Occurrence and removal of progestagens in municipal wastewater treatment plants from different regions in China

Yu, Qingmiao; Geng, Jinju; Zong, Xueying; Xu, Ke; Hu, Haidong; Deng, Yongfeng; Zhao, Fugeng; Ren, Hongqiang

doi:10.1016/j.scitotenv.2019.02.327

Cited by 39 publications

(13 citation statements)

References 46 publications

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“…Slow transformation of DIE is consistent with observations in WWTP effluents where DIE was the most frequently detected among 18 progestins. , DRO was degraded rapidly over the first 7 h with t 1/2 < 0.5 h (50 ± 3% spiked mass recovered at t 0 ); then, concentration loss plateaued (0.12 ± 0.03 μg/L) at over 7–72 h. This was consistent with the <0.02 h half-life previously reported for DRO . Although rapid transformation suggests reduced probability of detection, DRO was detected in WWTP effluents from the Czech Republic, Hungary, and China. ,, This aligns with high DRO use in these regions as one of the most consumed synthetic progestins and may also indicate that some fraction of DRO exhibited limited bioavailability for transformation within WWTPs.…”

Section: Results and Discussionsupporting

confidence: 90%

“…17 Although rapid transformation suggests reduced probability of detection, DRO was detected in WWTP effluents from the Czech Republic, Hungary, and China. 18,22,23 This aligns with high DRO use in these regions as one of the most consumed synthetic progestins 18 and may also indicate that some fraction of DRO exhibited limited bioavailability for transformation within WWTPs.…”

Section: ■ Results and Discussionmentioning

confidence: 64%

“…20 Consistent with usage, DIE was the most frequently detected synthetic progestin in wastewater and surface water in Germany (effluent, 1.3−4.4 ng/L; surface water, <0.05−2.3 ng/L) 21 and the Czech Republic (influent, 1.9−11 ng/L; effluent, <0.05−1.0 ng/L; surface water, <0.09 ng/L). 18 DRO was detected in wastewater in the Czech Republic (influent, 0.64 ng/L; effluent, 0.29 ng/L), 18 in China (influent, 0.69 ng/L; effluent, 0.39 ng/L), 22 and in surface water (0.26−4.30 ng/L) from Hungary. 23 Chronic exposure (160 days) to 2 ng/L DRO lowered fshβ mRNA levels (follicle-stimulating hormone encoding gene) in the pituitary of common carp and increased macrovacuoles in hepatocytes.…”

Section: ■ Introductionmentioning

confidence: 99%

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Biotransformation of Current-Use Progestin Dienogest and Drospirenone in Laboratory-Scale Activated Sludge Systems Forms High-Yield Products with Altered Endocrine Activity

Zhao

Tian

Kim

et al. 2021

Environ. Sci. Technol.

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Dienogest (DIE) and drospirenone (DRO) are two fourth-generation synthetic progestins widely used as oral contraceptives. Despite their increasing detection in wastewaters and surface waters, their fate during biological wastewater treatment is unclear. Here, we investigated DIE and DRO biotransformation with representative activated sludge batch incubations and identified relevant transformation products (TPs) using high-resolution mass spectrometry. DIE exhibited slow biotransformation (16−30 h half-life) and proceeded through a quantitative aromatic dehydrogenation to form TP 309 (molar yields of ∼55%), an aromatic TP ∼30% estrogenic as 17βestradiol. DRO experienced more rapid biotransformation (<0.5 h half-life), and 1,2-dehydrogenation formed the major TP 364 (molar yields of ∼40%), an antimineralocorticoid drug candidate named as spirorenone. Lactone ring hydrolysis was another important biotransformation pathway for DRO (molar yields of ∼20%) and generated pharmacologically inactive TP 384. Other minor pathways for DIE and DRO included hydroxylation, methoxylation, and 3-keto and C4(5) double-bond hydrogenation; distinct bioactivities are plausible for such TPs, including antigestagenic activity, antigonadotropic activity, and pregnancy inhibition effects. Thus, biotransformation products of DIE and DRO during wastewater treatment should be considered in environmental assessments of synthetic progestins, especially certain TPs such as the estrogenic TP 309 of DIE and the antimineralocorticoid spirorenone (TP 364) of DRO.

