Occurrence and removal of PPCPs from on-site wastewater using nitrogen removing biofilters

Clyde, Patricia M.; Lee, Cheng‐Shiuan; Price, Roy E.; Venkatesan, Arjun K.; Brownawell, Bruce J.

doi:10.1016/j.watres.2021.117743

Cited by 22 publications

(1 citation statement)

References 65 publications

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“…A list of all compounds used in this study is presented in Table S1 . The 26 pharmaceuticals, including OTC drugs and the metabolites, were chosen because of their relatively high prescriptions per population in the U.S. and high environmental detection frequencies in previous studies [ 38 , 39 ].…”

Section: Methodsmentioning

confidence: 99%

Monitoring of over-the-counter (OTC) and COVID-19 treatment drugs complement wastewater surveillance of SARS-CoV-2

Lee,

Wang,

Nanjappa

et al. 2023

J Expo Sci Environ Epidemiol

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Background The application of wastewater-based epidemiology to track the outbreak and prevalence of coronavirus disease (COVID-19) in communities has been tested and validated by several researchers across the globe. However, the RNA-based surveillance has its inherent limitations and uncertainties. Objective This study aims to complement the ongoing wastewater surveillance efforts by analyzing other chemical biomarkers in wastewater to help assess community response (hospitalization and treatment) during the pandemic (2020–2021). Methods Wastewater samples (n = 183) were collected from the largest wastewater treatment facility in Suffolk County, NY, USA and analyzed for COVID-19 treatment drugs (remdesivir, chloroquine, and hydroxychloroquine (HCQ)) and their human metabolites. We additionally monitored 26 pharmaceuticals including common over-the-counter (OTC) drugs. Lastly, we developed a Bayesian model that uses viral RNA, COVID-19 treatment drugs, and pharmaceuticals data to predict the confirmed COVID-19 cases within the catchment area. Results The viral RNA levels in wastewater tracked the actual COVID-19 case numbers well as expected. COVID-19 treatment drugs were detected with varying frequency (9–100%) partly due to their instability in wastewater. We observed a significant correlation (R = 0.30, p < 0.01) between the SARS-CoV-2 genes and desethylhydroxychloroquine (DHCQ, metabolite of HCQ). Remdesivir levels peaked immediately after the Emergency Use Authorization approved by the FDA. Although, 13 out of 26 pharmaceuticals assessed were consistently detected (DF = 100%, n = 111), only acetaminophen was significantly correlated with viral loads, especially when the Omicron variant was dominant. The Bayesian models were capable of reproducing the temporal trend of the confirmed cases. Impact In this study, for the first time, we measured COVID-19 treatment and pharmaceutical drugs and their metabolites in wastewater to complement ongoing COVID-19 viral RNA surveillance efforts. Our results highlighted that, although the COVID-19 treatment drugs were not very stable in wastewater, their detection matched with usage trends in the community. Acetaminophen, an OTC drug, was significantly correlated with viral loads and confirmed cases, especially when the Omicron variant was dominant. A Bayesian model was developed which could predict COVID-19 cases more accurately when incorporating other drugs data along with viral RNA levels in wastewater.

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Section: Methodsmentioning

confidence: 99%

Monitoring of over-the-counter (OTC) and COVID-19 treatment drugs complement wastewater surveillance of SARS-CoV-2

Lee,

Wang,

Nanjappa

et al. 2023

J Expo Sci Environ Epidemiol

Self Cite

View full text Add to dashboard Cite

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Pharmaceutical emerging micropollutants potential in septic tanks: Its fate and transport study in Indonesia – A literature review

Wardhani,

Soedjono,

Titah

et al. 2024

Environmental Quality Mgmt

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Micropollutants also known as “emerging micropollutants” (EMPs) have gained significant attention in research, with a particular emphasis on the ocean, marine water, and river pollution. The interest arises from the impact of EMPs on aquatic ecosystems, often originating from sources such as wastewater treatment plant (WWTP) and septic tanks leakage. However, EMPs pollution in surface water can also be caused by leakage of septic tanks. In Indonesia, where septic tanks maintenance is generally neglected, there is a potential risk of EMPs contamination. The outcome and transformation of EMPs, as well as their potential transport pathways, are influenced by sanitary conditions and the effectiveness of existing septic tanks. This concern has escalated to the point of causing fecal contamination in drinking water sources. Therefore, this research focuses on EMPs, specifically pharmaceutical EMPs, leakage from septic tanks, and their possible fate and transport. It also discusses related perspectives of previous research related to EMPs contamination due to leakage of septic tanks.

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Optimization of Dual-Chamber Microbial Fuel Cells for the Biodegradation of Acetaminophen

Asetre¹,

Tayo²

2023

Environmental Science and Engineering

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Occurrence and removal of PPCPs from on-site wastewater using nitrogen removing biofilters

Cited by 22 publications

References 65 publications

Monitoring of over-the-counter (OTC) and COVID-19 treatment drugs complement wastewater surveillance of SARS-CoV-2

Monitoring of over-the-counter (OTC) and COVID-19 treatment drugs complement wastewater surveillance of SARS-CoV-2

Pharmaceutical emerging micropollutants potential in septic tanks: Its fate and transport study in Indonesia – A literature review

Optimization of Dual-Chamber Microbial Fuel Cells for the Biodegradation of Acetaminophen

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