Occurrence of Chronic Renal Failure in Liver Transplantation: Monitoring of Pre- and Posttransplantation Renal Function

Umbro, I.; Tinti, Francesca; Piselli, Pierluca; Fiacco, F.; Giannelli, V.; Natale, V. Di; Zavatto, A.; Merli, Manuela; Rossi, Massimo; Corradini, Stefano Ginanni; Poli, L.; Berloco, P.B.; Mitterhofer, Anna Paola

doi:10.1016/j.transproceed.2012.06.012

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…This highlights the importance of proper long‐term follow‐up in these patients, especially those with an eGFR <60 mL/min/1.73 m 2 at baseline. In prior studies, CKD has been thought to be related to nephrotoxicity of CNI, but other factors may contribute such as concomitant hypertension, diabetes, hepatitis C, and chronic thrombotic microangiopathy . In fact, the use of CNI within 48H and within 1 month was significantly lower in patients with AKI.…”

Section: Discussionmentioning

confidence: 97%

Impact of acute kidney injury following liver transplantation on long‐term outcomes

Trinh

Alam

Tchervenkov

et al. 2016

Clinical Transplantation

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Section: Discussionmentioning

confidence: 97%

Impact of acute kidney injury following liver transplantation on long‐term outcomes

Trinh

Alam

Tchervenkov

et al. 2016

Clinical Transplantation

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“…AKI after liver transplantation is a frequent complication occurring in up to two-thirds of patients [ 88 , 89 ], leads to at least temporary need of renal replacement therapy in up to 30% of these cases [ 90 ], is a risk factor for CKD [ 89 ] and associated with increased mortality. The most common reasons for AKI after liver transplantation are ischaemia-induced acute tubular necrosis, nephrotoxic drug reactions especially due to immunosuppressive agents, a pre-existing hepatorenal syndrome and a poor preoperative condition of the patient [ 88 ].…”

Section: Aki and Liver Transplantationmentioning

confidence: 99%

From the nephrologist's point of view: diversity of causes and clinical features of acute kidney injury

2015

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Acute kidney injury (AKI) is a clinical syndrome with multiple entities. Although AKI implies renal damage, functional impairment or both, diagnosis is solely based on the functional parameters of serum creatinine and urine output. The latest definition was provided by the Kidney Disease Improving Global Outcomes (KDIGO) working group in 2012. Independent of the underlying disease, and even in the case of full recovery, AKI is associated with an increased morbidity and mortality. Awareness of the patient's individual risk profile and the diversity of causes and clinical features of AKI is pivotal for optimization of prophylaxes, diagnosis and therapy of each form of AKI. A differentiated and individualized approach is required to improve patient mortality, morbidity, long-term kidney function and eventually the quality of life. In this review, we provide an overview of the different clinical settings in which specific forms of AKI may occur and point out possible diagnostic as well as therapeutic approaches. Secifically AKI is discussed in the context of non-kidney organ failure, organ transplantation, sepsis, malignancy and autoimmune disease.

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“…CKD is common after organ transplantation, mainly during recovery from liver transplantation [70]. A review of 46 observational studies between 1990 and 2019 [15,20,24,28,31,43,[49][50][51]66, showed that CKD is observed in 10% to 75% of liver-transplant patients beyond 20 years post-transplantation. This wide variability is due to inhomo-geneous definitions, measurement methods, and lengths of follow up between studies.…”

Section: Post-transplantation Chronic Kidney Disease and End-stage Renal Diseasementioning

confidence: 99%

“…Post-operative risk factors for AKI are represented by markers of the severity of the condition, such as mechanical ventilation, length of hospitalization (including in intensive care unit), infectious complications, hemodynamic instability or a high APACHE II score [8,23,25,36,60]. The importance of liver function is also accentuated since the occurrence of AKI is predicted by a lack of recovery of liver function, acute rejection, cholestasis and peak cytolysis [31,42,116]. The occurrence of AKI within 6 to 12 months after transplantation is associated with an increase in the risk of chronic renal disease within 5 years after transplantation [46,62,71,75,76,79,83,87].…”

Section: Post-operative Risk Factorsmentioning

confidence: 99%

Kidney Failure after Liver Transplantation

et al. 2021

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One-third of patients with cirrhosis present kidney failure (AKI and CKD). It has multifactorial causes and a harmful effect on morbidity and mortality before and after liver transplantation. Kidney function does not improve in all patients after liver transplantation, and liver transplant recipients are at a high risk of developing chronic kidney disease. The causes of renal dysfunction can be divided into three groups: pre-operative, perioperative and post-operative factors. To date, there is no consensus on the modality to evaluate the risk of chronic kidney disease after liver transplantation, or for its prevention. In this narrative review, we describe the outcome of kidney function after liver transplantation, and the prognostic factors of chronic kidney disease in order to establish a risk categorization for each patient. Furthermore, we discuss therapeutic options to prevent kidney dysfunction in this context, and highlight the indications of combined liver–kidney transplantation.

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Occurrence of Chronic Renal Failure in Liver Transplantation: Monitoring of Pre- and Posttransplantation Renal Function

Cited by 10 publications

References 13 publications

Impact of acute kidney injury following liver transplantation on long‐term outcomes

Impact of acute kidney injury following liver transplantation on long‐term outcomes

From the nephrologist's point of view: diversity of causes and clinical features of acute kidney injury

Kidney Failure after Liver Transplantation

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