging.…”

Section: Gross Anatomy Of the Parathyroid Glandmentioning

confidence: 91%

“…The frequency of parathyroid cysts decreases with aging. The cyst possesses the features of the pharyngeal epithelia and may arise from embryological remnants of pharyngeal pouches undergoing cystic degeneration and entrapping portions of parathyroid tissue [18]. The parathyroid follicles sometimes occur in various species of animals.…”

Section: Gross Anatomy Of the Parathyroid Glandmentioning

confidence: 99%

An Update on the Structure of the Parathyroid Gland

Chen¹,

Senda²,

Emura³

et al. 2013

Open Anat J

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Abstract:The parathyroid glands hold a special place in human anatomy, since they were the last major organ to be recognized by humans. The glands are recognized in all vertebrate animals higher than fish, and are derived from the pharyngeal pouches. The molecular signaling pathways that are involved in determining the differentiation of the glands are being elucidated. Studies in mice have demonstrated that the transcription factor encoded by Glial cells missing 2 (Gcm2) is a key regulator of parathyroid development. Recent studies indicate that the tetrapod parathyroid glands and the gills of fish are evolutionarily related structures, and that the parathyroid glands likely come into being as a result of the transformation of the gills during tetrapod evolution. The parathyroid chief cells play a central role in calcium homeostasis by sensing changes in extracellular calcium and releasing parathyroid hormone (PTH) to correct or maintain normal blood calcium levels. Chief cells undergo morphologic changes corresponding to different stages of the secretory cycle. Parathyroid oxyphil cells derived from chief cells as aging or some metabolic derangements, have the potential to produce PTH, PTH-related protein, and calcitriol. The existence of water-clear cells is confirmed in some kinds of animals, which may represent hyperfunction of the parathyroid gland. The presence of water-clear cell is associated with parathyroid hyperplasia or parathyroid adenoma. The molecular regulation of PTH synthesis and release indicates that parathyroid cells detect changes of the extracellular calcium levels by calcium-sensing receptor, which plays a central role in regulating PTH secretion.

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Hamsters

2017

Pathology of Small Mammal Pets

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Occurrence of the parathyroid cyst in golden hamsters

Cited by 5 publications

References 15 publications

Effect of Low Calcium Diet on the Ultrastructure of the Rat Parathyroid Gland

Effect of Low Calcium Diet on the Ultrastructure of the Rat Parathyroid Gland

An Update on the Structure of the Parathyroid Gland

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