Occurrence and developmental consequences of vacuoles throughout preimplantation development

Ebner, Thomas; Moser, Marianne; Sommergruber, Michael; Gaiswinkler, U; Shebl, Omar; Jesacher, Klaus; Tews, G

doi:10.1016/j.fertnstert.2005.02.009

Cited by 103 publications

(71 citation statements)

References 19 publications

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“…It has been proposed that oocyte vacuoles arise either spontaneously or by fusion of vesicles derived from the smooth endoplasmic reticulum and/or Golgi apparatus [20]. How vacuolisation affects fertilisation and pronuclear formation is still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…During the completion of meiosis I and the transition to the metaphase II stage, synchronous cytoplasmic maturation, mitochondrial changes, protein synthesis and cytoskeletal changes take place [38]. It has been suggested that the presence of intracytoplasmic vacuoles is associated with severe oocyte degeneration, displacement of the MII spindle from its polar position [45], abnormal cytokinesis pattern [32,45], compromised embryo development [3] and impaired blastocyst formation [20].…”

Section: Discussionmentioning

confidence: 99%

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The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

Setti

Braga

Figueira

et al. 2012

J Assist Reprod Genet

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Purpose To evaluate the relationship between oocyte dysmorphisms and IMSI outcomes Methods Data of IMSI cycles performed in 332 patients were included in this study. Patients were included only if presented more than four and less than 30 oocytes upon oocyte retrieval. Patients who underwent IMSI were matched, concerning female age and sperm parameters, with patients who underwent ICSI in the same period (n0332). The two groups (ICSI and IMSI) were compared with regard to treatment outcomes. The influence of IMSI on fertilization and embryo quality on D3 and D5, when oocyte dysmorphisms were present was analyzed. Results A total of 6444 oocytes were morphologically evaluated and injected. Regardless of the oocyte quality, IMSI performance was a determinant of the increased odds of development to high quality embryo on D3 (OR: 1.98; CI: 1.54-2.56) and D5 (OR: 3.27; CI: 1.61-6.66). Conclusions The selection of a morphologically normal spermatozoon under high-magnification is associated with increased embryo quality, regardless of the oocyte morphology. The injection of a spermatozoon, selected under highmagnification, into a morphologically normal oocyte leads to the highest probability of developing high quality embryos.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

Setti

Braga

Figueira

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…However, increasing vacuole diameter negatively influences the fertilization rate because vacuoles interfere with cytoskeleton functioning and formation of the meiotic spindle (Ebner et al, 2005;Van Blerkom, 1990). …”

Section: Cytoplasmmentioning

confidence: 99%

Morphology and Aneuploidy of in vitro Matured (IVM) Human Oocytes

Bombek¹,

Kovačič²,

Vlaisavljević³

2012

Aneuploidy in Health and Disease

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“…Dysmorphic oocytes, i.e., those exhibiting centrally located granular cytoplasm (CLGC) [7], vacuolization [8], or smooth endoplasmic reticulum clusters (sERC) [9,10], are frequently observed [11]. During piezo-ICSI, low-stretching oocytes, which penetrate before piezo pulse application, are also common [12].…”

Section: Introductionmentioning

confidence: 99%

“…During piezo-ICSI, low-stretching oocytes, which penetrate before piezo pulse application, are also common [12]. Previous studies [7][8][9][10][11][12] report low pregnancy rates using fertilized eggs derived from oocytes of abnormal morphology or low quality.…”

Section: Introductionmentioning

confidence: 99%

Oocyte quality improvement using a herbal medicine comprising 7 crude drugs

Inoue¹,

Ono²,

Yonezawa³

et al. 2013

OJOG

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Maternal age is a significant factor in infertility treatment. Ovarian function and oocyte quality decrease with age, whereas the frequency of chromosomal abnormalities increases. In this study, improvement of oocyte quality and ovarian function were attempted using a herbal medicine comprising 7 crude drugs: Angelicae radix, Rehmanniae radix, Plantaginis semen, Lonicerae flos, Carthami flos, Ginseng radix, and Cucurbita moschata Duch. Thirty-one women who repeatedly failed to conceive by intracytoplasmic sperm injection took the herbal medicine before breakfast and dinner from the start of menstrual cycle in the ovum pickup cycle. Average patient age was 38.5 ± 0.7 years, and the average ovum pickup frequency on the first dosage day was 7.9 ± 1.5. To analyze the effects of herbal medicine intake, the number of recovered and mature oocytes, their morphology and physical qualities, as well as the rates of fertilization, oocyte development, and pregnancy was compared before and after intake. The recovered and mature oocyte numbers, oocyte morphology and physical qualities, and fertilization rate were not significantly different before and after drug intake. However, the oocyte development rate was significantly higher (58.0%) after herbal medicine intake than before (32.5%; p = 0.0003). Moreover, the successful pregnancy rate was significantly higher after intake than before (6.9% versus 0%; p = 0.0111). Herbal medicine may constitute a useful adjunct to assisted reproductive technology in women.

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Occurrence and developmental consequences of vacuoles throughout preimplantation development

Cited by 103 publications

References 19 publications

The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

Morphology and Aneuploidy of in vitro Matured (IVM) Human Oocytes

Oocyte quality improvement using a herbal medicine comprising 7 crude drugs

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