Occurrence and fate of amisulpride, sulpiride, and lamotrigine in municipal wastewater treatment plants with biological treatment and ozonation

Bollmann, Anna; Seitz, Wolfram; Prasse, Carsten; Lücke, Thomas; Schulz, W.; Ternes, Thomas A.

doi:10.1016/j.jhazmat.2016.08.022

Cited by 101 publications

(41 citation statements)

References 42 publications

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“…Nevertheless, these methods might not be adequate to remove the large variety of organic compounds present in wastewater. Thus, the effluents of conventional treatment plants are major sources of chemical discharges into the aquatic system [12].…”

Section: Introductionmentioning

confidence: 99%

Light-Induced Reactions of Chlorpromazine in the Presence of a Heterogeneous Photocatalyst: Formation of a Long-Lasting Sulfoxide

et al. 2019

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A commercial carbon-modified titanium dioxide, KRONOClean 7000, was applied as a UV(A) and visible-light active photocatalyst to investigate the conversion of the antipsychotic pharmaceutical chlorpromazine in aqueous phase employing two monochromatic light sources emitting at wavelengths of 365 and 455 nm. Photocatalytic and photolytic conversion of chlorpromazine under both anaerobic and aerobic conditions was analyzed using a HPLC-MS technique. Depending on the irradiation wavelength and presence of oxygen, varying conversion rates and intermediates revealing different reaction pathways were observed. Upon visible light irradiation under aerobic conditions, chlorpromazine was only converted in the presence of the photocatalyst. No photocatalytic conversion of this compound under anaerobic conditions upon visible light irradiation was observed. Upon UV(A) irradiation, chlorpromazine was successfully converted into its metabolites in both presence and absence of the photocatalyst. Most importantly, chlorpromazine sulfoxide, a very persistent metabolite of chlorpromazine, was produced throughout the photolytic and photocatalytic conversions of chlorpromazine under aerobic conditions. Chlorpromazine sulfoxide was found to be highly stable under visible light irradiation even in the presence of the photocatalyst. Heterogeneous photocatalysis under UV(A) irradiation resulted in a slow decrease of the sulfoxide concentration, however, the required irradiation time for its complete removal was found to be much longer compared to the removal of chlorpromazine at the same initial concentration.

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Section: Introductionmentioning

confidence: 99%

Light-Induced Reactions of Chlorpromazine in the Presence of a Heterogeneous Photocatalyst: Formation of a Long-Lasting Sulfoxide

et al. 2019

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“…In contrast, anxiolytics and anaesthetics were not observed in high concentrations, although some of their representative compounds, such as tramadol and lidocaine, were detected in many of the samples. The latter two PhACs were also found to be highly persistent, as reported by Bollmann et al (2016), Wood et al (2017), Malchi et al (2014) and López-García et al (2018). It should be noted that neither the occurrence or concentration of PhACs was found to be related to the chemical properties of the spa water (Table S1).…”

Section: General Resultsmentioning

confidence: 69%

“…Tourist influx in the summer causes the number of visitors to increase, and can also profoundly impact contamination levels. Based on statistics the types of winter and summer visitors significantly differ (Csapó and Marton 2017). Tourists from abroad are overrepresented in summer visitors, whereas the ratio of elderly locals is higher during the winter (HCSO 2017).…”

Section: Introductionmentioning

confidence: 99%

Thermal baths as sources of pharmaceutical and illicit drug contamination

Jakab

Szalai

Michalkó

et al. 2019

Environ Sci Pollut Res

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Despite the fact that there are tens of thousands of thermal baths in existence, knowledge about the occurrence of pharmaceutically active compounds (PhACs) in untreated thermal wastewater is very limited. Because used thermal water is typically legally discharged into surface waters without any treatment, the effluent poses environmental risks for the receiving water bodies. The aim of this study was to show the occurrence patterns and spatiotemporal characteristics of 111 PhACs in thermal wastewater. Six thermal water outflows of different thermal baths were tested in different seasons in the Budapest metropolitan region (Hungary), and diurnal analysis was performed. After solid-phase extraction, the samples were analysed and quantified by coupling supercritical fluid chromatography and mass spectrometry to perform simultaneous multi-residue drug analysis. The results confirm that water discharge pipes directly transport pharmaceuticals into surface water bodies; 34 PhACs were measured to be over the limit of quantification at least once, and 21 of them were found in more than one water sample. The local anaesthetic drug lidocaine, antiepileptic carbamazepine, analgesic derivative tramadol and illicit drug cocaine were detected in more than half of the samples. Caffeine, metoprolol and bisoprolol (cardiovascular drugs), benzoylecgonine (cocaine metabolite), diclofenac (NSAID), citalopram (antidepressant) and certain types of hormones also have a significant frequency of 30-50%. However, the occurrence and concentrations of PhACs vary according to the season and number/types of visitors. As demonstrated by the diurnal fluctuation, drug contamination of thermal waters can significantly vary, even for similar types of baths; furthermore, the quantity and types of some pollutants rapidly change in the discharged thermal wastewater.

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“…For instance, Bollmann et al (2016) [40] performed removal of amisulpride, sulpiride and lamotrigine in municipal wastewater treatment plants using ozone treatment. The ozonation of all three pharmaceutical drugs was evidenced to form N-oxidation products which failed to be degraded by the biodegradation experiments using activated sludge.…”

Section: Conventional Wastewater Treatment Methodsmentioning

confidence: 99%

Removal of Pharmaceutical Contaminants in Wastewater Using Nanomaterials: A Comprehensive Review

Chauhan

Sillu

Agnihotri

2019

CDM

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Background: The limitless presence of pharmaceutical contaminants in discharged wastewater has emerged as a threat to aquatic species and humans. Their presence in drinking water has although raised substantial concerns, very little is known about the fate and ecological impacts of these pollutants. As a result, these pollutants are inevitably introduced to our food chain at trace concentrations. Unfortunately, the conventional wastewater treatment techniques are unable to treat pharmaceuticals completely with practical limitations. The focus has now been shifted towards nanotechnology for the successful remediation of these persistent pollutants. Thus, the current review specifically focuses on providing readers brief yet sharp insights into applications of various nanomaterials for the removal of pharmaceutical contaminants. Methods: An exhaustive collection of bibliographic database was done with articles having high impact and citations in relevant research domains. An in-depth analysis of screened papers was done through standard tools. Studies were categorized according to the use of nanoscale materials as nano-adsorbents (graphene, carbon nanotubes), nanophotocatalysts (metal, metal oxide), nano-filtration, and ozonation for promising alternative technologies for the efficient removal of recalcitrant contaminants. Results: A total of 365 research articles were selected. The contemporary advancements in the field of nanomaterials for drinking and wastewater treatment have been thoroughly analyzed along with their future perspectives. Conclusion: The recommendations provided in this article will be useful to adopt novel strategies for on-site removal of the emerging contaminants in pharmaceutical effluents and related industries.

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Occurrence and fate of amisulpride, sulpiride, and lamotrigine in municipal wastewater treatment plants with biological treatment and ozonation

Cited by 101 publications

References 42 publications

Light-Induced Reactions of Chlorpromazine in the Presence of a Heterogeneous Photocatalyst: Formation of a Long-Lasting Sulfoxide

Light-Induced Reactions of Chlorpromazine in the Presence of a Heterogeneous Photocatalyst: Formation of a Long-Lasting Sulfoxide

Thermal baths as sources of pharmaceutical and illicit drug contamination

Removal of Pharmaceutical Contaminants in Wastewater Using Nanomaterials: A Comprehensive Review

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