Occurrence, fate and toxic effects of the industrial endocrine disrupter, nonylphenol, on plants - A review

Bruin, Willeke de; Kritzinger, Quenton; Bornman, Riana; Korsten, Lisé

doi:10.1016/j.ecoenv.2019.06.009

Cited by 48 publications

(16 citation statements)

References 95 publications

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“…The concentration of BPA (0.5 mg/kg) chosen for this study was based on previous toxicological studies, 9,[22][23][24] the no observable adverse effect level (NOAEL) 9,22 and environmental concentrations. 25,26 The NP exposure rat model used herein was according to the NOAEL, 22,27 environmental concentration ranges in aquatic systems, 25,28 and previous studies that reported a toxic effect on the testis at doses starting from 5 mg/kg of NP. 20,22,[29][30][31][32]…”

Section: -Nonylphenol Bisphenol a Ftir Spectroscopy Leydig Cells Mult...mentioning

confidence: 99%

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Xia

Guo

et al. 2022

Environmental Toxicology

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Bisphenol A (BPA) and 4-nonylphenol (NP) are well-known endocrine-disrupting chemicals (EDCs) that have been proven to affect Leydig cell (LC) functions and testosterone production, but whether BPA and NP have multi-and transgenerational biochemical effects on Leydig cells (LCs) is unknown. Fourier transform infrared (FTIR) spectroscopy is a powerful analytical technique that enables label-free and non-destructive analysis of the tissue specimen. Herein we employed FTIR coupled with chemometrics analysis to identify biomolecular changes in testicular interstitial (Leydig) cells of rats after chronic exposure to low doses of BPA and NP. Cluster segregations between exposed and control groups were observed based on the fingerprint region of 1800-900 cm À1 in all generations. The main biochemical alterations for segregation were amide I, amide II and nucleic acids. BPA and NP single and coexposure induced significant differences in the ratio of amide I to amide II compared to the corresponding control group in all generations. BPA exposure resulted in remarkable changes of cellular gene transcription and DNA oxidative damage across all generations. Direct exposure to BPA, NP, and BPA&NP of F0 and F1 generations could significantly decrease lipid accumulation in LCs in the F2 and F3 generations.The overall findings revealed that single or co-exposure to BPA and NP at environmental concentrations affects the biochemical structures and properties of LCs.

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Section: -Nonylphenol Bisphenol a Ftir Spectroscopy Leydig Cells Mult...mentioning

confidence: 99%

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Xia

Guo

et al. 2022

Environmental Toxicology

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“…6 Currently, investigating the occurrence, fate, and potential ecological risks of NPs in the aquatic, terrestrial, and atmospheric environments is urgent. 1,[3][4][5] Due to the nonyl chain, NPs have hydrophobic properties. 4 The highly hydrophobic NPs pose a strong intendancy to interaction with soil/sediment organic matter, especially the ubiquitous dissolved organic matter (DOM), which signicantly inuence the transportation, transformation, and bioavailability of NPs in the environments.…”

Section: Introductionmentioning

confidence: 99%

Insight into the hetero-interactions of 4-nonylphenol with dissolved organic matter: multiple spectroscopic methods, ¹H NMR study and principal component analysis

et al. 2022

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“…NPEs are readily biodegradable due to the presence of ethoxy groups. The stepwise loss of these groups during the degradation process leads to the formation of nonylphenol (NP) (De Bruin et al, 2019;Li, Jin & Snyder, 2018). Anaerobic conditions are favored for NP formation; however, some studies have indicated that oxic conditions can also drive the reaction (Careghini et al, 2015;Micic & Hofmann, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…The first-order half-life of NP isomers could be >200 days under strongly reduced conditions (Careghini et al, 2015). Hence, NP is a relatively stable chemical and accumulate in different environmental matrices including ground and surface waters, drinking waters, soils, sediments, atmosphere and air (Careghini et al, 2015;De Bruin et al, 2019;Forte et al, 2016;Yang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic analysis of nonylphenol effect on Saccharomyces cerevisiae

Bereketoğlu

Nacar

Sari

et al. 2021

PeerJ

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Nonylphenol (NP) is a bioaccumulative environmental estrogen that is widely used as a nonionic surfactant. We have previously examined short-term effects of NP on yeast cells using microarray technology. In the present study, we investigated the adaptive response of Saccharomyces cerevisiae BY4742 cells to NP exposure by analyzing genome-wide transcriptional profiles using RNA-sequencing. We used 2 mg/L NP concentration for 40 days of exposure. Gene expression analysis showed that a total of 948 genes were differentially expressed. Of these, 834 genes were downregulated, while 114 genes were significantly upregulated. GO enrichment analysis revealed that 369 GO terms were significantly affected by NP exposure. Further analysis showed that many of the differentially expressed genes were associated with oxidative phosphorylation, iron and copper acquisition, autophagy, pleiotropic drug resistance and cell cycle progression related processes such as DNA and mismatch repair, chromosome segregation, spindle checkpoint activity, and kinetochore organization. Overall, these results provide considerable information and a comprehensive understanding of the adaptive response to NP exposure at the gene expression level.

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Occurrence, fate and toxic effects of the industrial endocrine disrupter, nonylphenol, on plants - A review

Cited by 48 publications

References 95 publications

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Insight into the hetero-interactions of 4-nonylphenol with dissolved organic matter: multiple spectroscopic methods, ¹H NMR study and principal component analysis

Transcriptomic analysis of nonylphenol effect on Saccharomyces cerevisiae

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Occurrence, fate and toxic effects of the industrial endocrine disrupter, nonylphenol, on plants - A review

Cited by 48 publications

References 95 publications

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Insight into the hetero-interactions of 4-nonylphenol with dissolved organic matter: multiple spectroscopic methods, 1H NMR study and principal component analysis

Transcriptomic analysis of nonylphenol effect on Saccharomyces cerevisiae

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Product

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Insight into the hetero-interactions of 4-nonylphenol with dissolved organic matter: multiple spectroscopic methods, ¹H NMR study and principal component analysis