Occurrence of hyperandrogenism in hirsute patients

Rubens, B.; Verneulen, A.

doi:10.1016/0022-4731(81)90117-5

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Abnormalities In Plasma Protein Transport Of Androgenic Horm1

(3)1

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1983

1984

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“…A high free T concentration was detected in about 70% of hirsute women studied in our laboratory (81). This percentage has been confirmed by Rubens and Vermeulen in highly selected patients (82). Free T levels seem to be uncorrelated with other clinical or laboratory parameters (83) except as already mentioned, for body weight (80).…”

Section: Abnormalities In Plasma Protein Transport Of Androgenic Hormmentioning

confidence: 56%

Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications*

1984

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Section: Abnormalities In Plasma Protein Transport Of Androgenic Hormmentioning

confidence: 56%

Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications*

1984

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“…Finally most authors currently fa vor the dexamethasone suppression test, the results of which seem to be reliable provided that suppression lasts 8-15 days and uses doses too low to modify ovarian function [8,11,13]. However, we feel that these different methods are no longer of practical impor tance in most patients, since 50% of cases of hyperandrogenism are of combined origin [6], and the results of these methods do not influence the actual therapeutic management of the patients.…”

Section: (3)mentioning

confidence: 99%

Investigative Strategy of Hyperandrogenism in Women

Buvat¹,

Dewailly²,

Marcolin³

et al. 1983

Horm Res

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Investigative procedures in the assessment of female hyperandrogenism are reviewed. Based on their experience, the authors suggest an inexpensive investigative strategy in hyperandrogenic females consisting of the following: the first step depends upon the clinical symptoms – in cases of hirsutism with regular menstrual cycles, plasma testosterone (T) and plasma dehydroepiandrosterone sulfate (DHA-S) are assayed, and the basal body temperature chart is recorded. In cases of hirsutism with irregular or anovulatory menstrual cycles, in addition to T and DHA-S, plasma 17-hydroxyprogesterone and urinary-free cortisol are assayed. In case of anovulation without hirsutism, T and DHA-S are assayed, and the LHRH test is performed. The results of this first investigation allow to attribute to the woman one of the six following hormone profiles: (1) metabolic hyperadrenalism; (2) tumoral hyperandrogenism; (3) 21-hydroxylase defect; (4) nontumoral DHA-S increase; (5) nontumoral ovarian hyperandrogenism; (6) idiopathic hirsutism. The additional investigative procedures required in each of these groups are detailed.

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Occurrence of hyperandrogenism in hirsute patients

Cited by 2 publications

References 0 publications

Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications*

Female Hirsutism: Pathophysiological Considerations and Therapeutic Implications*

Investigative Strategy of Hyperandrogenism in Women

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