Occurrence and measurement of nifedipine and its nitropyridine derivative in human blood plasma

Dokládalová, J.; Tykal, J.A.; Coco, S.J.; Durkee, P.E.; Quercia, G.T.; Korst, J.J.

doi:10.1016/s0378-4347(00)81871-x

Cited by 65 publications

(9 citation statements)

References 3 publications

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“…The retention times for NIF, DNIF and IS were 1.93, 1.84 and 1.95 min, respectively. The method had a significantly shorter total running time (2.5 min) for simultaneous determination of NIF and DNIF compared with those reported in the literature [19,28,30,35,38,39].…”

Section: Selectivitymentioning

confidence: 73%

“…Most of these reported analytical methods involve the application of gas chromatography (GC) and liquid chromatography (LC). The reported GC methods often utilize electron-capture detection [18,[26][27][28][29][30], flame ionization detection [31], nitrogen-phosphorus detection [32], or mass spectrometric (MS) detection [33,34]. Although the sensitivity of GC/MS is high in pharmacokinetic and pharmacogenetic studies, the GC method has several concerning drawbacks, such as thermal degradation of NIF and DNIF due to high temperatures during analysis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography–tandem mass spectrometry: Application to a clinical herb–drug interaction study

Wang

et al. 2007

Journal of Chromatography B

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Section: Selectivitymentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography–tandem mass spectrometry: Application to a clinical herb–drug interaction study

Wang

et al. 2007

Journal of Chromatography B

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“…NF is metabolized to three known metabolites. Besides its pyridine derivative (M I) [ 10], the acids M II and M III are produced [11] (fig. 8).…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetics and Metabolism of Calcium-Blocking Agents Nifedipine, Nitrendipine, and Nimodipine

et al. 1986

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“…At the same time, blood samples were collected for standard biochemical analysis and serum cholesterol and triglyceride levels. The nifedipine serum levels were determined by gas chromatography 23 in blood samples taken 1 hour before drug administration.…”

Section: Methodsmentioning

confidence: 99%

A nifedipine-sensitive smooth muscle cell population is present in the atherosclerotic rabbit aorta.

Pauletto

Scannapieco

Borrione

et al. 1991

Arterioscler Thromb

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We evaluated the ability of the Ca 2+ channel blocker nifedipine to influence the severity of atherosclerotic lesions and the pattern of aortic smooth muscle cell (SMC) differentiation in cholesterol-fed New Zealand White rabbits. The animals were fed a 1% cholesterol-enriched diet for 12 weeks. After 4 weeks of the diet, some rabbits were given nifedipine (20 mg b.i.d.) for another 8 weeks without discontinuation of the cholesterol-enriched diet (experiment 1). Another group of rabbits was treated with nifedipine from the beginning of the cholesterolenriched diet for the entire 12 weeks (experiment 2). The severity of atherosclerotic lesions was determined by computerized planimetry, and qualitative effects of nifedipine on SMCs were studied by monoclonal antibodies specific for smooth muscle and nonmuscle myosins. In the aortic media of normal rabbits, these antibodies can identify an SMC population with an "immature" type of myosin pattern; a marked increase in the number of these cells is observed during atherogenesis. In experiment 1, we observed a marked decrease of medial SMCs with the immature type of myosin pattern, without any significant reduction in atherosclerosis severity. In experiment 2, disappearance of the previously mentioned medial SMC population was accompanied by a dramatic slowing of intimal lesion development. These results indicate that nifedipine treatment is effective in reducing atherosclerotic lesions only when given from the beginning of a cholesterol-enriched diet. Delay of nifedipine administration until the fourth week of the cholesterol-enriched diet fails to halt progression of the disease. The observed antiatherosclerotic activity can be attributable to a direct effect of the drug on the medial SMC population, which increases during the course of experimental atherogenesis. (Arteriosclerosis and Thrombosis 1991;ll:928-939)

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Occurrence and measurement of nifedipine and its nitropyridine derivative in human blood plasma

Cited by 65 publications

References 3 publications

Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography–tandem mass spectrometry: Application to a clinical herb–drug interaction study

Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography–tandem mass spectrometry: Application to a clinical herb–drug interaction study

Pharmacokinetics and Metabolism of Calcium-Blocking Agents Nifedipine, Nitrendipine, and Nimodipine

A nifedipine-sensitive smooth muscle cell population is present in the atherosclerotic rabbit aorta.

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