Occurrence of menstrual cycle related seizure patterns among epileptic women attending the tertiary neurology clinics of the National Hospital of Sri Lanka

Kariyawasam, S. H.; Mannapperuma, Uthpali; Jayasuriya, W.J.A.B.N.; Weerathunga, J.; Munasinghe, K.

doi:10.1016/j.eplepsyres.2009.01.014

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…Studies relating estrogen serum levels and spells provided evidence that this facilitates seizure activity. 7 Administration of estrogen to women with epilepsy has been studied and some researchers found EEG changes in four of 16 individuals. 8 The pro-epileptic changes involving the altered GABA-receptor and that are likely to be relevant to catamenial epilepsy.…”

Section: Discussionmentioning

confidence: 99%

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Catamenial-sleep epilepsy: A case report

Poblano

Haro

Angel-Alavez

2013

Sleep and Biological Rhythms

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Our objective was to report the co‐occurrence of seizures during sleep and epilepsy during the menstrual period in a patient. We observed a 22‐year‐old woman with seizures during sleep; the seizures were related to menstruation. The episodes were of partial onset and secondarily generalized. She was under drug control. The patient's neurological examination and magnetic resonance imaging (MRI) were normal. Hormonal determination was within normal range for progesterone and estrogens. The polysomongraphy‐electroencephalogram (PSG‐EEG) disclosed discharges in the left fronto‐temporal area. Based on our observations, we recommend serial PSG‐EEG to identify discharges in patients with catamenial‐sleep epilepsy for a more comprehensive diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Studies relating estrogen serum levels and spells provided evidence that this facilitates seizure activity . Administration of estrogen to women with epilepsy has been studied and some researchers found EEG changes in four of 16 individuals .…”

Section: Discussionmentioning

confidence: 99%

Catamenial-sleep epilepsy: A case report

Poblano

Haro

Angel-Alavez

2013

Sleep and Biological Rhythms

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“…Many people with epilepsy have seizures that are more likely to occur during a certain menstrual cycle phase, referred to as ‘catamenial epilepsy’. The prevalence of catamenial epilepsy was first estimated to occur in one out of three women with medication refractory focal epilepsy [5], and subsequent studies showed variations from 6 to 70% [6,7]. A recent prospective, observational 2023 study examining catamenial epilepsy rates showed that 12 out of 23 women with epilepsy, or 52%, demonstrated a catamenial pattern [8 ▪▪ ].…”

Section: Epilepsy and Menstrual Cyclesmentioning

confidence: 99%

“…This review will focus on what is known about fertility in people with epilepsy, describe how menstrual cycles and ART affect epilepsy, and discuss management considerations in women undergoing egg retrieval as part of ART. catamenial epilepsy was first estimated to occur in one out of three women with medication refractory focal epilepsy [5], and subsequent studies showed variations from 6 to 70% [6,7]. A recent prospective, observational 2023 study examining catamenial epilepsy rates showed that 12 out of 23 women with epilepsy, or 52%, demonstrated a catamenial pattern [8 && ].…”

Section: Introductionmentioning

confidence: 99%

Assisted reproductive technology outcomes and management considerations for people with epilepsy

Lemley,

Voinescu

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review Epilepsy is a common neurologic condition amongst people with reproductive capacity, and assisted reproductive technology (ART) is being increasingly utilized. A recent population-based study described favorable outcomes of ART in this population, but other work shows how fluctuating sex hormones may influence medication concentrations and seizures. Recent findings This review discusses hormonal influences on epilepsy and catamenial epilepsy, considerations regarding fertility in women with epilepsy, emerging ART outcomes, and management considerations for people with epilepsy undergoing ART. Summary Utilizing ART is an effective treatment for people with epilepsy desiring pregnancy, but closer monitoring and antiseizure medication adjustments may be needed to ensure the best outcomes. More research is needed to better guide epilepsy care during ART.

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“…[6] Tüm çalışmalara bakıldığında KE prevalansı %10-70 aralığında değişmektedir. [7][8][9][10][11][12][13][14] Bu geniş değişkenlik, adet döngüsüyle ilişkili nöbet alevlenmesini tanımlamak için kullanılan farklı kriterlere, siklus günlüklerinin ve nöbetlerin yanlış kayıt edilmesi gibi metodolojik faktörlere bağlıdır Genel olarak, bu çalışmalar, epilepsili 3 kadından en az 1'inin KE alevlenmesi gösterdiğini destekler ve nöbetler sıklıkla mevcut ilaç tedavilerine dirençlidir. [5][6][7][8]10] Katameniyal epilepsinin patofizyolojisi halen tam olarak bilinmemektedir ancak hayvan modelleri ve epilepsili kadınlarda yapılan çalışmalarda, fizyopatolojisinin, üreme ile ilgili steroid hormonlarının nöroaktif özelliklerine; nörosteroidlerin serumdaki siklik değişikliklerine ve epileptojen odakların nörosteroide etkisine ve duyarlılığına dayandığını düşündürmektedir.…”

Section: Introductionunclassified

Katameniyal Epilepsi

Çelik¹

2018

Epilepsi

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When seizures occur in clusters during certain stages of the menstrual cycle (perimenstrual and periovulatory stages), it is defined as catamenial epilepsy. The prevalence varies between 10% and 70%. There are 3 patterns of catamenial epilepsy: perimenstrual (most common), periovulatory, and seizures in the insufficient luteal phase. In the pathophysiology of this occurrence, the neuroactive properties of the reproduction-associated steroid hormones (direct membrane-associated short-term effect and intracellular receptor/genomic-related longterm effect) and their cyclic changes in serum levels play a role in the susceptibility of the epileptogenic area to neuroactive steroids. Among steroid hormones, while progesterone and neurosteroids are known as anticonvulsants, estrogen, the best known proconvulsant, has been found in recent studies to also have anticonvulsant effects related to Neuropeptide Y. Hormonal (medroxyprogesterone acetate, clomiphene, triptorelin, leuprolide, progesterone, goserelin), non-hormonal (acetazolamide, clobazam, lamotrigine, levetiracetam), and neurosteroidbased therapies (ganaxolone) are used in the treatment of catamenial epilepsy. Seizure control and menstrual cycle maintenance, measurement of the blood level of antiepileptic drugs before and after menstruation and adjustment of the drug dosage as required, intermittent benzodiazepine administration, acetazolamide, or hormonal treatments such as oral contraceptives during menstruation are among the treatment strategies for catamenial epilepsy.

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Occurrence of menstrual cycle related seizure patterns among epileptic women attending the tertiary neurology clinics of the National Hospital of Sri Lanka

Cited by 9 publications

References 20 publications

Catamenial-sleep epilepsy: A case report

Catamenial-sleep epilepsy: A case report

Assisted reproductive technology outcomes and management considerations for people with epilepsy

Katameniyal Epilepsi

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