Occurrence and Removal of Antibiotics, Antibiotic-Resistance Genes and Bacterial Communities in Hospital Wastewater

Yao, Shijie; Ye, Jianfeng; Yang, Qiao; Hu, Yaru; Zhang, Tianyang; Jiang, Lei; Munezero, Salvator; Lin, Kuangfei; Cui, Changzheng

doi:10.21203/rs.3.rs-192739/v1

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…To date, numerous experiments and studies have been conducted to uncover the presence and abundance of ARGs in media as landfills, industrial and medical wastewater, and livestock farms and soils ( 15 ). Soil is one of the habitats with the highest microbial diversity on earth, a source of natural antibiotics, and a repository of ARGs ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

The Formation of Antibiotic Resistance Genes in Bacterial Communities During Garlic Powder Processing

Liu

Gao

et al. 2021

Front. Nutr.

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Chinese garlic powder (GP) is exported to all countries in the world, but the excess of microorganisms is a serious problem that affects export. The number of microorganisms has a serious impact on the pricing of GP. It is very important to detect and control the microorganism in GP. The purpose of this study was to investigate the contamination and drug resistance of microorganisms during the processing of GP. We used metagenomics and Illumina sequencing to study the composition and dynamic distribution of antibiotic resistance genes (ARGs), but also the microbial community in three kinds of garlic products from factory processing. The results showed that a total of 126 ARG genes were detected in all the samples, which belonged to 11 ARG species. With the processing of GP, the expression of ARGs showed a trend to increase at first and then to decrease. Network analysis was used to study the co-occurrence patterns among ARG subtypes and bacterial communities and ARGs.

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Section: Introductionmentioning

confidence: 99%

The Formation of Antibiotic Resistance Genes in Bacterial Communities During Garlic Powder Processing

Liu

Gao

et al. 2021

Front. Nutr.

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A Sustainable Method to Reduce Vancomycin Concentrations in Water Using Timber Waste

Delmond¹,

Tretsiakova-McNally²,

Solan³

et al. 2023

Water Air Soil Pollut

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Emerging contaminants are becoming a significant challenge for modern society. Antibiotic resistance is notably among the most urgent public health concerns, and it is well recognised that the problem often originates from wastewater treatment facilities. In developed countries, where affordable and specified, activated carbon can be used as an efficient adsorbent of antibiotic residues present in wastewaters. However, this method is associated with high production and reactivation costs and has a significant carbon footprint. Research at Ulster University proposes a more sustainable and cost-effective solution to this problem. The technique involves the application of modified sawdust waste to treated effluent, reducing tertiary antibiotic contamination. The sawdust used in the current study was from two sources: ash or a mixture of tree species. These materials, in unmodified and modified forms, were applied as the adsorbents in model systems containing vancomycin (antibiotic) dissolved in distilled water at concentrations ranging between 30 and 150 mg/L. It was found that such adsorbents are highly efficient at removing vancomycin from contaminated waters. Antibiotic removal levels reached 63.0% (σ = 2.3%) for the modified mixed sawdust and 56.6% (σ = 5.1%) for the modified ash sawdust. Post-treatment, the sawdust can undergo a thermal conversion for energy production. The preliminary findings of this scoping work indicate the feasibility of converting sawdust waste into a novel means for wastewater treatment systems capable of dealing with antibiotic pollutants. The simplicity of the method offers many developing and developed economies, a sustainable means of managing this dangerous emerging problem.

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The Case against Antibiotics and for Anti-Virulence Therapeutics

2021

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Although antibiotics have been indispensable in the advancement of modern medicine, there are downsides to their use. Growing resistance to broad-spectrum antibiotics is leading to an epidemic of infections untreatable by first-line therapies. Resistance is exacerbated by antibiotics used as growth factors in livestock, over-prescribing by doctors, and poor treatment adherence by patients. This generates populations of resistant bacteria that can then spread resistance genes horizontally to other bacterial species, including commensals. Furthermore, even when antibiotics are used appropriately, they harm commensal bacteria leading to increased secondary infection risk. Effective antibiotic treatment can induce bacterial survival tactics, such as toxin release and increasing resistance gene transfer. These problems highlight the need for new approaches to treating bacterial infection. Current solutions include combination therapies, narrow-spectrum therapeutics, and antibiotic stewardship programs. These mediate the issues but do not address their root cause. One emerging solution to these problems is anti-virulence treatment: preventing bacterial pathogenesis instead of using bactericidal agents. In this review, we discuss select examples of potential anti-virulence targets and strategies that could be developed into bacterial infection treatments: the bacterial type III secretion system, quorum sensing, and liposomes.

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Occurrence and Removal of Antibiotics, Antibiotic-Resistance Genes and Bacterial Communities in Hospital Wastewater

Cited by 3 publications

References 61 publications

The Formation of Antibiotic Resistance Genes in Bacterial Communities During Garlic Powder Processing

The Formation of Antibiotic Resistance Genes in Bacterial Communities During Garlic Powder Processing

A Sustainable Method to Reduce Vancomycin Concentrations in Water Using Timber Waste

The Case against Antibiotics and for Anti-Virulence Therapeutics

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