Occurrence of prolactinoma after estrogen treatment in a girl with constitutional tall stature

Panteón, E; Loumaye, Ernest; Moes, Maaike I; Malvaux, P

doi:10.1016/s0022-3476(88)80279-8

Cited by 22 publications

(10 citation statements)

References 9 publications

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“…In most studies, unwanted side effects have been reported only during treatment or shortly after discontinuation of therapy (109,112,113,127,128,130,131,183,189,196,197). Most side effects were found to be mild and reversible (see Table 9).…”

Section: Other Adverse Effectsmentioning

confidence: 99%

Sex Steroid Treatment of Constitutionally Tall Stature*

1998

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Section: Other Adverse Effectsmentioning

confidence: 99%

Sex Steroid Treatment of Constitutionally Tall Stature*

1998

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“…So far, unwanted side effects have only been reported during treatment or shortly after its discontinuation.1-10 [17][18][19][20][21] Most side effects were found to be mild and reversible.…”

mentioning

confidence: 99%

Long term sequelae of sex steroid treatment in the management of constitutionally tall stature.

Waal

Torn

Keizer‐Schrama

et al. 1995

Archives of Disease in Childhood

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Aim-To evaluate possible long term side effects of high doses of sex steroids in the management of constitutionally tall stature, with special attention to hypothalamic-gonadal function.Methods-Sixty four tall adult men and 180 tall adult women, who received supraphysiological doses of sex hormones during puberty, were interviewed in a standardised way at a mean follow up period of 10 years after cessation of treatment. Sixty one untreated tall adult men and 94 untreated tall adult women served as controls. Results-The majority of the subjects were satisfied with their decision regarding hormone treatment. Seventy seven per cent of the women and 78% of the men reported one or more side effects during treatment. Most side effects were mild. In women, only 3% stopped treatment because of an adverse event; in men, the reported side effects never stopped treatment. The frequency of reported side effects in women was higher during treatment with high doses of oestrogens than during oral contraceptive use, indicating a dose dependent relationship. Amenorrhoea of longer than six months after cessation of therapy was found in 5%. Menstrual cycle characteristics of previously treated women were comparable with controls. Malignancy was not reported. Information about a total of 127 pregnancies was obtained and revealed no distinct differences in details and outcome between previously treated women and men, and controls. Conclusions-At a mean follow up of 10 years there is no evidence that pharmacological doses of sex hormones have a long term effect on reproductive function. However, this period is still too short to draw definite conclusions. (Arch Dis Child 1995; 73: 311-315)

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“…17 There is one report of a girl with a prolactinoma after high-dose estrogen treatment, but it is unclear whether this was a preexisting condition. 18 Recently, concerns about long-term effects on fertility in treated girls have been raised, 19 but clearly this is not relevant to our population.…”

Section: The Risks Of Treatmentmentioning

confidence: 99%

Attenuating Growth in Children With Profound Developmental Disability

Gunther

Diekema

2006

Arch Pediatr Adolesc Med

121

106

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Caring for children with profound developmental disabilities can be difficult and demanding. For nonambulatory children with severe, combined neurologic and cognitive impairment, all the necessities of life must be provided by caregivers, usually parents, and these tasks become more difficult as the child grows to adolescence and adulthood. Many parents would like to continue caring for their child with special needs at home but find it difficult to do so as the child increases in size. If growth could be permanently arrested while the child was still small, both child and parent would likely benefit because this would facilitate the option of continued care in the home. Treatment of the child with high-dose estrogen, initiated at an early age, could provide this option. High-dose estrogen both inhibits growth and rapidly advances maturation of the epiphyseal growth plates, bringing about permanent attenuation in size after a relatively short period of treatment. We present a case report and discuss the medical and ethical considerations of such an intervention strategy. We suggest that after proper screening and informed consent, growth-attenuation therapy should be a therapeutic option available to these children should their parents request it.

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Occurrence of prolactinoma after estrogen treatment in a girl with constitutional tall stature

Cited by 22 publications

References 9 publications

Sex Steroid Treatment of Constitutionally Tall Stature*

Sex Steroid Treatment of Constitutionally Tall Stature*

Long term sequelae of sex steroid treatment in the management of constitutionally tall stature.

Attenuating Growth in Children With Profound Developmental Disability

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