Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients

Kowalczyk, Marek; Orlowski, M; Siermontowski, Piotr; Mucha, Dariusz; Zinkiewicz, Krzysztof; Kurpiewski, Waldemar; Zieliński, Ewa; Kowalczyk, Iwona; Pedrycz, Agnieszka

doi:10.1186/s12885-018-4100-8

Cited by 15 publications

(20 citation statements)

References 41 publications

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“…Differences in the amount of dysplastic ACF in comparable groups may result from ethnic, dietary and environmental differences [6,17,18]. As we showed in our other work [12], a greater number of ACFs occur in people with obesity (especially with BMI > 35 kg / m2), a diet with excess red meat and a low-residual diet, which is also confirmed by other authors [13,15].…”

Section: Discussionsupporting

confidence: 87%

“…These results also show a substantial increase in the number of ACF from the age of 50. We presented similar data in another study [12]. As you can see in Fig.…”

Section: Discussionsupporting

confidence: 84%

“…A very significant fact is that in people over 80 years old the number of ACF no longer increases. On the contrary, there is an observable decrease in their number [12]. Presumably, in individuals over the age of 80 an atrophy of the mucous membrane occurs in the distal section of the large intestine, with the regeneration process not being as intense as in younger people.…”

Section: Discussionmentioning

confidence: 97%

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Rectal aberrant crypt foci (ACF) as a predictor of benign and malignant neoplastic lesions in the large intestine

Kowalczyk

Orlowski²,

Klepacki³

et al. 2020

BMC Cancer

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Background: The importance of ACF is not fully explained, however, their number may be a good predictor of synchronous and metachronic adenoma or other polyps whose removal reduces the risk of CRC. Due to the epidemiological and genetic association of ACF with pre-cancer lesions, they may be a potential CRC biomarker. The aim of our study was to show that the number and type of rectal ACF may be a good predictive factor for the presence of polyps located proximally from the splenic flexure and that the type and number of ACF can correlate with the number and specific types of polyps in the large intestine. Methods: The study included 131 patients who underwent colonoscopy combined with rectal mucosa staining with 0.25% methylene blue. The number of rectal ACF was determined and bioptats were sampled for histopathological examination to assess the type of ACF. Endoscopic ACF assessment criteria given by L. Roncucci were used. The obtained material was subjected to statistical analysis using probability distribution, U-test, t-student test, and chi 2 as well as the Statistica 7.1 software package. Results: The study population was divided into three subgroups according to the number of ACF observed, i.e. ACF < 5, 5-10 and > 10. ACF < 5 were found in 35 patients (29.41%), 5-10 ACF in 70 (58.82%) and ACF > 10 in 14 individuals (11.76%). The study revealed the presence of normal ACF (p = 0.49), hyperplastic ACF (p = 0.34), dysplastic ACF (p = 0.11), and mixed ACF (p = 0.06). A single type of ACF was most commonly observed (n = 88, p = 0.74). In the researched group a larger number of ACF is concurrent with adenomas and hyperplastic polyps. The number of ACF clearly correlates with the dysplasia advancement in the adenoma and the number of polyps found. Conclusions: Rectal ACF are a useful marker for the presence of cancerous lesions in the proximal and distal sections of the large intestine.

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Section: Discussionsupporting

confidence: 87%

“…These results also show a substantial increase in the number of ACF from the age of 50. We presented similar data in another study [12]. As you can see in Fig.…”

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 97%

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Rectal aberrant crypt foci (ACF) as a predictor of benign and malignant neoplastic lesions in the large intestine

Kowalczyk

Orlowski²,

Klepacki³

et al. 2020

BMC Cancer

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“…The relative risk of toxins related changes depends on the number of cigarettes smoked per day and duration of smoking. The ingredients of tobacco smoke in combination with an incorrect diet increase the risk of CRC formation [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Smoking on the Number and Type of Rectal Aberrant Crypt Foci (ACF)—First Identifiable Precursors of Colorectal Cancer (CRC)

