Occurrence and ecotoxicological risk assessment of non-steroidal anti-inflammatory drugs in South African aquatic environment: What is known and the missing information?

Madikizela, Lawrence Mzukisi; Ncube, Somandla

doi:10.1016/j.chemosphere.2021.130688

Cited by 37 publications

(24 citation statements)

References 67 publications

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“…Monitoring and health risk assessment studies are still a new niche in South Africa with most studies targeting mainly nonsteroidal anti-inflammatory drugs (Madikizela et al, 2020;Madikizela and Ncube, 2021). This also has implications for creation of databases of priority lists and compounds relevant to Africa.…”

Section: Introductionmentioning

confidence: 99%

Trace Detection and Quantitation of Antibiotics in a South African Stream Receiving Wastewater Effluents and Municipal Dumpsite Leachates

Ncube

Nuapia

Chimuka

et al. 2021

Front. Environ. Sci.

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One of the major concerns in the consumption of antibiotics is the discovery of antibacterial resistant genes due to prolonged exposure which makes their presence in environmental samples a priority. In this study, we screened 52 antibiotics along a South African stream polluted with wastewater effluents and municipal dumpsite leachates. Of these antibiotics, 15 were detected in the stream while 3 sulfonamides (sulfamethizole, sulfamethazine, sulfamethoxazole), a fluoroquinolone (flumequine) and a diaminopyrimidine (trimethoprim) were further quantified. The concentrations of sulfamethizole, sulfamethazine, sulfamethoxazole ranged from not detected to 0.133 µg L−1, flumequine ranged from 0.222 to 0.686 µg L−1, while trimethoprim was up to 0.0618 µg L−1. The highest concentrations were recorded at the point source discharge with most antibiotics not detected further downstream. The current study has further confirmed wastewater effluents and dumpsite leachates as pathways of antibiotics into the environment. Only the persistent unsanctioned antibiotic, flumequine had its risk quotient above 0.1 making it an antibiotic of environmental concern. Multiresidue studies are still limited in Africa and the current study offers a platform for a research paradigm shift with more studies expected to emerge providing an improved overview of the release of antibiotics and other pharmaceuticals into Africa’s vulnerable surface water systems.

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Section: Introductionmentioning

confidence: 99%

Trace Detection and Quantitation of Antibiotics in a South African Stream Receiving Wastewater Effluents and Municipal Dumpsite Leachates

Ncube

Nuapia

Chimuka

et al. 2021

Front. Environ. Sci.

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“…2c), during the 3 rd spiking, caused by Spirogyra sp., a filamentous Zygnemaphyceae. The same occurred on the 2 nd and 3 rd spikings for ibuprofen, indicating that this pharmaceutical may have been toxic to other species and favoured the predominance of Spirogyra sp.. Madikizela and Ncube (2021), who evaluated the occurrence and ecotoxicological risk assessment of non-steroidal antiinflammatory drugs in South African, describe that the ibuprofen seems to be the one with the high ecotoxicological risks than other non-steroidal anti-inflammatory drugs (NSAIDs) for algae. It was observed that the Bacillariophyta group had a reduced contribution to the community throughout the addition of PPCPs, indicating a possible sensitivity to the presence of the PPCPs.…”

Section: Quantitative Analyses Of Phytoplanktonmentioning

confidence: 87%

The impact of micropollutants on native algae and cyanobacteria communities in ecological filters during drinking water treatment

Pompei

Campos

Vieira

et al. 2022

Science of The Total Environment

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“…Accumulation of NSAIDs in the environment endangers non-target organisms and human health ( Oaks et al, 2004 ; Gamarra et al, 2015 ; Schmidt and Redshaw, 2015 ; Mezzelani et al, 2016 ; Horie et al, 2019 ; Izadi et al, 2020 ; Parolini, 2020 ; Madikizela and Ncube, 2021 ; Moreno-Opo et al, 2021 ).…”

Section: Biodegradation Of Pharmaceutical Pollutantsmentioning

confidence: 99%

Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future

2022

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Active pharmaceutical ingredients present a substantial risk when they reach the environment and drinking water sources. As a new type of dangerous pollutants with high chemical resistance and pronounced biological effects, they accumulate everywhere, often in significant concentrations (μg/L) in ecological environments, food chains, organs of farm animals and humans, and cause an intense response from the aquatic and soil microbiota. Rhodococcus spp. (Actinomycetia class), which occupy a dominant position in polluted ecosystems, stand out among other microorganisms with the greatest variety of degradable pollutants and participate in natural attenuation, are considered as active agents with high transforming and degrading impacts on pharmaceutical compounds. Many representatives of rhodococci are promising as unique sources of specific transforming enzymes, quorum quenching tools, natural products and novel antimicrobials, biosurfactants and nanostructures. The review presents the latest knowledge and current trends regarding the use of Rhodococcus spp. in the processes of pharmaceutical pollutants’ biodegradation, as well as in the fields of biocatalysis and biotechnology for the production of targeted pharmaceutical products. The current literature sources presented in the review can be helpful in future research programs aimed at promoting Rhodococcus spp. as potential biodegraders and biotransformers to control pharmaceutical pollution in the environment.

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Occurrence and ecotoxicological risk assessment of non-steroidal anti-inflammatory drugs in South African aquatic environment: What is known and the missing information?

Cited by 37 publications

References 67 publications

Trace Detection and Quantitation of Antibiotics in a South African Stream Receiving Wastewater Effluents and Municipal Dumpsite Leachates

Trace Detection and Quantitation of Antibiotics in a South African Stream Receiving Wastewater Effluents and Municipal Dumpsite Leachates

The impact of micropollutants on native algae and cyanobacteria communities in ecological filters during drinking water treatment

Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future

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