Occurrence of Sperm Antibodies in Adult Rats after Prefertile Traumatic vas Lesions

Pedersen, Jörgen; Rubenson, A.; Nilsson, Lars‐Åke

doi:10.3109/00365598709180280

Cited by 18 publications

(3 citation statements)

References 15 publications

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“…The operative field remains hazardous despite measures that are claimed to reduce the inflammatory response (Corkery, 1975). The vas and testicular vessels may be visibly or covertly damaged, only to present later as gonadal atrophy or infertility (Janik and Shandling, 1982;Pedersen et al, 1987;Parkhouse and Hendry, 1991).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Two‐stage Orchiopexy on Testicular Growth

Corbally

Quinn

Guiney

1993

British Journal of Urology

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Testicular growth was measured in 33 males who had undergone 2 orchiopexies on the developing testis. Multiple surgery on the abdominal or canalicular testis was associated with a high rate of testicular atrophy (40%) and a 46% decrease in testicular volume. A similar decrease (43%) in testicular volume was noted in those patients with an infracanalicular testis but no testis atrophied in this group. The results suggest that primary orchiectomy be considered in the high testis provided the contralateral testis is normal, or alternatively a Fowler-Stephens or microvascular transplant if it is not. Patients with an infracanalicular testis may undergo a careful second-stage orchiopexy. All patients with retarded testicular growth should perform routine self-examination.

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Section: Discussionmentioning

confidence: 99%

The Effect of Two‐stage Orchiopexy on Testicular Growth

Corbally

Quinn

Guiney

1993

British Journal of Urology

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“…The effect of contralateral testicular damage after unilateral vas ligation has been demonstrated to be mediated through antisperm autoantibodies in several studies (Haas, 1987;Pedersen et al, 1987;Flickinger et al, 1988;Chehval et al, 1995). It has been reported that early repair of the severed vas, before the development of antisperm autoantibodies, will avoid potential damage to the contralateral testicle (Flickinger et al, 2000).…”

mentioning

confidence: 99%

Antisperm Autoantibody Response After Unilateral Vas Deferens Ligation in Rats: When Does it Develop?

CHEHVAL,

DOSHI,

KIDD

et al. 2002

Journal of Andrology

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Unilateral obstruction or injury to the vas deferens can result in significant injury to the contralateral testicle. Antisperm autoantibodies are thought to play a significant role in this phenomenon. It has been reported that early surgical repair of the vas, before the development of antisperm autoantibodies, will prevent any potential damage to the contralateral testicle. This led us to investigate the timing of the antisperm antibody production and to attempt to determine whether antibody production precedes histologic testicular damage in the Lewis rat model. In a controlled study, mature rats were divided into temporal groups, with the experimental animals all receiving a unilateral vasectomy. At postoperative endpoints of 1, 7, 15, or 30 days, blood samples were collected for immunologic assay, and the testicles were harvested for histologic examination. Antibody levels were measured by an immunobead test using goat anti‐rat immunoglobulin G (IgG)‐coated Sepharose beads; tissue sections were fixed in Bouin solution, embedded in paraffin, and stained with hematoxylin and eosin. There was no statistically significant histologic difference between any of the groups. However, immunologic evaluation revealed a statistically significant increase in immunobead antibody binding in the 30‐day group compared to the control groups (P = .02). These data seem to indicate that in this model, antisperm antibody production is not evident until 15–30 days after unilateral injury to the vas deferens occurs, and the development of these antibodies precedes any demonstrable histologic damage to the testicle. If it is correct to infer that human antisperm antibody production will also precede histologic testicular damage, and further, that the onset of the human autoantibody response may vary from several days to weeks, then in cases of suspected or known ductal injury, the clinical monitoring of antisperm antibody levels could enable testicular damage to be predicted prior to its development and thus be avoided.

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“…There is some evidence that experimental injury to the vas deferens before puberty in rats is Read at the 46th Annual Meeting of the British Association of Urological Surgeons in Scarborough, July 1990 associated with later production of antibodies to spermatozoa and that early vasal reconstruction prevents this phenomenon (Pederson et al, 1987). However, there have been no detailed studies in humans to ascertain whether vasal injuries in childhood are of relevance to later fertility.…”

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confidence: 99%

Vasal Injuries during Childhood and their Effect on Subsequent Fertility

Parkhouse

Hendry

1991

British Journal of Urology

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Thirty subfertile males had testicular obstruction following inguinal or pelvic surgery in childhood. All 13 patients with bilateral obstruction were azoospermic and 6 had developed antibodies to spermatozoa. Of 17 patients with unilateral obstruction, 11 had oligozoospermia and 6 had normal sperm counts: all had high titres of antibodies to spermatozoa (a significant difference from the men with bilateral obstruction). This indicates that male infertility can result from vasal or epididymal injuries in childhood due either to the obstruction itself or its immunological consequences. Following corrective surgery and prednisolone treatment for the antibodies, where appropriate, 5/17 patients with unilateral blocks and 1/11 with bilateral blocks successfully produced pregnancies.

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Occurrence of Sperm Antibodies in Adult Rats after Prefertile Traumatic vas Lesions

Cited by 18 publications

References 15 publications

The Effect of Two‐stage Orchiopexy on Testicular Growth

The Effect of Two‐stage Orchiopexy on Testicular Growth

Antisperm Autoantibody Response After Unilateral Vas Deferens Ligation in Rats: When Does it Develop?

Vasal Injuries during Childhood and their Effect on Subsequent Fertility

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