Occurrence of both bladder and prostate cancer in five cancer registries in Belgium, The Netherlands and the United Kingdom

Kellen, Eliane; Zeegers, Maurice P.; Dirx, M.J.M.; Houterman, Saskia; Droste, Jos; Lawrence, Gill; Truyers, Carla; Bruckers, Liesbeth; Molenberghs, Geert; Joniau, Steven; Buntinx, Frank

doi:10.1016/j.ejca.2007.04.011

Cited by 31 publications

(33 citation statements)

References 21 publications

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“…Relevant to the urological clinical practice, our results indicated that men older than 60 years affected by prostate cancer show an excess of second primary bladder tumours. Previous studies have shown that detection bias may have an important role in the first year of follow-up, and our results confirmed this statement (Kellen et al, 2007). Out of 1721 patients affected by bladder after prostate cancer, (1721À1000)/1721 ¼ 42% were diagnosed with the two tumours within 1 year.…”

Section: Discussionsupporting

confidence: 80%

“…The within-patient clustering of bladder and prostate tumours has been extensively explored (Liauw et al, 2006;Bostrom and Soloway, 2007;Kellen et al, 2007;Bostrom et al, 2008;Singh et al, 2008). In contrast with testicular cancer, which showed increasing SIRs with increasing latency times, the SIRs of bladder neoplasms decreased with the time after diagnosis of prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The second approach investigated the pattern of risk after first tumours: asynchronous constant or decreasing relative risks may favour shared risk factors, whereas increasing risks with increasing lead time should point to treatment effects (Heard et al, 2005). There is an excellent literature on the development of bladder tumours after specific types of cancer, for example after prostate, oesophageal, testicular, cervical and lung tumours, and after lymphomas (Kaldor et al, 1987;Pettersson et al, 1990;Pathak Bjorge et al, 1995;Bokemeyer and Schmoll, 1995;Travis et al, 1995Travis et al, , 1997Levi et al, 1996Levi et al, , 1999Fisher et al, 1997;Teppo et al, 2001;Dores et al, 2002;Brennan et al, 2005;Heard et al, 2005;Liauw et al, 2006;Bostrom and Soloway, 2007;Chaturvedi et al, 2007;Kellen et al, 2007;Landgren et al, 2007;Muller et al, 2007;Chuang et al, 2008;Singh et al, 2008). The main advantage of this study was the simultaneous investigation of the most common types of cancer before bladder tumours using a uniform reference population.…”

Section: Discussionmentioning

confidence: 99%

“…Tobacco smoking, occupational exposure to aromatic and heterocyclic amines, and probably chronic bladder infections are established risk factors for bladder cancer (Nordlund et al, 1997;Brennan et al, 2000Brennan et al, , 2001IARC, 2004;Gandini et al, 2008;Kiemeney et al, 2008). Variants in genes coding for xenobiotictransforming enzymes and polymorphisms in DNA repair genes may also modify cancer susceptibility (Easton et al, 2007;Kellen et al, 2007;Murta-Nascimento et al, 2007b;Sanderson et al, 2007;Andrew et al, 2008). In addition to detection bias and risk factors shared by cancer of distinct types, for example, tobacco smoking is a risk factor for both lung and bladder cancers, second primary neoplasms may be related to the treatment of the first tumour.…”

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confidence: 99%

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Bladder cancer in cancer patients: population-based estimates from a large Swedish study

Bermejo

Sundquist²,

Hemminki

2009

Br J Cancer

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BACKGROUND: This study quantified the risk of urinary bladder neoplasms in cancer patients taking into account the age at first diagnosis, the gender of the patients and the lead time between diagnoses. METHODS: We used standardised incidence ratios (SIRs) to compare the incidence of bladder tumours in 967 767 cancer patients with the incidence rate in the general Swedish population. A total of 3324 male and 1560 female patients developed bladder tumours at least 1 year after first cancer diagnosis. RESULTS: After bladder and renal pelvis cancers, the SIRs of bladder neoplasms were higher in female than in male patients. Men affected by lung, stomach and larynx tumours belonged to the population at high risk for bladder cancer. Treatment of breast, ovarian and cervical cancers seems to contribute to the subsequent development of bladder neoplasms. Long latencies (16 -25 years) were observed after testicular, cervical and endometrial cancers. Detection bias had an important role after prostate cancer. Chemotherapy with cyclophosphamide and cisplatin, and also radiotherapy, seem to increase the risk of subsequent neoplasms in the bladder. CONCLUSIONS: These population-based results may help urologists to assess the risk of bladder neoplasms in cancer survivors. Our data should guide ongoing studies that investigate the effectiveness of bladder cancer screening in cancer patients.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Bladder cancer in cancer patients: population-based estimates from a large Swedish study

