Occurrence and Risks of Contrast Agents, Cytostatics, and Antibiotics in Hospital Effluents

Escudero-Oñate, Carlos; Ferrando-Climent, Laura; Rodríguez-Mozaz, Sara; Santos, Lúcia H.M.L.M.

doi:10.1007/698_2017_12

Cited by 9 publications

(7 citation statements)

References 101 publications

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“…Here we show that intI1 and aint1 dominated all compartments in our wastewater network, with intI2 and intI3 being much less abundant at all sampling points. All integron markers, except for empty structures (eaint1), were highest in hospital wastewater where antibiotic use is more intensive (Escudero-Oñate et al, 2017;Rodriguez-Mozaz et al, 2015). This is consistent with previous data that showed the relative number of ARGs per bacterial cell were at least one order of magnitude higher in hospital wastewater compared with the other compartments (Quintela-Baluja et al, 2019).…”

Section: Discussionsupporting

confidence: 91%

Dynamics of integron structures across a wastewater network – Implications to resistance gene transfer

et al. 2021

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Section: Discussionsupporting

confidence: 91%

Dynamics of integron structures across a wastewater network – Implications to resistance gene transfer

et al. 2021

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“…Studying a network with two hospitals is important because antibiotic use is more intensive in hospital settings, especially last resort antibiotics, selecting for AR bacteria (ARB) over susceptible counterparts (Stalder et al., 2014; Rodriguez-Mozaz et al . 2015; Escudero-Onate et al., 2017; Rowe et al . 2017; Szekeres et al .…”

Section: Introductionmentioning

confidence: 99%

Spatial ecology of a wastewater network defines the antibiotic resistance genes in downstream receiving waters

et al. 2019

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Wastewater treatment plants (WWTPs) are an effective barrier in the protection of human and environment health around the world, although WWTPs also are suggested to be selectors and-or reservoirs of antibiotic resistance genes (ARGs) before entering the environment. The dogma about WWTPs as “ARG selectors” presumes that biotreatment compartments (e.g., activated sludge; AS) are single densely populated ecosystems with elevated horizontal gene transfer. However, recent work has suggested WWTP biotreatment compartments may be different than previously believed relative to antibiotic resistance (AR) fate, and other process factors, such as bacterial separation and specific waste sources, may be key to ARGs released to the environment. Here we combined 16S rRNA metagenomic sequencing and high-throughput qPCR to characterise microbial communities and ARGs across a wastewater network in Spain that includes both community (i.e., non-clinical urban) and hospital sources. Contrary to expectations, ARGs found in downstream receiving waters were not dominated by AS biosolids (RAS), but more resembled raw wastewater sources. In fact, ARGs and microbial communities in liquid-phase WWTP effluents and RAS were significantly different (Bray–Curtis dissimilarity index = 0.66 ± 0.11), with a consequential fraction of influent ARGs and organisms passing directly through the WWTP with limited association with RAS. Instead, ARGs and organisms in the RAS may be more defined by biosolids separation and biophysical traits, such as flocculation, rather than ARG carriage. This explains why RAS has significantly lower ARG richness (47 ± 4 ARGs) than liquid-phase effluents (104 ± 5 ARGs), and downstream water column (135 ± 4 ARGs) and river sediments (120 ± 5 ARGs) (Tukey's test, p < 0.001). These data suggest RAS and liquid-phase WWTP effluents may reflect two parallel ecosystems with potentially limited ARG exchange. As such, ARG mitigation in WWTPs should more focus on removing bacterial hosts from the liquid phase, AR source reduction, and possibly disinfection to reduce ARG releases to the environment.

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“…However, the removal efficiency of micropollutants (including antibiotics, antimicrobial resistance bacteria, and antimicrobial resistance genes) originating from hospital wastewater is relatively poor (i.e., partially or not eliminated at all) [ 11 ]. A threat to environmental and human health could be found when the partially-treated effluents reach the aquatic environment [ 11 , 63 ]. This contributes to the spreading of resistant bacteria that can be ultimately transferred as pathogens to humans, animals, and fish [ 63 , 64 ] and develop nosocomial infections.…”

Section: Potential Limitation Of Conventional Techniquesmentioning

confidence: 99%

Post-treatment disinfection technologies for sustainable removal of antibiotic residues and antimicrobial resistance bacteria from hospital wastewater

Werkneh¹,

Islam²

2023

Heliyon

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Occurrence and Risks of Contrast Agents, Cytostatics, and Antibiotics in Hospital Effluents

Cited by 9 publications

References 101 publications

Dynamics of integron structures across a wastewater network – Implications to resistance gene transfer

Dynamics of integron structures across a wastewater network – Implications to resistance gene transfer

Spatial ecology of a wastewater network defines the antibiotic resistance genes in downstream receiving waters

Post-treatment disinfection technologies for sustainable removal of antibiotic residues and antimicrobial resistance bacteria from hospital wastewater

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