Occurrence of immune thrombocytopenic purpura in a patient with essential thrombocythemia: How the immune system can overcome a neoplastic clone

Abstract

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Immune thrombocytopenia in a patient with essential thrombocythemia after SARS-CoV-2 infection: A case report

“…In conclusion, we report a case of a patient with ET, who developed ITP during the course of SARS-CoV-2 infection, suggesting that immune-mediated platelet destruction has the ability to overcome the mutated megakaryocytic cell line. 5 , 6 …”

“…It can occur after viral infections, including hepatitis C virus (HCV), human immunodeficiency virus (HIV) and has also recently emerged as a complication of SARS-CoV-2 infection 3 , 4 . To our knowledge, no case of ITP associated with SARS-CoV-2 infection in a patient with ET has been reported and only two case reports of ET with subsequent development of ITP were published, so far 5 , 6 . Here we present a patient with ET, who developed ITP during the course of SARS-CoV-2 infection.…”

Primary Immune Thrombocytopenia and Essential Thrombocythemia: So Different and yet Somehow Similar—Cases Series and a Review of the Literature

“…Nevertheless, the reverse scenario is also possible and interesting. Table 2 shows patients with ET with subsequent development of ITP [6][7][8]. Two out of three cases were female, with the range of age at time of diagnosis between 45 and 95 years.…”

“…In the past few years several cases of immune thrombocytopenia (ITP) which developed into essential thrombocythemia (ET), and in some instances, cases with ET followed by ITP have been reported [1][2][3][4][5][6][7][8].…”

Management of Essential Thrombocythemia in a Patient With a History of Thrombotic Thrombocytopenic Purpura

“…This disease is characterized by an agglomeration of von Willebrand factor multimers that can increase thrombus formation [1]. The thrombi are due to concurrent deficiency of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, protease member 13 (ADAMTS13) activity, which is a protease that cleaves von Willebrand factor [2]. This can lead to a classic pentad of microangiopathic hemolytic anemia, thrombocytopenia, fever, renal dysfunction, and neurological symptoms [3].…”