Bermejo

Sundquist²,

Hemminki

2009

Br J Cancer

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“…42 (1.31-1.54) 182 3.27 (2.83-3.78) 197 1.20 (1.05-1.38 Admittedly, some of this clustering may be attributable to the well recognized link between the diagnoses of prostate cancer and bladder cancer. [12][13][14] In this study, the overall relative risk for developing prostate cancer as a second primary was 1.83. This elevated incidence is likely attributable to diagnostic efforts which result in the detection of pre-clinical phases of prostate cancer.…”

Section: Discussionmentioning

confidence: 94%

Urothelial Cancer and the Diagnosis of Subsequent Malignancies

Pruthi

Nugent

Czaykowski

et al. 2013

CUAJ

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08-7.04). Overall, the risk was similar between the sexes (female SIR: 1.30, CI 1.09-1.54; males 1.42, CI 1.31-1.54; males excluding prostate SIR: 1.22 CI 1.11-1.35). There was an increased relative risk for developing a second primary for cancers of the kidney (male), lung, breast (female) and prostate. Papillary cancers were associated with increased relative risk of developing lung, prostate, and breast (female and male) cancer. In the competing risks model, patients diagnosed with a papillary or in situ urothelial cancer were more likely to be diagnosed with a second primary than non-papillary and invasive disease, respectively. Conclusions: Those diagnosed with urothelial cancer have an increased probability of having a second primary cancer detected within the subsequent 5 years, even when prostate cancer is excluded. Papillary tumours in particular may provide a warning for subsequent malignancy.

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A population‐based comparison of second primary cancers in Germany and Sweden between 1997 and 2006: clinical implications and etiologic aspects

et al. 2013

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Second primary cancer (SPC) has become an increasing concern in cancer survivorship. Patterns of SPCs in different populations may offer clinical implications and research priorities into SPCs. This study is devoted to compare the occurrences and rank correlations of SPCs between Germany and Sweden. Patients diagnosed with 10 common first primaries between 1997 and 2006 from the Swedish Family-Cancer Database and 10 German cancer registries were included in this population-based study. Spearman's rank correlation coefficients were used to evaluate the strength of the relationship of SPCs between the German and Swedish datasets. Spearman's rank correlation coefficients suggested a strong positive correlation between the German and Swedish datasets based on the ranks of thirty possible SPCs after all selected first cancers. This was also true when we compared the rankings and proportions of the five most common SPCs after site-specific first primaries between the two populations. For kidney cancer, non-Hodgkin's lymphoma, and leukemia the components of the five most common SPCs was exactly the same. Also, the ranking and the proportions for the three most common SPCs (i.e., colorectal, bladder, and lung cancers) after prostate cancer were identical in the two populations, as were those after most other primary cancers. The strikingly consistent patterns of SPCs in the two populations provide excellent opportunities for joint studies and they also suggest that many underlying reasons for SPC may have universal and tangible causes that await mechanistic dissection.The strikingly consistent patterns of second primary cancers (SPCs) in German and Swedish populations provide excellent opportunities for joint studies and they also suggest that many underlying reasons for SPC may have universal and tangible causes that await mechanistic dissection.

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Occurrence of both bladder and prostate cancer in five cancer registries in Belgium, The Netherlands and the United Kingdom

Cited by 31 publications

References 21 publications

Bladder cancer in cancer patients: population-based estimates from a large Swedish study

Bladder cancer in cancer patients: population-based estimates from a large Swedish study

Urothelial Cancer and the Diagnosis of Subsequent Malignancies

A population‐based comparison of second primary cancers in Germany and Sweden between 1997 and 2006: clinical implications and etiologic aspects

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