Occurrence of amyotrophic lateral sclerosis among Gulf War veterans

Horner, Ronnie D.; Kamins, K.G.; Feussner, John R.; Grambow, S.C.; Hoff-Lindquist, J.; Harati, Y.; Mitsumoto, Hiroshi; Pascuzzi, R.; Spencer, Peter S.; Tim, R.; Howard, D.; Smith, T.C.; Ryan, M.A.K.; Coffman, Cynthia J.; Kasarskis, Edward J.

doi:10.1212/01.wnl.0000069922.32557.ca

Cited by 253 publications

(193 citation statements)

References 27 publications

Supporting

Mentioning

183

Contrasting

Unclassified

Order By: Relevance

“…One defined environmental risk is related to occupations, such as military veterans, varsity athletes, and professional football players. [65][66][67] Because these populations share the same risk which distinguished them from other populations, that is, they have increased chance of motor nerve injury, we reasoned that motor nerve injury might trigger the development and/or accelerate the progression of ALS. Therefore, we conducted a study to determine the immune responses after nerve injury in mouse ALS model.…”

Section: Th17 Cells Nerve Injury and Alsmentioning

confidence: 99%

How are necroptosis, immune dysfunction, and motoneuron death connected in amyotrophic lateral sclerosis?

Liu¹,

Zheng²,

Xin³

et al. 2017

View full text Add to dashboard Cite

How to cite this article: Liu JF, Zheng OX, Xin JG, Chen HH, Xin JJ. How are necroptosis, immune dysfunction, and motoneuron death connected in amyotrophic lateral sclerosis ? Neuroimmunol Neuroinflammation 2017;4:109-16. Abnormal immune response/inflammation is present in patients of amyotrophic lateral sclerosis (ALS). Autoimmune-related inflammation has been thought to be involved in the pathogenesis of ALS. However, how the abnormal immune responses are initiated, what specific immune cells and how these immune cells are involved in this disease have not been well understood. This is partly owing to two facts of ALS: late diagnosis and chronic nature. The late diagnosis makes it difficult to conclude whether the abnormal immune responses/inflammation is the cause or result of the disease. The chronic nature makes it difficult to determine the best timing for the detection of such autoimmune responses. To resolve these two challenges for research, the authors introduced motor nerve injury (facial nerve axotomy, FNA) into a pre-symptomatic mouse ALS model (8-week-old SOD1 G93A mice), which induces a readily detectable immune response in a predictable time period (3-14 days). The authors found that pre-symptomatic SOD1 G93A mice showed a higher basal level of T cell activation and Th17 cells than WT mice, which can be further increased by FNA. However, why these pro-inflammatory Th lymphocyte MinireviewThis is an open access article distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

show abstract

Section: Th17 Cells Nerve Injury and Alsmentioning

confidence: 99%

How are necroptosis, immune dysfunction, and motoneuron death connected in amyotrophic lateral sclerosis?

Liu¹,

Zheng²,

Xin³

et al. 2017

View full text Add to dashboard Cite

show abstract

“…PON2 and PON3 share this function (Draganov et al, 2000;Ng et al, 2001). A higher incidence of ALS among Gulf war veterans and farmers suggested that chemical exposure may be a risk factor for ALS (Chió et al, 1991;Horner et al, 2003). Because PON proteins reduce oxidation and are able to detoxify neurotoxins these proteins have been investigated for association with ALS.…”

Section: Paraoxonase Genes (Pon)mentioning

confidence: 99%

Genetics of Amyotrophic Lateral Sclerosis

Devil

Andersen

Bosch

et al. 2012

Amyotrophic Lateral Sclerosis

View full text Add to dashboard Cite

“…Environmental exposures during the Gulf war have been proposed as the explanation for an increased incidence of ALS among Gulf War veterans (Haley 2003, Horner et al, 2003.…”

Section: Aetiology Pathology and Pathogenesis Of Motor Neuron Diseasementioning

confidence: 99%

Motor Neuron Disease

Tallawy¹

2012

Neuromuscular Disorders

View full text Add to dashboard Cite

Occurrence of amyotrophic lateral sclerosis among Gulf War veterans

Abstract: Military personnel who were deployed to the Gulf Region during the Gulf War period experienced a greater post-war risk of ALS than those who were not deployed to the Gulf.

Cited by 253 publications

References 27 publications

How are necroptosis, immune dysfunction, and motoneuron death connected in amyotrophic lateral sclerosis?

How are necroptosis, immune dysfunction, and motoneuron death connected in amyotrophic lateral sclerosis?

Genetics of Amyotrophic Lateral Sclerosis

Motor Neuron Disease

Contact Info

Product

Resources

About