Occurrence of Certain Multiple Primary Cancers in Females2

Schoenberg, Bruce S.; Greenberg, Richard A.; Eisenberg, Henry

doi:10.1093/jnci/43.1.15

Cited by 138 publications

(7 citation statements)

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“…Synchronous multiple primary tumors of the female genital tract account for only 1-6% of all genital neoplasms. In the literature, the coexistence of endometrial cancer and ovarian cancer is the most frequently observed synchronous tumor occurrence, like in our study ( 17 , 18 ) . There are no data about the coexistence of cervical cancer and Brenner tumors in the literature; one (4.5%) patient had a grade 2 cervical cancer in our study.…”

Section: Discussionsupporting

confidence: 78%

Features of ovarian Brenner tumors: Experience of a single tertiary center

Turgay¹,

Koyuncu²,

Taşkın³

et al. 2017

tjod

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Objective:Brenner tumors are rare neoplasms of the ovary. The aim of this study was to investigate the clinical features of Brenner tumors.Materials and Methods:The clinical features of 22 patients who were treated in Ankara University Faculty of Medicine Obstetrics and Gynecology Department between 2005 and 2015 were evaluated retrospectively from hospital medical records.Results:The patients were aged 34 to 79 years at the time of diagnosis and the mean age was 55.1 years. Two (9.1%) patients were pre-menopausal, five (22.7%) were peri-menopausal, and 25 (68.2%) patients were postmenopausal. One patient was pregnant. Twenty of the neoplasms were benign, one was malignant, and one was both malignant and benign. There was no recurrence in the malignant cases. Six (27.2%) patients had mixed tumors consisting of Brenner tumor and another ovarian pathology. Specifically, the other component of these tumors was mucinous cystadenoma in four patients, endometriosis externa in one patient, and high-grade serous papillary cyst adenocarcinoma in one patient.Conclusion:Brenner tumors are usually incidental benign pathologic findings of surgical procedures in postmenopausal women. They can be found with other ovarian pathologies such as mucinous ovarian tumors and can coexist with other female genital tumors. Further studies are needed to completely understand the clinical features of Brenner tumors.

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Section: Discussionsupporting

confidence: 78%

Features of ovarian Brenner tumors: Experience of a single tertiary center

Turgay¹,

Koyuncu²,

Taşkın³

et al. 2017

tjod

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“…The incidence of metachronous second cancer varies among studies, and the discrepancies in the type of second cancer is influenced by several factors including race, hormone status, environment, and genetic disposition. Studies have provided consistent findings in terms of excesses of various cancer sites for cancer of the endometrium [ 7 , 10 , 14 ], thyroid cancer [ 2 , 7 , 9 - 12 , 14 , 15 ], and ovarian cancer [ 2 , 9 , 10 , 12 , 13 , 16 , 17 ]. Breast, ovary, and endometrial cancers may have a common etiology, with high fat diet, effect of sex hormone levels, and reduced fertility being candidate factors [ 9 ].…”

Section: Discussionmentioning

confidence: 93%

Metachronous Double Primary Cancer after Treatment of Breast Cancer

Kim

Song

1970

Cancer Res Treat

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PurposeThe pattern of double primary cancer after treatment for breast cancer is important for patient survival.Materials and MethodsWe analyzed 108 cases of metachronous double primary cancer in breast cancer patients treated from 1999 to 2012.ResultsMetachronous double primary cancers occurred in 108 of 2,657 patients (4.1%) with breast cancer. The median time to the occurrence of second cancer after diagnosis of the first was 58.4±41.2 months (range, 6.9 to 180.2 months). The most common cancer was thyroid cancer, which occurred in 45 patients (41.7%). This was followed by gastric cancer in 16 patients (14.8%), endometrial cancer in 10 patients (9.3%), and cervical cancer in seven patients (6.5%). The relative risk showed a significant increase in endometrial (4.78; 95% confidence interval [CI], 1.66 to 13.79), gastric (2.61; 95% CI, 1.68 to 4.06), and thyroid cancer (1.95; 95% CI, 1.37 to 2.79). At 5 years after diagnosis of breast cancer, secondary cancer occurred in 48 patients (44.4%), with 50.0% of the endometrial, 56.3% of the stomach, and 37.8% of the thyroid cancer cases being diagnosed after 5 years. Median survival after diagnosis of the second cancer was 123.9±11.2 months. The prognosis was mainly influenced by the anatomic site.ConclusionThe incidence of endometrial, stomach, and thyroid cancer increased significantly after treatment with primary breast cancer, and survival was dependent on early detection and the type of second primary cancer. A prolonged follow-up examination for metachronous double primary cancer is needed to provide early detection and improve survival time in patients with breast cancer.

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“…The question of whether a second malignancy occurs randomly or with a significant tendency has been debated since the first reports of multiple unrelated neoplasms. 1,5,6 For patients with cutaneous melanoma, a significant predisposition for development of second malignancies has been repeatedly reported in the literature. [2][3][4] In particular, close associations have been drawn between malignant melanoma and breast cancer, kidney cancer and non-Hodgkin's lymphomas 3,7-10 and only a few reports indicate lack of higher frequency of non-cutaneous neoplasms in patients with malignant melanoma.…”

Section: Discussionmentioning

confidence: 96%

“…The question of whether a second malignancy occurs randomly or with a significant tendency has been debated since the first reports of multiple unrelated neoplasms 1,5 , 6 . For patients with cutaneous melanoma, a significant predisposition for development of second malignancies has been repeatedly reported in the literature 2–4 .…”

Section: Discussionmentioning

confidence: 99%

Lymphadenopathy detected by ultrasound examination as first diagnostic hint of chronic lymphocytic leukaemia in a patient with melanoma

Lebeau²,

Ca³

et al. 2002

Acad Dermatol Venereol

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Recent reports indicate that patients with malignant melanoma might be at higher risk for developing a non-cutaneous unrelated second malignancy. We describe the case of a 46-year-old woman who had a malignant melanoma on her right shoulder that was treated in 1998 by surgical excision combined with axillary lymph node dissection. In 1999, ultrasound examination of peripheral lymph nodes revealed one suspicious echopoor structure in the woman's right axilla that was not palpable. Diagnostic excision and histopathological examination revealed a small B-cell lymphocytic lymphoma, and further investigations led to a diagnosis of chronic lymphocytic B-cell leukaemia (B-CLL). We would like to point out the value of high-resolution ultrasound examination in the follow-up of patients with malignant melanoma; this examination can detect early metastasis as well as other unrelated malignancies.

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Occurrence of Certain Multiple Primary Cancers in Females2

Cited by 138 publications

References 0 publications

Features of ovarian Brenner tumors: Experience of a single tertiary center

Features of ovarian Brenner tumors: Experience of a single tertiary center

Metachronous Double Primary Cancer after Treatment of Breast Cancer

Lymphadenopathy detected by ultrasound examination as first diagnostic hint of chronic lymphocytic leukaemia in a patient with melanoma

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