Occurrence and Predictors of Dexmedetomidine Infusion Intolerance and Failure

Tellor, Bethany; Arnold, Heather; Micek, Scott T.; Kollef, Marin H.

doi:10.3810/hp.2012.02.959

Cited by 20 publications

(18 citation statements)

References 15 publications

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“…Patients sedated with dexmedetomidine had statistically lower hypoxia rates in the present study. Furthermore, patients administered dexmedetomidine have been previously shown to be easily awaken during endoscopy and experience less respiratory depression compared with those sedated with midazolam (33,34). Therefore, dexmedetomidine may be advantageous compared with midazolam for the sedation of patients with previous history of respiratory diseases.…”

Section: Discussionmentioning

confidence: 98%

Dexmedetomidine versus midazolam for sedation during endoscopy: A meta-analysis

Zhang

Sun

Zheng

et al. 2016

Experimental and Therapeutic Medicine

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Patients undergoing endoscopy frequently require sedation, which commonly includes the administration of midazolam or dexmedetomidine. Previous meta-analyses have mainly focused on comparing the effects of these two drugs in intensive care unit patients. In the present study, randomized controlled trials (RCTs) that compared the sedative and clinical effectiveness of these two drugs in patients undergoing endoscopy were searched in a number of databases. The meta-analysis showed that dexmedetomidine demonstrated a significantly lower rate of respiratory depression and adverse events compared with those presented upon midazolam administration. A significant difference was also observed in the sedation potency of the sedatives. The current controlled data suggest that dexmedetomidine may be an alternative to midazolam in the sedation for endoscopy. However, more high-quality and well-designed studies are required to further evaluate this conclusion.

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Section: Discussionmentioning

confidence: 98%

Dexmedetomidine versus midazolam for sedation during endoscopy: A meta-analysis

Zhang

Sun

Zheng

et al. 2016

Experimental and Therapeutic Medicine

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“…Since dexmedetomidine binds to a2 receptors rather than gamma-aminobutyric acid (GABA) receptors, patients can be easily aroused from sedation and experience less significant respiratory depression than those sedated using midazolam. 31,32 Endotracheal intubation should be considered in patients with poor respiratory status (SpO 2 < 85%) or those who are deeply unconscious (RSS score !6).…”

Section: Discussionmentioning

confidence: 99%

Dexmedetomidine versus midazolam for sedation in upper gastrointestinal endoscopy

Chen

Zhang

et al. 2014

J Int Med Res

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Objectives: To investigate the efficacy and safety of sedation with dexmedetomidine in upper gastrointestinal endoscopy. Methods: Patients with ASA physical status I-II undergoing elective upper gastrointestinal endoscopy were randomly allocated to receive dexmedetomidine or midazolam for conscious sedation. Continuous peripheral oxygen saturation (SpO 2 ), heart rate, mean arterial pressure (MAP), Ramsay Sedation Scale (RSS) and numeric rating scale pain scores were recorded before, during and after the procedure. Patients completed a post-procedure satisfaction questionnaire. Results: Patients in the midazolam group (n ¼ 30) experienced a significant decrease in MAP during sedation compared with pre-sedation values. Patients in the dexmedetomidine group (n ¼ 30) had significantly higher SpO 2 and RSS scores during sedation than those in the midazolam group. Overall satisfaction was higher in the dexmedetomidine group than the midazolam group. There were no clinically significant complications in either group. Conclusion: Dexmedetomidine has a good safety profile and is an effective sedative for use in upper gastrointestinal endoscopy.

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“…However, group A used a loading dose of 1.0 mg/kg of Although DEX has been used for several decades for sedation, its role in clinical practice has revealed broad variability in clinical response [9][10][11]; the sedation protocols and regimens varied among the studies. In the therapeutic dose range, DEX is not associated with respiratory depression despite deep sedation [12,13].…”

Section: Discussionmentioning

confidence: 99%