Occurrence of epithelial dysplasia in oral leukoplakia

Bánóczy, J; Csiba, A

doi:10.1016/0030-4220(76)90099-2

Cited by 202 publications

(87 citation statements)

References 7 publications

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“…The preneoplastic lesions were classified into two categories of hyperplasia (simple and papillary) and three types of dysplasia (mild, moderate, and severe) according to the degree of atypism present. 32,33) The incidences of total preneoplasia in groups 2 (73.7%) and 3 (75.0%) were significantly lower than that of group 1 (100%, P<0.05). Although the incidences of simple hyperplasia of groups 1-3 were comparable, the incidence of papillary hyperplasia in group 2 (42.1%, P<0.05) was lower than that in group 1 (79.2%).…”

Section: Resultsmentioning

confidence: 90%

“…The sections were used for hematoxylin and eosin staining and immunohistochemistry of the expression of cell proliferation biomarkers (BrdU-labeling index and cyclin D1-positive cell ratio) and of COX-2 and PPARγ. Tongue epithelial lesions (hyperplasia, dysplasia and neoplasia) in the oral cavity were diagnosed according to the criteria described by Banoczy and Csiba 32) and WHO.…”

Section: Methodsmentioning

confidence: 99%

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Inhibitory effects of troglitazone, a peroxisome proliferator‐activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4‐nitroquinoline 1‐oxide

Yoshida

Hirose²,

Tanaka

et al. 2003

Cancer Science

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Ligands for peroxisome proliferator-activated receptor (PPAR) γ γ γ γ have been implicated in growth inhibition and cell differentiation in certain malignancies. In this study, the effects of troglitazone, a PPARγ γ γ γ ligand, given during the postinitiation phase of oral carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO) were investigated in male F344 rats. Rats aged 6 weeks were given 4-NQO at 20 ppm for 8 weeks to induce tongue neoplasms. Starting 1 week after the cessation of 4-NQO exposure, animals were fed diets containing 0, 30 or 100 ppm troglitazone for 22 weeks. At the end of the study (week 32), the incidences of 4-NQO-induced tongue neoplasms and preneoplasms were determined histopathologically and cell proliferation activity was estimated by counting bromodeoxyuridine (BrdU)-labeling indices and cyclin D1-positive cell ratios. In addition, immunohistochemical expression of cyclooxygenase (COX)-2 and PPARγ γ γ γ was assessed in the tongue lesions. Feeding with 100 ppm troglitazone significantly decreased the incidence of squamous cell carcinoma when compared to the group without troglitazone treatment (5.0% vs. 45.8%, P < < < <0.005). Interestingly, the BrdU-labeling index and cyclin D1-positive cell ratio assessed in the non-lesional tongue squamous epithelium were reduced by dietary administration of troglitazone (P < < < <0.0001-0.005). Additionally, the immunoreactivity of COX-2 in the tongue lesions was also decreased by the treatment (P < < < <0.01-0.05). These results clearly showed that dietary troglitazone inhibits 4-NQO-induced tongue carcinogenesis and such inhibition is related to suppression of increased cell proliferation and/or COX-2 expression. This study warrants further investigation on the use of PPARγ γ γ γ ligands as a novel preventive approach for oral malignancy. (Cancer Sci 2003; 94: 365-371) he nuclear receptor superfamily acts as ligand-responsive transcription factors that participate in many processes important for cell and tissue homeostasis. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor superfamily that includes receptors for steroids, thyroid hormone, vitamin D or retinoic acid.1) At present, several PPARs including PPARα, PPARβ (PPARδ, NUC-1, or FAAR), and PPARγ have been identified.2) Of these, PPARγ was initially shown to have regulatory roles in insulin sensitization. 3,4) The receptor binds to the promoter region of target genes involved in adipocyte differentiation and lipid storage [4][5][6] as a heterodimer with the retinoid X receptor.7) Activation of this receptor has been implicated in glucose metabolism, cell cycle control, and macrophage development and function. [8][9][10][11][12] In addition, recent studies suggest that PPARs play an important role in carcinogenesis. 13) 15-Deoxy-δ-prostaglandin J 2 , a natural-occurring metabolite of prostaglandin D 2 , and troglitazone, a thiazolidinedione analogue and a synthetic anti-diabetic drug, have been reported to be selective ligands for PPARγ.9, 14, 15) Re...

