Occurrence of Recurrent Aphthous Stomatitis (RAS) as a Rare Oral Manifestation in a Patient with Gilbert’s Syndrome

Abstract

Recurrent aphthous stomatitis is an ulcerative disease of the oral cavity and can occur in isolation or as a manifestation of many systemic diseases. It is a quite common entity and may hence often be overlooked as an isolated lesion. Gilbert’s syndrome is a genetic disorder where a deficiency of an enzyme associated with the conjugation of bilirubin results in unconjugated hyperbilirubinemia. The disease is generally asymptomatic and is aggravated by certain trigger factors. No associated oral manifestations are known. In this case report, we discuss the concomitant presence of recurrent aphthous stomatitis in a patient of Gilbert’s syndrome. The presence of such recurrent stomatitis may represent as an oral manifestation of Gilbert’s syndrome. Early identification of these entities may improve the overall quality of life of the patient.

The Cytotoxicity and Anticancer Effects of Propolis against the Oral Squamous Cell Carcinoma: In Vitro Study

“…Today's biomedical applications of natural products cover a broad spectrum of diseases that can be treated with them [31]. The ninth most prevalent type of malignancy is head and neck cancer worldwide, with a high mortality rate in developing countries [32], [33], [34], [35]. These tumors behave aggressively and can cause harmful diseases and form early local lymphoma and distant metastasis in the future [32], [36].…”

Clinical relevance of the use of Dentoxol® for oral mucositis induced by radiotherapy: A phase II clinical trial

“…Although these results may seem similar, notably, KGF is a drug with important limitations: it is not indicated for solid tumors because it may enhance their growth; the cost is much higher; and it must be administered by IV infusion. Other products used for similar clinical conditions could be considered for comparative evaluations[ 27 ].…”

Current Infections of the Orofacial Region: Treatment, Diagnosis, and Epidemiology

“…Some of them can even be life-threatening. The local and systemic factors determining the microbiota and genetics, as well as the individual factors such as diet, teeth brushing habits, dentures, dental procedures, mouthwashes, medications, etc., can be involved in the occurrence of orofacial infections [ 1 , 3 , 4 , 5 , 6 , 7 ]. Oral infections can occur under certain conditions, such as poor oral hygiene, antibiotic consumption, trauma, and dry mouth, and can damage the oral cavity.…”