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Section: Results and Discussionsupporting

confidence: 90%

Section: ■ Results and Discussionmentioning

confidence: 64%

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biotransformation of Current-Use Progestin Dienogest and Drospirenone in Laboratory-Scale Activated Sludge Systems Forms High-Yield Products with Altered Endocrine Activity

Zhao

Tian

Kim

et al. 2021

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…It was observed that CECs such as genistein or progesterone were completely removed in the secondary treatment, in line with what was observed by Gros et al [58], due to removal mechanisms based on adsorption and biodegradation. According to the study by Yu et al [59], of the two possible pathways, biodegradation under aerobic conditions would be the main pathway removing both compounds.…”

Section: Removal Yields Of Cecs In the C-uf Pilot Plantmentioning

confidence: 99%

Water Reuse Study from Urban WWTPs via c-Ultrafiltration and Ozonation Technologies: Basis for Resilient Cities and Agriculture

et al. 2021

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The water–development nexus is essential for the advancement and progress of cities in the face of problems such as climate change, water security and increasing environmental stress in the agricultural sector. Aiming for a circular economy and, at the same time, improving the resilience of water supply alternatives and achieving a goal of zero waste, this work presents a technical–economic study of a novel continuous ultrafiltration (c-UF) system with self-cleaning capacity coupled to an ozonation process, for the treatment of urban WWTP effluent. The removal efficiencies achieved were analysed both through macroscopic parameters (suspended solids, turbidity) and for the most frequently occurring contaminants of emerging concern (CECs). Consequently, an effluent suitable for irrigation was obtained, with a total recovery factor of 97.92%, a concentration of suspended solids (SS) below 1 mg L−1, 0.06 NTU turbidity and toxicity free, complying with the new European Regulation on Water Reuse (EU 2020/741). A comparative analysis of the proposed process with regard to conventional tertiary treatment revealed that the proposed process was 39.1% more economic, with a cost of 0.0325 € m−3. This alternative treatment will be of great interest because of its favourable technical–economic characteristics, being postulated as a basic process for implementation in modern water reuse plants.

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“…Once a large amount of P4 remaining in industrial production wastewater is discharged into the environment, it will pose a great threat to animal and human health. (Kumar et al 2015, Yu et al 2019). However, it is still a challenge to effectively detect and enrich the residual P4 in the industrial wastewater due to the complex substrate, many interfering coexisting substances and wide range of pH values.…”

Section: Introductionmentioning

confidence: 99%

Methacrylic functionalized hybrid carbon nanomaterial for the selective adsorption and detection of progesterone in wastewater

Cui

Shu

Wang

et al. 2021

Environ Sci Pollut Res

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Progesterone, an endocrine-disrupting chemical, has been frequently detected in wastewater for decades, posing a serious threat to ecological and human health. However, it is still a challenge to achieve the effective detection of progesterone in complex matrices water samples. In this study, a novel adsorbent CNT@CS/P(MAA) was prepared by grafting methacrylic polymers on the surface of modified carbon nanomaterials. Compared with other reported materials, the hybrid carbon nanomaterial could selectively identify the progesterone in the complex industrial pharmaceutical wastewater, and its adsorption performance is almost independent of pH and environmental temperature. In addition, this nanomaterial could be reused with a good recovery rate. The prepared nanomaterials were characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, nitrogen adsorption and desorption experiments and thermo gravimetric analysis. The results confirmed that the methacrylic polymers and chitosan layer were successfully grafted on the surface of carbon nanotubes. Adsorption isotherms, adsorption kinetics, and selectivity tests showed that CNT@CS/P(MAA) had a high adsorption capacity (44.45 mg•g -1 ), a fast adsorption rate and a satisfied selectivity for progesterone. Then, CNT@CS/P(MAA) was used as solid phase extraction sorbent and combined with HPLC to enrich progesterone from the wastewater samples. Under the optimum conditions, a good linearity was obtained with the correlation coefficient was 0.9998, and the limit of detection was 0.003 ng•mL -1 . Therefore, this method could be used for the selective and effective detection of progesterone in the industrial wastewater with complex substrates, and provided a new method for the detection of progesterone in other environmental waters.

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Occurrence and removal of progestagens in municipal wastewater treatment plants from different regions in China

Cited by 39 publications

References 46 publications

Biotransformation of Current-Use Progestin Dienogest and Drospirenone in Laboratory-Scale Activated Sludge Systems Forms High-Yield Products with Altered Endocrine Activity

Biotransformation of Current-Use Progestin Dienogest and Drospirenone in Laboratory-Scale Activated Sludge Systems Forms High-Yield Products with Altered Endocrine Activity

Water Reuse Study from Urban WWTPs via c-Ultrafiltration and Ozonation Technologies: Basis for Resilient Cities and Agriculture

Methacrylic functionalized hybrid carbon nanomaterial for the selective adsorption and detection of progesterone in wastewater

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