Kowalczyk

Klepacki

Zieliński

et al. 2020

JCM

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Background: The problem of smoking and its influence on the occurrence of precursors and advanced colorectal cancer is often discussed in the medical literature. Tobacco smoke can provide a non-nutritional source of polycyclic hydrocarbons and other substances which, when combined with an incorrect diet, may play a role in promoting carcinogenesis at the level of the genetic control mechanism. The aim of our study was to assess the effect of smoking on the frequency and type of aberrant crypt foci (ACF) in the rectum and polyps in the large intestine in people who smoke more than 20 cigarettes a day for more than 20 years. Methods and Findings: A colonoscopy combined with rectal mucosa staining with 0.25% methylene blue was performed in 131 patients. Each of the study participants gave informed consent to participate in the study. Three bioptates were collected from the foci defined macroscopically as ACF; in cases where there were fewer foci, the number of collected foci was respectively lower. On the colonoscopy day, patients completed the questionnaire regarding epidemiological data used for analysis of factors affecting the occurrence of ACF in the study group. The number of ACF in the colon was divided into three groups: −ACF < 5, 5 < ACF < 10, ACF > 10. In the statistical analysis, numerical data were presented and real numbers, range of arrhythmic means, mean standard deviation, and results of probability distribution. The Student’s test, U test, and chi2 were applied in order to determine the significance of differences of means and frequency of events in both groups. The level of significance was set at α = 0.05. Statistica 7.1 and Excel 2010 were used. Most smokers are in the age groups between 51–70 years. In the youngest (31–40 years), single ACF appear first (ACF <5) ACF in the number of 5–10 appear a little later (around 50 years of age) and dynamically increase, reaching a maximum at the age of 60–65.ACF in the number >10 appear at the latest age (55 years old) and their number gradually increases with age (linear growth). The probability of occurrence of ACF in all groups is greater in smokers, and the difference for the ACF group 5-10 and ACF >10 is statistically significant with a significance level of p < 0.05. Apart from ACF normal, all types of ACF are more likely in this group than in non-smokers and these differences are statistically significant with p < 0.05. Conclusions: Smoking has a significant impact on the number and type of rectal ACF. Smokers have a greater number of ACFs in the rectum than non-smokers, and the most common type is hyperplastic ACF. Smokers are more likely to develop polyps in all sections of the colon compared to non-smokers.

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“…Savaş döneminde Turan Derneği daha aktif bir rol oynamıştır. Macaristan'daki siyasi elitlerin desteğini alan dernek, Macar toplumunun ileri gelenlerinin katılımına sahne olmuştur 51. Gyula Gömbös ve Balint Homan gibi ünlü siyasetçiler derneğin üyesi olmuştur.…”

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Macarlar, Macaristan ve Turancılık

Duran¹,

Orhun²

2019

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Farsça kökenli Turan kelimesi günümüzde tüm Türk boylarının yaşadığı yer manasında kullanılmaktadır. Bu ideolojik anlamı 19. ve 20. yüzyılda Macar dilbilimciler ve tarihçiler tarafından geliştirilmiştir. Macaristan'da 20. yüzyılın ilk yarısında güçlü bir Turancı ideolojik hava hâkim olmuştur. Bu yüzden Turancılık, Macarlarla özdeşleştirilmiştir. Macar Turancılığı, Avrupa'nın ortasında yalnızlık ve iktisadi sıkıntılarla doğmuş ve güçlenmiştir. İkinci Dünya Savaşı'ndan sonra Turan düşüncesi dondurulmuşsa da bugün, bu tarihsel ideoloji Macaristan'da tekrar canlanmaya başlamıştır. Ülkedeki AB ve Batı karşıtlığı Turan ideolojisi üzerinden dillendirilmektedir. Bu düşünceler, Macaristan'ın ana muhalefet partisi JOBBİK ve Macar Turan Vakfı tarafından sık sık dile getirilmektedir. Sovyetler Birliği'nin çökmesiyle birlikte Macaristan'daki AB ile entegrasyon süreci, ülkenin mali kriz içerisinde olması ve dış borçlanman, Macaristan'da tekrar "Turan" düşüncesini uyanmasını sağlamıştır. Türkiye'deki Turancılık anlayışı ise biraz daha romantik olmakla birlikte "kardeş Macar" fikri ağır basamaktadır. Macaristan'da Turancı ideolojiye sahip bir parti olarak görülen Jobbik'in söylemlerindeki "Doğu'ya dönüş" ilk bakışta "Batı'dan bir Doğu'ya dönüş" gibi gözükmekle birlikte, bu söylemin temelinde yatan asıl sebebin Avrupa'da yaşanan ekonomik darboğazdan ve Macar ekonomisinin içinde bulunduğu krizden kaynaklandığını söylemek de mümkündür.

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Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients

Cited by 15 publications

References 41 publications

Rectal aberrant crypt foci (ACF) as a predictor of benign and malignant neoplastic lesions in the large intestine

Rectal aberrant crypt foci (ACF) as a predictor of benign and malignant neoplastic lesions in the large intestine

The Effect of Smoking on the Number and Type of Rectal Aberrant Crypt Foci (ACF)—First Identifiable Precursors of Colorectal Cancer (CRC)

Macarlar, Macaristan ve Turancılık

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