Occurrence of the “applause sign” in patients with amyotrophic lateral sclerosis

Anneser, Johanna; Krzovska, Marija; Borasio, Gian Domenico; Danek, Adrian

doi:10.1016/j.clineuro.2015.06.005

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…a tendency to clap more than three times in response to the demonstration of clapping only three times) was present in various neurodegenerative diseases, such as PSP, Parkinson’s disease, corticobasal syndrome, multisystem atrophy, cortical dementias (e.g. AD and behavioural variant of frontotemporal dementia), and amyotrophic lateral sclerosis . AS is considered a consequence of perseveration due to frontal lobe impairment, a part of dysexecutive syndrome .…”

Section: Introductionmentioning

confidence: 99%

Triple test, a diagnostic observation, can detect cognitive impairment in older adults

et al. 2018

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The present study suggests that the triple test is a simple, quick, and efficient screening tool for detecting cognitive impairment, and the results may reflect deterioration in patients' activities of daily living. Additionally, it could be advantageous in clinical practice because educational level does not affect the test outcome. Therefore, it may be an appropriate test to screen for cognitive impairment in the elderly, both as a bedside diagnostic test and in daily clinical practice, especially in the primary care setting.

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Section: Introductionmentioning

confidence: 99%

Triple test, a diagnostic observation, can detect cognitive impairment in older adults

et al. 2018

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The applause sign in frontotemporal lobar degeneration and related conditions

et al. 2018

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Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity

McCombe

Wray

Henderson

2017

Expert Review of Neurotherapeutics

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease defined by the presence of muscle weakness. The motor features of disease are heterogeneous in site of onset and progression. There are also extra-motor features in some patients. The genetic basis for extra-motor features is uncertain. The heterogeneity of ALS is an issue for clinical trials. Areas covered: This paper reviews the range and prevalence of extra-motor features associated with ALS, and highlights the current information about genetic associations with extra-motor features. Expert commentary: There are extra-motor features of ALS, but these are not found in all patients. The most common is cognitive abnormality. More data is required to ascertain whether extra-motor features arise with progression of disease. Extra-motor features are reported in patients with a range of causative genetic mutations, but are not found in all patients with these mutations. Further studies are required of the heterogeneity of ALS, and genotype/phenotype correlations are required, taking note of extra-motor features.

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Occurrence of the “applause sign” in patients with amyotrophic lateral sclerosis

Cited by 4 publications

References 20 publications

Triple test, a diagnostic observation, can detect cognitive impairment in older adults

Triple test, a diagnostic observation, can detect cognitive impairment in older adults

The applause sign in frontotemporal lobar degeneration and related conditions

Extra-motor abnormalities in amyotrophic lateral sclerosis: another layer of heterogeneity

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