Occurrence of Glioma of Retina and Brain in Collateral Lines in Same Family

13q Deletion syndrome and retinoblastoma in identical dichorionic diamniotic monozygotic twins

“…A case of an homologous retinoblastoma in identical twins developed from a single ovum was reported by Benedict (13). Duncan and Maynard (14) reported a case of Italian twins affected by bilateral retinoblastoma, which they described sion after 6 cycles of chemotherapy with carboplatin and etoposide, focal therapy (photocoagulation), and 1 cycle of intra-arterial chemotherapy (3 injections of melphalan at intervals of 21 days). Twin 2 was treated with brachytherapy and regression type IV (atrophic chorioretinal scar) was achieved.…”

Chromosome Studies in Patients With Retinoblastoma

“…defects, karyotypes were performed on 21 retinoblastoma patients (17 sporadic, 4 Neurath18 has noted that some of the potentially resolvable detail of the chromosomes seems to be obstructed by either a layer of cytoplasm or the nuclear membrane which covers most of the spreads (Fig 1 and 2) …”