Occurrence and health risk assessment of aflatoxins and ochratoxin a in Sürk, a Turkish dairy food, as studied by HPLC

Sakin, Fatih; Tekeli, İbrahim Ozan; Yi̇pel, Mustafa; Kürekçi, Cemil

doi:10.1016/j.foodcont.2018.03.012

Cited by 41 publications

(19 citation statements)

References 41 publications

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“…To the best of our knowledge, not a single study is published on the estimation of MOE values through consumption of aflatoxin contaminated black tea. In a study conducted by Sakin et al (2018), the EDI of aflatoxins through Surk (a Turkish dairy food) was estimated to be 0.057 and the mean MOE values for AFB 1 was reported as 2982. Andrade et al (2013) reported the MOE values for Brazilian population based on 942 food items, the MOE values ranged between 6 and 25.…”

Section: Exposure Assessment and Health Risk Characterization Of Aflamentioning

confidence: 99%

Prevalence and Exposure Assessment of Aflatoxins Through Black Tea Consumption in the Multan City of Pakistan and the Impact of Tea Making Process on Aflatoxins

et al. 2020

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Aflatoxins are the highly toxic secondary metabolites of certain fungi, being mainly produced by Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are classified as group 1 category carcinogens by the International Agency for Research on Cancer (IARC). A large number of food commodities are reported to be contaminated with aflatoxins. Tea is the world's second most consumed beverage and the consumption of tea is increasing day by day. Besides being a source of several health promoting substances, tea leaves are also reported to be contaminated with aflatoxins. However, not a single study is reported from Pakistan regarding the level of aflatoxins in commercially available black tea samples. The current study aimed to quantify the level of aflatoxins in commercially available branded and non-branded black tea samples. The estimated daily intake (EDI) of aflatoxins through branded and non-branded black tea consumption and the health risk assessment based on margin of exposure (MOE) approach was assessed. Furthermore, the impact of local tea making processes on the concentration of aflatoxins in tea beverage (filtrate) was also investigated.

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Section: Exposure Assessment and Health Risk Characterization Of Aflamentioning

confidence: 99%

Prevalence and Exposure Assessment of Aflatoxins Through Black Tea Consumption in the Multan City of Pakistan and the Impact of Tea Making Process on Aflatoxins

et al. 2020

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“…The LOD of the AFM1 achieved by voltammetry is sufficient for determination of the toxin on the level of its permissible concentrations in food products [54,55,56], and is comparable to characteristics of other electrochemical aptasensors reported. Thus, the use of intrinsic redox activity of polyaniline bearing covalently attached aptamer exerted LOD of 2 ng/L [35] and that with the thiolated aptamer directly attached to Au electrode 1 ng/mL (EIS measurements [58] DNA sensors with Neutral red covalently attached together with the aptamer to the polymeric support offered detection of 10 ng/L AFM1 in EIS mode [59].…”

Section: Resultsmentioning

confidence: 60%

“…In the United States, the FDA requirements 0.50 µg/kg AFM1 in milk [54]. To date, AFM1 has been determined by various HPLC techniques [55,56] and immunoassay [57]. Being sensitive, such methods are time and labor consuming, and cannot be used under field conditions.…”

Section: Resultsmentioning

confidence: 99%

DNA-Polylactide Modified Biosensor for Electrochemical Determination of the DNA-Drugs and Aptamer-Aflatoxin M1 Interactions

Stepanova

Smolko

Gorbatchuk

et al. 2019

Sensors

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DNA sensors were assembled by consecutive deposition of thiacalix[4]arenes bearing oligolactic fragments, poly(ethylene imine), and DNA onto the glassy carbon electrode. The assembling of the layers was monitored with scanning electron microscopy, cyclic voltammetry and electrochemical impedance spectroscopy. The configuration of the thiacalix[4]arene core determined self-assembling of the polymeric species to the nano/micro particles with a size of 70–350 nm. Depending on the granulation, the coatings show the accumulation of a variety of DNA quantities, charges, and internal pore volumes. These parameters were used to optimize the DNA sensors based on these coatings. Thus, doxorubicin was determined to have limits of detection of 0.01 nM (cone configuration), 0.05 nM (partial cone configuration), and 0.10 nM (1,3-alternate configuration of the macrocycle core). Substitution of native DNA with aptamer specific to aflatoxin M1 resulted in the detection of the toxin in the range of 20 to 200 ng/L (limit of detection 5 ng/L). The aptasensor was tested in spiked milk samples and showed a recovery of 80 and 85% for 20 and 50 ng/L of the aflatoxin M1, respectively.

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“…Nevertheless, if the targeted toxins have different physico-chemical properties, it improves the difficulties to find the extraction conditions leading to high recoveries for all the toxins [ 42 ] without affecting the stability of some of them [ 48 ]. This may explain why some authors preferred to run the samples over several ISs [ 51 ] even if it means assembling the ISs in series for the elution step [ 61 ].…”

Section: Immunoaffinity Sorbentsmentioning

confidence: 99%

Immunoaffinity Extraction and Alternative Approaches for the Analysis of Toxins in Environmental, Food or Biological Matrices

Delaunay

Combès

Pichon

2020

Toxins

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The evolution of instrumentation in terms of separation and detection allowed a real improvement of the sensitivity and analysis time. However, the analysis of ultra-traces of toxins in complex samples requires often a step of purification and even preconcentration before their chromatographic analysis. Therefore, immunoaffinity sorbents based on specific antibodies thus providing a molecular recognition mechanism appear as powerful tools for the selective extraction of a target molecule and its structural analogs to obtain more reliable and sensitive quantitative analysis in environmental, food or biological matrices. This review focuses on immunosorbents that have proven their efficiency in selectively extracting various types of toxins of various sizes (from small mycotoxins to large proteins) and physicochemical properties. Immunosorbents are now commercially available, and their use has been validated for numerous applications. The wide variety of samples to be analyzed, as well as extraction conditions and their impact on extraction yields, is discussed. In addition, their potential for purification and thus suppression of matrix effects, responsible for quantification problems especially in mass spectrometry, is presented. Due to their similar properties, molecularly imprinted polymers and aptamer-based sorbents that appear to be an interesting alternative to antibodies are also briefly addressed by comparing their potential with that of immunosorbents.

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Occurrence and health risk assessment of aflatoxins and ochratoxin a in Sürk, a Turkish dairy food, as studied by HPLC

Cited by 41 publications

References 41 publications

Prevalence and Exposure Assessment of Aflatoxins Through Black Tea Consumption in the Multan City of Pakistan and the Impact of Tea Making Process on Aflatoxins

Prevalence and Exposure Assessment of Aflatoxins Through Black Tea Consumption in the Multan City of Pakistan and the Impact of Tea Making Process on Aflatoxins

DNA-Polylactide Modified Biosensor for Electrochemical Determination of the DNA-Drugs and Aptamer-Aflatoxin M1 Interactions

Immunoaffinity Extraction and Alternative Approaches for the Analysis of Toxins in Environmental, Food or Biological Matrices

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