Occurrence of moniliformin in cereals

Radić, Danka; Kos, Jovana; Kocic-Tanackov, D Suncica; Hajnal, Elizabet Janić; Mandić, Ivana

doi:10.5937/ffr1902149r

Cited by 6 publications

(4 citation statements)

References 62 publications

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“…The results from this study, as well as previous studies from Serbia, are in agreement with previous studies on the widespread occurrence of MON worldwide. Many European countries have reported the presence of MON in cereals, with maize being the most frequently affected crop as per the available published data [14,23,24]. On the other hand, the fact that the level of maize contamination with MON is likely dependent on weather conditions during the maize growing season was highlighted by several authors.…”

Section: Comparative Studymentioning

confidence: 99%

“…The European Food Safety Authority (EFSA) recognized this problem and has started to publish reports to carry out a risk assessment for these toxins. However, the evidence of their occurrence is increasing, and they have become a target of the scientific community's research due to their widespread presence in food and feed, particularly in cereals and cereal-based products [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability

Radić,

Radović,

Janić Hajnal

et al. 2023

Toxins

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Moniliformin (MON) represents one of the most widespread emerging mycotoxins, whose presence in food and feed can potentially cause harmful effects on the health of both the public and animals. In order to investigate MON occurrence, a total of four hundred (n = 400) samples of unprocessed maize were sampled from different regions (Bačka, Banat, and Srem) of Serbia during a period of four years (2018–2021) and were analyzed using a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. The influence of regional differences and variations from year to year in terms of weather conditions on the occurrence of MON was also assessed. The obtained validation parameters indicated that the LC-MS/MS method is applicable to the determination of MON in maize samples. It can be observed from the acquired findings that all samples were contaminated with MON, while concentration levels varied between the samples, especially from different sampling years. The maize samples showed the greatest levels of MON concentration during the dry and hot climatic conditions experienced in 2021. In maize samples harvested in the period 2018–2020, the MON concentration levels detected were about two to three times lower compared to the year 2021. Additionally, a comprehensive investigation into the correlation between weather conditions and the occurrence of MON in maize grown in Serbia was undertaken by reviewing the outcomes of research undertaken in the past decade.

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Section: Comparative Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability

Radić,

Radović,

Janić Hajnal

et al. 2023

Toxins

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“…It inhibits oxidation of the tricarboxylic acid intermediate α-ketoglutarate and pyruvate dehydrogenase by interrupting pyruvate incorporation into the tricarboxylic acid cycle [16]. MON is known to be a natural contaminant in cereals worldwide [17]. In addition, the cooccurrence of mycotoxins in food and feed represents a natural trend, and the effects of mixtures of mycotoxins in feed on farm animals are yet to be fully understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of Abiotic Conditions on Growth, Mycotoxin Production, and Gene Expression by Fusarium fujikuroi Species Complex Strains from Maize

Dong

Qiao

et al. 2023

Toxins

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Fusarium fujikuroi species complex (FFSC) strains are a major concern for food quantity and quality due to their strong ability to synthesize mycotoxins. The effects of interacting conditions of water activity, temperature, and incubation time on the growth rate, toxin production, and expression level of biosynthetic genes were examined. High temperature and water availability increased fungal growth. Higher water activity was in favor of toxin accumulation. The maximum amounts of fusaric acid (FA) and fumonisin B1 (FB1) were usually observed at 20–25 °C. F. andiyazi could produce a higher content of moniliformin (MON) in the cool environment than F. fujikuroi. The expression profile of biosynthetic genes under environmental conditions varied wildly; it was suggested that these genes might be expressed in a strain-dependent manner. FB1 concentration was positively related to the expression of FUM1, while a similar correlation of FUB8 and FUB12 with FA production could be observed in F. andiyazi, F. fujikuroi, and F. subglutinans. This study provides useful information in the monitoring and prevention of such toxins entering the maize production chain.

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“…Moniliformin (MON) is a mycotoxin produced by Fusarium (F.) species, mainly F. proliferatum, F. avenaceum, F. subglutinans, and F. verticilloides (Peltonen et al, 2010). MON is frequently detected in cereal crops such as wheat, barley, oats, triticale, rice, and rye, while the highest contamination was detected in maize samples (Radić et al, 2019). MON is the most prevalent mycotoxin in cereals, which is confirmed in one of the most comprehensive available worldwide investigations of the occurrence of mycotoxins in cereals, conducted every year by BIOMIN Company (www.biomin.net, Biomin Report, 2016.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an HPLC–DAD method for the determination of moniliformin in maize

Radić

Hajnal

Mandić

et al. 2021

Food Processing Preservation

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Moniliformin (MON) is a polyketide mycotoxin with low molecular weight, which in nature generally occurs as a sodium or potassium salt. It is frequently detected in cereals, while the highest contamination was detected in maize. The aim of this study was to develop and validate an HPLC-DAD method for the detection of MON in maize.Extraction with the mixture of acetonitrile:water (84:16, vol/vol) without clean-up protocols provided the best MON recoveries. The mobile phase was acetonitrile/ water (12.5:87.5, vol/vol) or acetonitrile:water with ion-pair reagent (12.5:87.5, vol/ vol) using an isocratic method, while MON was evaluated by the HPLC column (C18, 4.6 x 250mm, 5 µm). The developed method was validated and provided satisfactory quantitative performance in terms of limit of detection (41 μg/kg), limit of quantification (125 μg/kg), linearity (125-2,000 μg/kg), repeatability (3%-7%), reproducibility (7%-15%), and recovery (83%-95%). Thus, the developed and validated method is suitable for the determination of MON in maize. Novelty impact statement:In this work, a new HPLC-DAD method was developed and validated for the determination of MON in maize samples. Since there are only a few developed HPLC-DAD methods for the determination of MON so far, the obtained results may contribute to the increase in knowledge in the field of analytical methods for its determination.

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Occurrence of moniliformin in cereals

Cited by 6 publications

References 62 publications

Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability

Moniliformin Occurrence in Serbian Maize over Four Years: Understanding Weather-Dependent Variability

Effect of Abiotic Conditions on Growth, Mycotoxin Production, and Gene Expression by Fusarium fujikuroi Species Complex Strains from Maize

Development and validation of an HPLC–DAD method for the determination of moniliformin in maize

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