Occurrence of Occult Malignancies in Reduction Mammoplasties

Waldner, Matthias; Klein, Holger Jan; Künzi, W.; Guggenheim, Merlin; Plock, Jan A.; Giovanoli, Pietro

doi:10.3389/fsurg.2018.00017

Cited by 8 publications

(10 citation statements)

References 34 publications

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“…The cancer rate in patients with no history of breast cancer in previous studies ranged from 0 to 1% 12–26 . Similar to those studies, the cancer rate in our study was 0.36%.…”

Section: Discussionsupporting

confidence: 89%

“…In our study, the rate of AMBL in patients with no history of breast cancer was 3.3%. The previous studies that included only patients with no history of breast cancer reported the rate of AMBL to be between 1.5 and 14% 5,7–26 . The wide range of reported rates of AMBL in different studies can be attributed to different pathological assessment methods of RM specimens between institutions.…”

Section: Discussionmentioning

confidence: 98%

“…In this context, previous studies that analysed RM specimens showed a higher rate of incidental breast cancer in patients with a history of breast cancer compared to patients with no history of breast cancer 5–11 . The rate of incidental atypical and malignant breast lesions (AMBL) in patients with no history of breast cancer ranged from 1.5 to 14% 5,7–26 . One of the most common findings in all these studies was the older age of patients with AMBL compared to patients with no AMBL.…”

Section: Introductionmentioning

confidence: 89%

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The rate of incidental atypical and malignant breast lesions in reduction mammoplasty specimens

et al. 2020

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Aims: Reduction mammoplasty (RM) is one of the most common plastic surgeries in the United States. We aimed to demonstrate the rate of incidental atypical and malignant breast lesions (AMBL) found in RM specimens and the impact of the number of submitted tissue sections on the rate of AMBL. Methods and results: We analysed our database for patients who had undergone reduction mammoplasty between 2000 and 2018. Patients with a history of breast cancer were excluded from the study. All pathology reports were analysed for AMBL (ALH, LCIS, FEA, ADH, DCIS, invasive carcinoma). The grossing protocol was to submit 10 sections from each breast between 2000 and 2013 and six sections between 2014 and 2018. One hundred and sixtynine of 5208 patients (3.3%) and 216 of 10 340 RM specimens (2.1%) showed at least one AMBL. Nineteen (0.36%) patients had incidental cancer. The median age of patients with AMBL was significantly higher than patients without ABL (aged 59 years versus 45 years). There was no cancer in patients aged <30 years. The age-controlled rate of overall AMBL as well as atypia and cancer only did not decrease by submitting fewer sections during the 2014-18 period compared to the 2010-13 period. Conclusions: Decreasing the number of tissue sections from 10 to six did not lead to a significant decrease in the rate of overall AMBL or cancer. Our data suggest that submitting six tissue sections from each breast for patients aged >30 years and two sections from each breast for patients aged <30 years would be sufficient.

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“…The cancer rate in patients with no history of breast cancer in previous studies ranged from 0 to 1% 12–26 . Similar to those studies, the cancer rate in our study was 0.36%.…”

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 89%

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The rate of incidental atypical and malignant breast lesions in reduction mammoplasty specimens

et al. 2020

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“…Our study of 5781 women represents a large cohort of patients who underwent reduction mammaplasty. The rate of incidentally found breast cancer was consistent with that reported in prior literature (0.06-4.5%) [7,8,11,12].…”

Section: Discussionsupporting

confidence: 90%

“…However, breast cancer is the most common malignant cancer in women [2] and the presence of occult breast cancer in RM specimens has been described before [7,8,11,12]. In previous reports of reduction mammoplasty, the presence of a contralateral breast cancer was found to be a major risk factor for the presence of occult carcinoma [12][13][14]. Preoperative radiologic evaluation is an important tool to reduce the number of carcinomas detected by chance during RM.…”

Section: Discussionmentioning

confidence: 99%

Occult Pathologic Findings in Reduction Mammaplasty in 5781 Patients—An International Multicenter Study

Kuehlmann

Vogl

Kempný

et al. 2020

JCM

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Breast cancer is among the most commonly diagnosed cancers in the world, affecting one in eight women in their lifetimes. The disease places a substantial burden on healthcare systems in developed countries and often requires surgical correction. In spite of this, much of the breast cancer pathophysiology remains unknown, allowing for the cancer to develop to later stages prior to detection. Many women undergo reduction mammaplasties (RM) to adjust breast size, with over 500,000 operations being performed annually. Tissue samples from such procedures have drawn interest recently, with studies attempting to garner a better understanding of breast cancer’s development. A number of samples have revealed nascent cancer developments that were previously undetected and unexpected. Investigating these so-called “occult” findings of cancer in otherwise healthy patients may provide further insight regarding risk factors and countermeasures. Here, we detail occult findings of cancer in reduction mammaplasty samples provided from a cohort of over 5000 patients from 16 different institutions in Europe. Although the majority of our resected breast tissue specimens were benign, our findings indicate that there is a continued need for histopathological examination. As a result, our study suggests that preoperative imaging should be routinely performed in patients scheduled for RM, especially those with risk factors of breast cancer, to identify and enable a primary oncologic approach.

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Surgical treatment trends and identification of primary breast tumors after surgery in occult breast cancer: a study based on the Japanese National Clinical Database—Breast Cancer Registry

et al. 2022

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Occurrence of Occult Malignancies in Reduction Mammoplasties

Cited by 8 publications

References 34 publications

The rate of incidental atypical and malignant breast lesions in reduction mammoplasty specimens

The rate of incidental atypical and malignant breast lesions in reduction mammoplasty specimens

Occult Pathologic Findings in Reduction Mammaplasty in 5781 Patients—An International Multicenter Study

Surgical treatment trends and identification of primary breast tumors after surgery in occult breast cancer: a study based on the Japanese National Clinical Database—Breast Cancer Registry

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