Occurrence of geissoschizine and other minor biogenetically related alkaloids in Rhazya stricta

Banerji, Avijit; Majumder, P.L.; Chatterjee, A.

doi:10.1016/s0031-9422(00)85265-6

Cited by 81 publications

(33 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These alkaloids are found in plants of the Apocynaceae, Rubiaceae and Loganiaceae families (Bruneton, 1995;Verpoorte, 1998). Over 100 alkaloids have been isolated, characterized and identified from R. stricta leaves (Ahmad et al, 1979(Ahmad et al, , 1983Andersen et al, 1987;Atta-ur-Rahman andKhanum, 1985, 1987;, 1987a, 1987bBanerji et al, 1970;Chatterjee et al, 1962;Evans et al, 1968;Habib-ur-Rehman and Atta-ur-Rahman, 1996;Miana et al, 1982;Mukhopadhayay et al, 1981Mukhopadhayay et al, , 1983Schnoes et al, 1962), stems , roots (Ahmad et al, 1970(Ahmad et al, , 1971Atta-ur-Rahman andZaman, 1986a, 1986b;Atta-ur-Rahman et al, 1995Mukhopadhayay et al, 1981;Siddiqui et al, 1966) and legumes (Atta-ur-Rahman and Malik, 1984a, 1984b, as well as from mixtures of aerial parts . Most of them are new chemical compounds, but the pharmacological activities of very few are known (Table 1).…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…Oral pretreatment of mice for 5 consecutive days with an extract of R. stricta protected about 57% of the treated mice against the lethal effect of paracetamol (1 g/kg; Ali et al, 2001). Bashir et al, 1994Mukhopadhayay et al, 1981Mukhopadhayay et al, 1981Atta-ur-Rahman and Khanum, 1984Saeed et al, 1993Bashir et al, 1994Banerji et al, 1970Thoison et al, 1987Siddiqui et al, 1966Ahmad et al, 1970 andMukhopadhayay et al, 1981Mariee et al, 1988Bashir et al, 1994Atta-ur-Rahman and Malik, 1987Evans et al, 1968Mukhopadhayay et al, 1981Bashir et al, 1994Mukhopadhayay et al, 1981Mukhopadhayay et al, 1981Mukhopadhayay et al, 1981Pawelka and...…”

Section: Pharmacological and Toxicological Actions Of Rhazya Strictamentioning

confidence: 99%

See 1 more Smart Citation

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Gilani

Kikuchi

Shinwari

et al. 2006

Phytotherapy Research

View full text Add to dashboard Cite

Rhazya stricta Decne. is an important medicinal species that is rich in alkaloids containing anticancer alkaloids also. This paper reviews phytochemical, pharmacological and ethnobotanical studies of R. stricta. Phytochemical and pharmacological aspects of the species have been thoroughly explored. Over 100 alkaloids have been isolated from R. stricta, but the pharmacological activities are known for only a few of these compounds. Very few ethnobotanical studies of R. stricta have been done, and there is a particular need for such studies in various regions of South Asia and in Middle Eastern countries where the species grows. These ethnobotanical studies should investigate herbal recipes of R. stricta and their use for curing diseases. The genetic diversity, chemotaxonomy and allelopathy of R. stricta have not yet been explored, and these studies are recommended, with the ultimate goal of benefiting local communities in regions where R. stricta grows. This should be achieved by sharing knowledge and through the manufacture of herbal drugs from R. stricta's active chemical constituents, while protecting intellectual property rights and following the World Health Organization's guidelines for safety and efficacy.

show abstract

Section: Chemical Constituentsmentioning

confidence: 99%

Section: Pharmacological and Toxicological Actions Of Rhazya Strictamentioning

confidence: 99%

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Gilani

Kikuchi

Shinwari

et al. 2006

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The plant is used in the United Arab Emirates as folk medicine in the treatment of diabetes mellitus, inflammatory conditions and helminthiasis. Despite extensive phytochemical research on R. stricta (Baherji et al 1970;Rahman et al 1988;Bashir et al 1994), little work seems to have been published on the pharmacological properties of this plant (Wasfi et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Activity of Rhazya Stricta (Decne) in Mice

Ali¹,

Bashir²,

Banna

et al. 1995

Clin Exp Pharma Physio

View full text Add to dashboard Cite

1. The effects of orally administered aqueous lyophilized extract of the leaves of Rhazya stricta (2, 4 & 8 g/kg) on aspects of nervous system function were investigated in mice. 2. In three antinociceptive tests (hot plate, abdominal constriction, and warm water tail flick tests), the extract exhibited dose-dependent and significant antinociceptive activity. Naloxone was ineffective in antagonizing the analgesic effect of Rhazya stricta on tail-flick and abdominal constriction tests, possibly indicating that this effect occurs via non-opiate pathways. 3.Pretreatment of mice with the xenobiotic metabolizing enzymes inhibitor cimetidine (50 mg/kg) did not significantly alter the antinociceptive action of the extract, indicating that the effect is probably due to the parent compound(s) present in the extract and not to metabolites thereof. 4. Rhazya stricta produce dose-dependent sedation, decreased motor activity, and impaired motor control. Time spent on a rotarod treadmill was significantly decreased after treatment with the extract. 5. Rhazya stricta extract (8 g/kg) produced a degree of sedation comparable to that produced by diazepam (5-10 mg/kg), and also significantly increased the reaction time of the tail-flick test, an action which was not produced by diazepam. 6. Administration of R. stricta extract potentiated pentobarbitone sleeping time in a dose dependent manner. The extract did not significantly antagonize picrotoxin induced convulsions. The extract (4 and 8 g/kg) significantly decreased the rectal temperature of normothermic and hyperthermic mice. 7. Pretreatment with R. stricta extract (8 g/kg) completely prevented the occurrence of aggressive behaviour in male mice. 8. It is concluded that the crude extract of R. stricta has central nervous system depressant properties.

show abstract

“…(−)-Rhazinilam ( 44 ) has been isolated from various plants including Rhazya strica decaisne [68], Melodinus australis [69], and Kopsia singapurensis [70]. Shortly after the first isolation, its structure was elucidated by single crystal X-ray diffraction analysis [71].…”

Section: Resultsmentioning

confidence: 99%

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

Liu¹,

Liniger²,

McFadden³

et al. 2014

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

SummaryPd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of “classic” natural product target molecules. This publication highlights recent methods for setting quaternary and tetrasubstituted tertiary carbon stereocenters to address the synthetic hurdles encountered over many decades across multiple compound classes spanning carbohydrate derivatives, terpenes, and alkaloids. These enantioselective methods will impact both academic and industrial settings, where the synthesis of stereogenic quaternary carbons is a continuing challenge.

show abstract

Occurrence of geissoschizine and other minor biogenetically related alkaloids in Rhazya stricta

Cited by 81 publications

References 6 publications

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Phytochemical, pharmacological and ethnobotanical studies of Rhazya stricta Decne.

Central Nervous System Activity of Rhazya Stricta (Decne) in Mice

Formal total syntheses of classic natural product target molecules via palladium-catalyzed enantioselective alkylation

Contact Info

Product

Resources

About