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Section: Resultsmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Inhibitory effects of troglitazone, a peroxisome proliferator‐activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4‐nitroquinoline 1‐oxide

Yoshida

Hirose²,

Tanaka

et al. 2003

Cancer Science

View full text Add to dashboard Cite

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“…For histologic examination, tissue and gross lesions were fixed in 10% buffered formalin, embedded in paraffin blocks, and the histologic sections were stained with hematoxylin and eosin. Epithelial lesions (hyperplasia, dysplasia, and neoplasia) in the oral cavity were diagnosed according to the criteria described by Banoczy and Csiba and Kramer and colleagues (20,21). The diagnosis was randomized and single blinded.…”

Section: Animals Diets and Experimental Proceduresmentioning

confidence: 99%

Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide

Zhang

Wang

Jiang

et al. 2013

Cancer Prevention Research

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Despite significant advances in cancer therapy, cancer-related mobility and mortality are still rising. Alternative strategies such as cancer prevention thus become essential. Probiotics represent an emerging option for cancer prevention, but studies are limited to colon cancers. The efficiency of probiotics in the prevention of other cancers and the correlative mechanism remains to be explored. A novel probiotics Lactobacillus salivarius REN (L. salivarius REN) was isolated from centenarians at Bama of China, which showed highly potent antigenotoxicity in an initial assay. 4-nitroquioline 1-oxide (4NQO)-induced oral cancer model was introduced to study the anticancer activity of L. salivarius REN in vivo. The results indicated that oral administration of probiotic L. salivarius REN or its secretions could effectively suppress 4NQO-induced oral carcinogenesis in the initial and postinitial stage, and the inhibition was in a dose-dependent manner. A significant decrease of neoplasm incidence (65%-0%) was detected in rats fed with the high dose of L. salivarius REN [5 Â 10 10 CFU/kg body weight (bw)/d]. In vivo evidences indicated that the probiotics inhibited 4NQO-induced oral cancer by protecting DNA against oxidative damage and downregulating COX-2 expression. L. salivarius REN treatment significantly decreased the expression of proliferating cell nuclear antigen (PCNA) and induced apoptosis in a dose-dependent manner. Our findings suggest that probiotics may act as potential agents for oral cancer prevention. This is the first report showing the inhibitory effect of the probiotics on oral carcinogenesis. Cancer Prev Res; 6(7); 686-94. Ó2013 AACR.

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“…The oral SCC is often preceded by premalignant lesions (dysplasias) which are clinically diagnosed as leukoplakia or erythroplakia. Long-term follow-up studies showed that 11-36% of oral epithelial dysplasias transformed into SCC (22)(23)(24)(25), and that severe dysplasias were generally associated with a higher risk for malignant transformation than mild and moderate ones (25). Thus, oral SCC, if not all, is likely to develop in normal-dysplasia-carcinoma sequence.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues

et al. 2006

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Human HOX genes consist of 39 genes and encode transcription factors that function as master developmental regulators. We hypothesized that the misexpression of HOX genes was associated with carcinogenesis and malignant progression. The expression levels of 39 HOX genes in 31 human oral squamous cell carcinoma (SCC), 11 dysplasia and 10 normal mucosa tissues were quantified by the real-time RT-PCR method. The expression levels of 18 HOX genes in the SCC tissues were significantly higher than those in the normal mucosa tissues. The dysplasia tissues showed higher expression of HOXA2, A3, B3 and D10 than normal mucosa tissues whereas they showed lower expression of HOXA1, B7, B9 and C8 than SCC. The SCC with lymph node metastasis showed high expression of HOXC6 compared to the SCC without it.These results suggest that misexpressions of particular HOX genes are implicated in the development of oral dysplasia and SCC.2

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Occurrence of epithelial dysplasia in oral leukoplakia

Cited by 202 publications

References 7 publications

Inhibitory effects of troglitazone, a peroxisome proliferator‐activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4‐nitroquinoline 1‐oxide

Inhibitory effects of troglitazone, a peroxisome proliferator‐activated receptor γ ligand, in rat tongue carcinogenesis initiated with 4‐nitroquinoline 1‐oxide

Lactobacillus Salivarius REN Inhibits Rat Oral Cancer Induced by 4-Nitroquioline 1-Oxide

Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues

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