Occurrence, Biosynthesis, Biological activity and NMR Spectroscopy of D and B, D Ring Seco-limonoids of Meliaceae Family

Narender, Tadigoppula; Khaliq, Tanvir; Shweta, .; Reddy, K. Papi; Sharma, Ravi

doi:10.1177/1934578x0700200219

Cited by 10 publications

(9 citation statements)

References 91 publications

(141 reference statements)

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“…Meliaceae trees are known as an excellent hardwood, prized for their wood quality, besides having considerable economic value, for example, cedar ( Cedrela ) and mahogany ( Swietenia spp., Khaya spp.) [ 4 , 5 ]. As a result, plants of this genus have experienced overexploitation, leading to three species being added to the Official National List of Flora Species Endangered by Decree No.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

et al. 2020

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The genus Cedrela P. Browne, which belongs to the Meliaceae family, has eighteen species. Trees of this genus are of economic interest due to wood quality, as well as being the focus of studies because of relevant biologic activities as in other Meliaceae species. These activities are mainly related to limonoids, a characteristic class of compounds in this family. Therefore, the aim of this review is to perform a survey of the citations in the literature on the Cedrela genus species. Articles were found on quantitative and qualitative phytochemical studies of the Cedrela species, revealing the chemical compounds identified, such as aliphatics acid and alcohol, flavonoids, tocopherol, monoterpenes, sesquiterpenes, triterpenes, cycloartanes, steroids, and limonoids. Although some activities were tested, the majority of studies focused on the insecticidal, antifeedant, or insect growth inhibitor activities of this genus. Nonetheless, the most promising activities were related to their antimalarial and antitripanocidal effects, although further investigations are still needed.

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Section: Introductionmentioning

confidence: 99%

“…Overall, the following biological activities are described for the Meliaceae family, which are reported for the genus Cedrela [ 17 ]: antiviral, anthelmintic, anti-rheumatic, anti-cancer, and anti-inflammatory action, and antifeedant and insecticidal effects [ 4 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

et al. 2020

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“…Khaya senegalensis extracts have been reported to exhibit anti-inflammatory effects [ 4 ] as well as anti-bacterial [ 5 ], antihelmintic [ 6 ], antitumor, antioxidant [ 7 ] and antiplasmodial activities [ 8 ]. The stem bark extract and the chemical constituent profile have been the subject of extensive phytochemical and pharmacological investigations since the 1960s [ 9 – 11 ]. Despite the extensive research on the stem bark extract of Khaya senegalensis , a dearth of information on the toxicological profile of this plant still exists.…”

Section: Introductionmentioning

confidence: 99%

Effect of Aqueous Stem Bark Extract ofKhaya senegalensison Some Biochemical, Haematological, and Histopathological Parameters of Rats

Onu

Saidu

Ladan

et al. 2013

Journal of Toxicology

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The subchronic effect of aqueous stem bark extract of Khaya senegalensis on some biochemical, haematological, and histopathological parameters of rats was investigated. The rats were divided into six groups of five rats per group. Groups I to VI were administered graded doses of 0, 400, 800, 1200, 1600, and 2000 mg/kg bw, respectively. The result of study revealed that administration of the Khaya senegalensis for twenty-eight days at the experimental dose resulted in significant (P < 0.05) increase in urea, electrolytes (Na+, K+), and creatinine levels. The extract also significantly (P < 0.05) increased serum activity of ALT, AST, and ALP. The levels of protein, albumin, and bilirubin were significantly changed when compared to their control values, but they were not dose dependent. The hematological indices assayed in this study were not significantly affected at the experimental dose when compared to the control values. Histological studies of the liver showed cellular degeneration and necrosis and bile duct hyperplasia and fibrosis with lymphocytic infiltration of the hepatocyte, providing supportive evidence for discussing the biochemical findings, indicative of functional derangement. The histological architecture of the kidney and that of the heart were however preserved. The result of this study indicates that the aqueous stem bark extract of K. senegalensis may affect the cellular integrity of vital organs of the body.

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“…Ethanol extract of X. granatum fruit from Hainan Island contained 3-deacetyl xyloccensin M ( 5 ) with a molecular formula of C 27 H 36 O 8 . Compound 5 has six rings, two esters, and carbon–carbon double bonds, and it has a similar structure to xyloccensin M. Another isolated compound, 3-deacetyl xyloccensin N ( 6 ) with a molecular formula, C 27 H 36 O 8 , has keto and ester carbonyl groups, hydroxyl, carbon double bond, one methoxycarbonyl group, and β -furyl moiety [ 87 ]. Compounds 5 and 6 are a pair of isomers of mexicanolides, and compound 6 is suspected as a biosynthetic intermediate of compound 5 [ 72 ].…”

Section: Secondary Metabolites Isolated From Mangrove Fruitmentioning

confidence: 99%

Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East

et al. 2022

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Nowadays, the logarithmic production of existing well-known food materials is unable to keep up with the demand caused by the exponential growth of the human population in terms of the equality of access to food materials. Famous local food materials with treasury properties such as mangrove fruits are an excellent source to be listed as emerging food candidates with ethnomedicinal properties. Thus, this study reviews the nutrition content of several edible mangrove fruits and the innovation to improve the fruit into a highly economic food product. Within the mangrove fruit, the levels of primary metabolites such as carbohydrates, protein, and fat are acceptable for daily intake. The mangrove fruits, seeds, and endophytic fungi are rich in phenolic compounds, limonoids, and their derivatives as the compounds present a multitude of bioactivities such as antimicrobial, anticancer, and antioxidant. In the intermediary process, the flour of mangrove fruit stands as a supplementation for the existing flour with antidiabetic or antioxidant properties. The mangrove fruit is successfully transformed into many processed food products. However, limited fruits from species such as Bruguiera gymnorrhiza, Rhizophora mucronata, Sonneratia caseolaris, and Avicennia marina are commonly upgraded into traditional food, though many more species demonstrate ethnomedicinal properties. In the Middle East, A. marina is the dominant species, and the study of the phytochemicals and fruit development is limited. Therefore, studies on the development of mangrove fruits to functional for other mangrove species are demanding. The locally accepted mangrove fruit is coveted as an alternate food material to support the sustainable development goal of eliminating world hunger in sustainable ways.

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Occurrence, Biosynthesis, Biological activity and NMR Spectroscopy of D and B, D Ring Seco-limonoids of Meliaceae Family

Cited by 10 publications

References 91 publications

Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

Effect of Aqueous Stem Bark Extract ofKhaya senegalensison Some Biochemical, Haematological, and Histopathological Parameters of Rats

Exploring the Mangrove Fruit: From the Phytochemicals to Functional Food Development and the Current Progress in the Middle East

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