A major tributary of the Yarlung Tsangpo River on the
Tibetan Plateau,
the Lhasa River, flows through Lhasa, one of the world’s highest-altitude
cities. Along with the fast urbanization and booming tourism industry
in Lhasa, pollution of its aquatic environment receives growing concerns.
This study quantified the spatiotemporal distributions and potential
ecological risk of common antimicrobials in the lower reach of the
Lhasa River for the first time and found untreated domestic wastewater
to be a key source of pollution. Thirty-four antimicrobials were detected,
with concentrations spanning 4 orders of magnitude (0.01–629
ng/L). Spatial variations of antimicrobials were observed, with tetracyclines
and macrolides dominated at the upstream and downstream sites of Lhasa
city, respectively, due to varying source inputs and different attenuation
of
antimicrobials. Although only a few antimicrobials pose medium–high
ecological risk individually, the simultaneous occurrence of multiple
antimicrobials may result in significant ecological toxicity. While
the treated wastewater effluent and agricultural runoff combined contributed
to 14.2 and 23.5% of the total antimicrobials in the Lhasa River during
wet and dry seasons, respectively, the untreated domestic wastewater
discharge accounted for the rest. These findings indicate the urgent
need for improving the collection system and treatment technology
of domestic wastewater in Lhasa.