“…In the environment, soil is the primary receiver of antibiotics used in animal production, mainly through land application of manure (Jechalke et al, 2014). A wide range of antibiotics has been detected worldwide in various manures and manureamended soils, at concentrations up to several thousand mg kg À1 (Martinez-Carballo et al, 2007;Ho et al, 2014;Li et al, 2015;Yang et al, 2016).…”